Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Dana L. T. Laird"'
Autor:
Eugene F. Kogut, Neil J. Kallman, Dana L. T. Laird, Marvin M. Hansen, J. Craig Ruble, Chin Liu, Lawrence Edward Patterson, Matthew H. Yates, Ryan J. Linder
Publikováno v:
Organic Process Research & Development. 18:501-510
The synthesis of a MET kinase inhibitor in an overall yield of 22% was achieved over eight steps starting with 3-hydroxybenzaldehyde, an improvement from the initial 12-step process with a 5.4% yield. Highlights of the process chemistry design and de
Autor:
Gregory A. Stephenson, Bret A. Astleford, Dana L. T. Laird, John R. Rizzo, Adam D. McFarland, Todd D. Maloney, Nicholas A. Magnus, J. Craig Ruble, James P. Wepsiec
Publikováno v:
The Journal of Organic Chemistry. 78:5768-5774
Serotonin norepinephrine reuptake inhibitor (SNRI) pyrrolidinyl ether 2 was synthesized by employing a dynamic kinetic resolution (DKR) with enantio- and diastereoselective hydogenation on β-keto-γ-lactam 8 to afford β-hydroxy-γ-lactam 9 with 96%
Improved Synthesis of C4α- and C4β-Methyl Analogues of 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate
Autor:
J. Craig Ruble, James A. Monn, Dana L. T. Laird, Molly D. Brady, Steven S. Henry, Varie David Lee
Publikováno v:
Organic Letters. 14:2662-2665
An efficient and divergent synthesis of C4α- and C4β-methyl-substituted analogues of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate, which are important tools in the study of metabotropic glutamate receptor function, has been achieved. By taking adv
Publikováno v:
ChemInform. 43
A key feature is the use of catalytic zinc triflate, which significantly improves turnover frequency and suppresses epimerization in the α-position of the products.
Publikováno v:
Organic letters. 14(4)
The asymmetric hydrogenation of tetrasubstituted α,β-unsaturated ketones has been accomplished using an in situ formed rhodium-Josiphos catalyst. The reaction is enhanced by addition of catalytic zinc(II) triflate, which significantly improves turn
Publikováno v:
ChemInform. 38
4-aminoquinolines, classically prepared via SNAr chemistry from an amine and 4-haloquinoline, are important scaffolds in medicinal chemistry. Interest in these compounds prompted us to explore palladium catalysis as an alternative to the existing met