Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Dana L. Shuey"'
Autor:
Madhumita Basu, Kembra L. Howdeshell, Sonja A. Rasmussen, Kristal A. Rychlik, Thomas B. Knudsen, Dana L. Shuey, William Slikker
Publikováno v:
Birth Defects Research.
Autor:
Dana L. Shuey
Publikováno v:
Birth defects research. 112(12)
Autor:
Dana L. Shuey, James H. Kim
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 92:381-383
Since regulatory agencies began implementing the use of standardized developmental toxicology protocols in the mid-1960s, our knowledge base of embryo-fetal development and technologies for experimentation has grown exponentially. These developmental
Autor:
Dana L. Shuey, M. Leonard Mole, David H. Ellis, M. Frank Copeland, R. Woodrow Setzer, John M. Rogers, Tina R. Logsdon, Christopher Lau, Jennifer Merriman, Robert J. Kavlock, Annie M. Cameron
Publikováno v:
Toxicological Sciences. 59:37-48
Biologically based dose-response (BBDR) models represent an emerging approach to improving the current practice of human health-risk assessment. The concept of BBDR modeling is to incorporate mechanistic information about a chemical that is relevant
Autor:
Joseph M. Lary, Susan L. Schantz, Robert J. Kavlock, Dana L. Shuey, Susan Barlow, John A. Moore, Daniel M. Sheehan
Publikováno v:
Teratology. 60:365-375
SUSAN BARLOW,1 ROBERT J. KAVLOCK,2 JOHN A. MOORE,3 SUSAN L. SCHANTZ,4 DANIEL M. SHEEHAN,5 DANA L. SHUEY,6 AND JOSEPH M. LARY7* 1Consultant Toxicologist, Brighton, East Sussex, BN1 6RE United Kingdom 2Reproductive Toxicology Division, U.S. Environment
Publikováno v:
Teratology. 50:379-386
The chemotherapeutic agent 5-fluorouracil (5-FU) is teratogenic in a number of species, yet the mechanism(s) of its developmental toxicity are not fully understood. Administration of 5-FU to the pregnant CD rat on day 14 of gestation results in dose-
Autor:
Kimberly C. Brannen, Suzanne E. Fenton, Deborah K. Hansen, James H. Kim, Wafa Harrouk, Dana L. Shuey
Publikováno v:
Birth defects research. Part B, Developmental and reproductive toxicology. 92(5)
In April 2009, the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute’s (HESI) Developmental and Reproductive Toxicology Technical Committee held a two-day workshop entitled “Developmental Toxicology—New Di
Autor:
Robert M. Zucker, Christopher Lau, John M. Rogers, Kenneth H. Elstein, Neil Chernoff, Dana L. Shuey
Publikováno v:
Teratology. 48:75-87
Murine erythroleukemic cells (MELC) exposed to 2′-deoxy-5-azacytidine (D-AZA) or to the active cyclophosphamide (CP) metabolites phosphoramide mustard (PAM) and 4-hydroxycyclophosphamide (OHCP) exhibit cell-cycle perturbations similar to those seen
Publikováno v:
Birth defects research. Part B, Developmental and reproductive toxicology. 83(1)
BACKGROUND: Endogenous opioids seem to regulate hypothalamic gonadotropin release in both males and females, as evidenced by the effects of opioid agonists and antagonists on LHRH release and reproductive hormone levels. The effects of long-term oral
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 95(2)
Oxymorphone is a potent opioid analgesic. Oral administration of oxymorphone to rats at doses >or= 20 mg/kg and mice at 500 mg/kg produced an increase in micronucleated polychromatic erythrocytes (MPCEs). Oxymorphone does not produce chromosome aberr