Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Dana L, Tudorascu"'
Autor:
Xuemei Zeng, Yijun Chen, Anuradha Sehrawat, Jihui Lee, Tara K. Lafferty, Julia Kofler, Sarah B. Berman, Robert A. Sweet, Dana L. Tudorascu, William E. Klunk, Milos D. Ikonomovic, Anna Pfister, Henrik Zetterberg, Beth E. Snitz, Anne D. Cohen, Victor L. Villemagne, Tharick A. Pascoal, M. llyas Kamboh, Oscar I. Lopez, Kaj Blennow, Thomas K. Karikari
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-22 (2024)
Abstract Alzheimer’s disease (AD), the most common form of dementia, remains challenging to understand and treat despite decades of research and clinical investigation. This might be partly due to a lack of widely available and cost-effective modal
Externí odkaz:
https://doaj.org/article/64c9dbe829a54f7ea0148397b7f5ae86
Autor:
Laura Xicota, Lam-Ha T. Dang, Alice Lee, Sharon Krinsky-McHale, Deborah Pang, Lisa Melilli, Sid O'Bryant, Rachel L. Henson, Charles Laymon, Florence Lai, H. Diana Rosas, Beau Ances, Ira Lott, Christy Hom, Bradley Christian, Sigan Hartley, Shahid Zaman, Elizabeth Head, Mark Mapstone, Zhezhen Jin, Wayne Silverman, Nicole Schupf, Benjamin Handen, Joseph H. Lee, Howard J. Aizenstein, Beau M. Ances, Howard F. Andrews, Karen Bell, Rasmus Birn, Adam M. Brickman, Peter Bulova, Amrita Cheema, Kewei Chen, Bradley T. Christian, Isabel Clare, Lorraine Clark, Ann D. Cohen, John N. Constantino, Eric W. Doran, Anne Fagan, Eleanor Feingold, Tatiana M. Foroud, Benjamin L. Handen, Jordan Harp, Sigan L. Hartley, Rachel Henson, Lawrence Honig, Milos D. Ikonomovic, Sterling C. Johnson, Courtney Jordan, M.Ilyas Kamboh, David Keator, William E. Klunk, Julia K. Kofler, William Charles Kreisl, Sharon J. Krinsky-McHale, Patrick Lao, Ira T. Lott, Victoria Lupson, Chester A. Mathis, Davneet Singh Minhas, Neelesh Nadkarni, Sid O’Bryant, Melisa Parisi, Melissa Pettersen, Julie C. Price, Margaret Pulsifer, Michael S. Rafii, Eric Reiman, Batool Rizvi, Laurie Ryan, Frederick Schmitt, Wayne P. Silverman, Dana L. Tudorascu, Rameshwari Tumuluru, Benjamin Tycko, Badri Varadarajan, Desiree A. White, Michael A. Yassa, Fan Zhang
Publikováno v:
EBioMedicine, Vol 110, Iss , Pp 105433- (2024)
Summary: Background: Individuals with Down syndrome (DS) are at high risk of early-onset Alzheimer's disease (AD); yet, some 20 percent do not develop any signs of dementia until after 65 years or in their lifetime. Mosaicism could contribute to this
Externí odkaz:
https://doaj.org/article/7bcbc45f9a5e40b7ab0502504ef1c084
Autor:
Emily K. Schworer, Benjamin L. Handen, Melissa Petersen, Sid O'Bryant, Jamie C. Peven, Dana L. Tudorascu, Laisze Lee, Sharon J. Krinsky‐McHale, Christy L. Hom, Isabel C. H. Clare, Bradley T. Christian, Nicole Schupf, Joseph H. Lee, Elizabeth Head, Mark Mapstone, Ira Lott, Beau M. Ances, Shahid Zaman, Adam M. Brickman, Florence Lai, H. Diana Rosas, Sigan L. Hartley, the Alzheimer Biomarker Consortium‐Down Syndrome
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION People with Down syndrome (DS) have a 75% to 90% lifetime risk of Alzheimer's disease (AD). AD pathology begins a decade or more prior to onset of clinical AD dementia in people with DS. It is not clear if plasma biomarkers of A
Externí odkaz:
https://doaj.org/article/13dbf3a21419485bb2909612d2c5af23
Autor:
Maxwell Reynolds, Tigmanshu Chaudhary, Mahbaneh Eshaghzadeh Torbati, Dana L. Tudorascu, Kayhan Batmanghelich
Publikováno v:
NeuroImage: Clinical, Vol 39, Iss , Pp 103472- (2023)
Studying small effects or subtle neuroanatomical variation requires large-scale sample size data. As a result, combining neuroimaging data from multiple datasets is necessary. Variation in acquisition protocols, magnetic field strength, scanner build
Externí odkaz:
https://doaj.org/article/11627a88b0014d6dac1bebdeb37b7517
Autor:
Charles M. Laymon, Davneet S. Minhas, Sarah K. Royse, Howard J. Aizenstein, Ann D. Cohen, Dana L. Tudorascu, William E. Klunk
Publikováno v:
EJNMMI Physics, Vol 8, Iss 1, Pp 1-16 (2021)
Abstract Purpose Partial-volume correction (PVC) using the Geometric Transfer Matrix (GTM) method is used in positron emission tomography (PET) to compensate for the effects of spatial resolution on quantitation. We evaluate the effect of misspecific
Externí odkaz:
https://doaj.org/article/a1d9e289da664c3c87f10207989a723b
Autor:
Cécile Tissot, Joseph Therriault, Peter Kunach, Andréa L Benedet, Tharick A. Pascoal, Nicholas J. Ashton, Thomas K. Karikari, Stijn Servaes, Firoza Z. Lussier, Mira Chamoun, Dana L. Tudorascu, Jenna Stevenson, Nesrine Rahmouni, Nina Margherita Poltronetti, Vanessa Pallen, Gleb Bezgin, Min Su Kang, Sulantha S. Mathotaarachchi, Yi-Ting Wang, Jaime Fernandez Arias, Pamela Cristina Lukasewicz Ferreira, João Pedro Ferrari-Souza, Eugeen Vanmechelen, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Publikováno v:
EBioMedicine, Vol 76, Iss , Pp 103837- (2022)
Summary: Background: Tau in Alzheimer's disease (AD) is assessed via cerebrospinal fluid (CSF) and Positron emission tomography (PET). Novel methods to detect phosphorylated tau (pTau) in blood have been recently developed. We aim to investigate agre
Externí odkaz:
https://doaj.org/article/61fd198c9c7a4bc288c73fdc88da480b
Autor:
Austin M. Bazydlo, Matthew D. Zammit, Minjie Wu, Patrick J. Lao, Douglas C. Dean, III, Sterling C. Johnson, Dana L. Tudorascu, Ann Cohen, Karly A. Cody, Beau Ances, Charles M. Laymon, William E. Klunk, Shahid Zaman, Benjamin L. Handen, Sigan L. Hartley, Andrew L. Alexander, Bradley T. Christian
Publikováno v:
NeuroImage: Clinical, Vol 33, Iss , Pp 102908- (2022)
Introduction: Individuals with Down syndrome (DS) are at an increased risk of developing Alzheimer’s Disease (AD). One of the early underlying mechanisms in AD pathology is the accumulation of amyloid protein plaques, which are deposited in extrace
Externí odkaz:
https://doaj.org/article/158dd7b6ead14a7fb884d639927e63a9
Autor:
Mahbaneh Eshaghzadeh Torbati, Davneet S. Minhas, Ghasan Ahmad, Erin E. O’Connor, John Muschelli, Charles M. Laymon, Zixi Yang, Ann D. Cohen, Howard J. Aizenstein, William E. Klunk, Bradley T. Christian, Seong Jae Hwang, Ciprian M. Crainiceanu, Dana L. Tudorascu
Publikováno v:
NeuroImage, Vol 245, Iss , Pp 118703- (2021)
Modern neuroimaging studies frequently combine data collected from multiple scanners and experimental conditions. Such data often contain substantial technical variability associated with image intensity scale (image intensity scales are not the same
Externí odkaz:
https://doaj.org/article/186c8ae68de040a5866157a2a3e971a1
Autor:
Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian
Publikováno v:
NeuroImage, Vol 228, Iss , Pp 117728- (2021)
Introduction: Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and reveal early amyloid beta (Aβ) pathology in the brain. Positron emission tomography (PET) provides an in vivo measure of Aβ throughout the AD continuum. Du
Externí odkaz:
https://doaj.org/article/f793f64258bb45018fce502f5ace76f4
Autor:
Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Paul A. Ellison, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Marwan N. Sabbagh, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian
Publikováno v:
NeuroImage: Clinical, Vol 31, Iss , Pp 102740- (2021)
Introduction: Adults with Down syndrome are genetically predisposed to develop Alzheimer’s disease and accumulate beta-amyloid plaques (Aβ) early in life. While Aβ has been heavily studied in Down syndrome, its relationship with neurofibrillary t
Externí odkaz:
https://doaj.org/article/f466772638d948f6b49fdbd04232ca9b