Výsledky vyhledávání

Overcoming bioanalytical challenges associated with the separation and quantitation of GSK1278863, a HIF-prolyl hydroxylase inhibitor, and its 14 stereoisomeric metabolites

Autor: Dana Knecht, Christopher A. Evans, Hermes Licea Perez

Publikováno v: Journal of Chromatography B. :7-16

GSK1278863 is an investigative drug under investigation for treatment of anemia associated with chronic kidney disease. Its metabolism is primarily metabolized by P450 enzymes where 19 unique metabolic species have been identified. These include mult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872443b10c356d1957d3940e847ccc79
https://doi.org/10.1016/j.jchromb.2015.11.057

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Mass spectrometric characterization of a prolyl hydroxylase inhibitor GSK1278863, its bishydroxylated metabolite, and its implementation into routine doping controls

Autor: Dana Knecht, Hermes Licea-Perez, Wilhelm Schänzer, Susan Milosovich, Tom Cavalier, Mario Thevis

Publikováno v: Drug Testing and Analysis. 8:858-863

Drug candidates, which have the potential of enhancing athletic performance represent a risk of being misused in elite sport. Therefore, there is a need for early consideration by anti-doping authorities and implementation into sports drug testing pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4301ac66f9061692520d0e29ce23348
https://doi.org/10.1002/dta.1870

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Overcoming challenges associated with the bioanalysis of an ester prodrug and its active acid metabolite

Autor: Hermes Licea Perez, Maria Busz, Dana Knecht

Publikováno v: Bioanalysis. 9(20)

Aim: Bioanalysis of ester prodrugs represents a great analytical challenge due to poor matrix stability in the presence of esterases. Materials & methods: An approach that includes pH control, temperature and the use of an inhibitor (sodium fluoride,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784f43fa4be14b7c8b212f89fb9f1c5e
https://pubmed.ncbi.nlm.nih.gov/29072485

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Analytical approaches for quantification of a Nrf2 pathway activator: overcoming bioanalytical challenges to support a toxicity study

Autor: James F. Callahan, Hongxing Yan, Roderick S. Davis, Venkatraman Junnotula, Catherine Booth-Genthe, Hermes Licea Perez, Yolanda Sanchez, Hong Nie, Dana Knecht, Jeffrey C. Boehm

Publikováno v: The Analyst. 139:1902-1912

Activation of the Nrf2 stress pathway is known to play an important role in the defense mechanism against electrophilic and oxidative damage to biological macromolecules (DNA, lipids, and proteins). Chemical inducers of Nrf2 such as sulforaphane, dim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0886dc63f93eb7c0f448360a9e543ba6
https://doi.org/10.1039/c3an02216a

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Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation

Autor: Dana Knecht, Samuel C. Blackman, Kristen E Jurusik, Lauren E. Richards-Peterson, Peter D. Gorycki, Jerry L. Adams, Donna Mamaril-Fishman, David A. Bershas, Noelia Nebot, Royce A. Morrison, Stanley W. Carson, Daniele Ouellet

Publikováno v: Drug Metabolism and Disposition. 41:2215-2224

A phase I study was conducted to assess the metabolism and excretion of [(14)C]dabrafenib (GSK2118436; N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzene sulfonamide, methanesulfonate salt), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c9d2e4a5b1542ed07fbedd81036ccb
https://doi.org/10.1124/dmd.113.053785

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