Výsledky vyhledávání - "Dana J. Gant"

Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

Autor: Sally A. Frautschy, Emily R. Rosario, Ping-Ping Chen, Fusheng Yang, Beverly Hudspeth, Cory Chen, Dana J. Gant, Yongle Zhao, Greg M. Cole, Oliver J. Ubeda, Harry V. Vinters, Qiu-Lan Ma, Walter Beech

Publikováno v: Journal of Neuroscience. 29:9078-9089

Both insulin resistance (type II diabetes) and beta-amyloid (Abeta) oligomers are implicated in Alzheimer's disease (AD). Here, we investigate the role of Abeta oligomer-induced c-Jun N-terminal kinase (JNK) activation leading to phosphorylation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b935cb6c92dfd2fb01a4d9395432a08
https://doi.org/10.1523/jneurosci.1071-09.2009

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Loss of MAP Function Leads to Hippocampal Synapse Loss and Deficits in the Morris Water Maze with Aging

Autor: Fusheng Yang, Sean Nazari, Edmond Teng, Fatiha Nothias, Sally A. Frautschy, Ping-Ping Chen, Mher Alaverdyan, Qiu-Lan Ma, Dana J. Gant, Piu Chan, Nicolae C. Kiosea, Xiaohong Zuo, Greg M. Cole, Oliver J. Ubeda

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2014, 34 (21), pp.7124-7136. ⟨10.1523/JNEUROSCI.3439-13.2014⟩
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 34, iss 21
Journal of Neuroscience, 2014, 34 (21), pp.7124-7136. ⟨10.1523/JNEUROSCI.3439-13.2014⟩

International audience; Hyperphosphorylation and accumulation of tau aggregates are prominent features in tauopathies, including Alzheimer's disease, but the impact of loss of tau function on synaptic and cognitive deficits remains poorly understood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c54091330cde3ba0267e191c987a5c
https://hal.archives-ouvertes.fr/hal-01542860

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Curcumin Suppresses Soluble Tau Dimers and Corrects Molecular Chaperone, Synaptic, and Behavioral Deficits in Aged Human Tau Transgenic Mice*

Autor: Shuxin Hu, Fusheng Yang, Xiaohong Zuo, Bruce Teter, Qiu-Lan Ma, Ping-Ping Chen, Oliver J. Ubeda, Edmond Teng, Mher Alaverdyan, Panchanan Maiti, Dana J. Gant, Greg M. Cole, Sally A. Frautschy

The mechanisms underlying Tau-related synaptic and cognitive deficits and the interrelationships between Tau species, their clearance pathways, and synaptic impairments remain poorly understood. To gain insight into these mechanisms, we examined thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ad50d71b206324a54daf95f6fd83e9
https://europepmc.org/articles/PMC3567657/

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O3‐03‐04: Early intervention with docosahexanoic Acid (DHA) protects APOE4 acceleration of cognitive decline and plasma biomarkers in APOE4/5xFAD mice

Autor: Sally A. Frautschy, Mary Jo LaDu, Mher Alaverdyan, Greg M. Cole, Dana J. Gant, Fusheng Yang

Publikováno v: Alzheimer's & Dementia. 7

healthy elderly (age > 65) in WHICAP, a community-based and ethnically diverse cohort in New York. The associations between plasma As40 and As42 levels and calorie-adjusted dietary intake of 10 nutrients [saturated fatty acid (SFA), mono-unsaturated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75049ebd55eeacff05216d08eaebd3cc
https://doi.org/10.1016/j.jalz.2011.05.2403

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Attributional and relational processing in pigeons

Autor: Linda A. W. Brakel, Dennis Garlick, Aaron P. Blaisdell, Dana J. Gant

Publikováno v: Frontiers in Psychology, Vol 2 (2011)
Frontiers in Psychology
Frontiers in psychology, vol 2, iss FEB

Six pigeons were trained using a matching-to-sample procedure where sample and rewarded comparisons matched on both attributional (color) and relational (horizontal or vertical orientation) dimensions. Probes then evaluated the pigeons’ preference

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5e3f3245903d19a01008bf528cae84
http://journal.frontiersin.org/Journal/10.3389/fpsyg.2011.00014/full

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O3‐07‐02: Novel, small molecule inhibitors of protein aggregation for treatment of amyloid‐related diseases

Autor: Panchanan Maiti, Sally A. Frautschy, Cui-Wei Xie, Sharmistha Sinha, Aida Attar, Peter Talbiersky, Reena Bakshi, Shubhangi Prabhudesai, Gal Bitan, Frank-Gerrit Klärner, Thomas Schrader, Jeff M. Bronstein, Fusheng Yang, Mychica Jones, Miao Tan, Dana J. Gant, Pei-Yi Kuo

Publikováno v: Alzheimer's & Dementia. 6

Ab plaque burden. Catalytically incompetent 2E6 treated with a protease inhibitor and a non-proteolytic control IgVL2 did not express these activities. The major 2E6-cleavage site in Ab was the His14-Gln15 peptide bond. Epitope mapping indicated comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cfe53b7b34627887725432e05bb9087
https://doi.org/10.1016/j.jalz.2010.05.436

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