Zobrazeno 1 - 10
of 291
pro vyhledávání: '"Dana J, Philpott"'
Autor:
Paul Y. Bi, Samuel A. Killackey, Linus Schweizer, Damien Arnoult, Dana J. Philpott, Stephen E. Girardin
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Mitochondrial stress inducers such as carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and oligomycin trigger the DELE1-HRI branch of the integrated stress response (ISR) pathway. Previous studies performed using epitope-tagged DELE1 showed
Externí odkaz:
https://doaj.org/article/2c938dc33b884251b8cbcb518cef007c
Publikováno v:
Biomedical Journal, Vol 47, Iss 1, Pp 100637- (2024)
It has long been appreciated that cues from the innate immune system orchestrate downstream adaptive immune responses. Although previous work has focused on the roles of Toll-like receptors in this regard, relatively little is known about how Nod-lik
Externí odkaz:
https://doaj.org/article/a7d006034a1e456292fb5dc39c53310c
Autor:
Derek K.L. Tsang, Ryan J. Wang, Oliver De Sa, Arshad Ayyaz, Elisabeth G. Foerster, Giuliano Bayer, Shawn Goyal, Daniel Trcka, Bibaswan Ghoshal, Jeffrey L. Wrana, Stephen E. Girardin, Dana J. Philpott
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
The small intestinal epithelial barrier inputs signals from the gut microbiota in order to balance physiological inflammation and tolerance, and to promote homeostasis. Understanding the dynamic relationship between microbes and intestinal epithelial
Externí odkaz:
https://doaj.org/article/0018c12ca633427895fd121a96234369
Autor:
Qiaochu Lin, Meggie Kuypers, Zhewei Liu, Julia K Copeland, Donny Chan, Susan J Robertson, Jean Kontogiannis, David S Guttman, E. Kate Banks, Dana J Philpott, Thierry Mallevaey
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate-like functions and produce copious amounts of cytokines, chemokines and cytot
Externí odkaz:
https://doaj.org/article/545f76b4b1774dba9ea0db17924006eb
Autor:
Sarah E. Martchenko, David Prescott, Alexandre Martchenko, Maegan E. Sweeney, Dana J. Philpott, Patricia L. Brubaker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Intestinal functions demonstrate circadian rhythms thought to be entrained, in part, by an organisms’ intrinsic feeding and fasting periods as well as by the intestinal microbiome. Circadian disruption as a result of ill-timed nutrient exp
Externí odkaz:
https://doaj.org/article/df5c745531d4463cbc45706c3cba746e
Autor:
Parastoo Boroumand, David C Prescott, Tapas Mukherjee, Philip J Bilan, Michael Wong, Jeff Shen, Ivan Tattoli, Yuhuan Zhou, Angela Li, Tharini Sivasubramaniyam, Nancy Shi, Lucie Y Zhu, Zhi Liu, Clinton Robbins, Dana J Philpott, Stephen E Girardin, Amira Klip
Publikováno v:
eLife, Vol 11 (2022)
During obesity and high fat-diet (HFD) feeding in mice, sustained low-grade inflammation includes not only increased pro-inflammatory macrophages in the expanding adipose tissue, but also bone marrow (BM) production of invasive Ly6Chigh monocytes. As
Externí odkaz:
https://doaj.org/article/f814826c238d44d7839ebe163a29ca19
Autor:
Zach Dwyer, Melany Chaiquin, Jeffrey Landrigan, Kiara Ayoub, Pragya Shail, Julianna Rocha, Christie L. Childers, Kenneth B. Storey, Dana J. Philpott, Hongyu Sun, Shawn Hayley
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background Recent work has established that Parkinson’s disease (PD) patients have an altered gut microbiome, along with signs of intestinal inflammation. This could help explain the high degree of gastric disturbances in PD patients, as w
Externí odkaz:
https://doaj.org/article/ae51a5980fbe41598abca705b69ffe6e
Publikováno v:
BioTechniques, Vol 69, Iss 4, Pp 249-256 (2020)
Mitophagy is the process by which mitochondria are selectively targeted and removed via autophagic machinery to maintain mitochondrial homeostasis in the cell. Recently, flow cytometry-based assays that utilize the fluorescent mtKeima reporter system
Externí odkaz:
https://doaj.org/article/e22e909199ca4fd4a0f1d086eeefbedc
Autor:
Vikrant K. Bhosle, Tapas Mukherjee, Yi-Wei Huang, Sajedabanu Patel, Bo Wen (Frank) Pang, Guang-Ying Liu, Michael Glogauer, Jane Y. Wu, Dana J. Philpott, Sergio Grinstein, Lisa A. Robinson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Macrophages survey their surroundings using macropinocytosis, but its regulation is unclear. Here, the authors report that SLIT2, a known inhibitor of Rac GTPases, is an endogenous inhibitor of macropinocytosis, and that SLIT2 limits the uptake of NO
Externí odkaz:
https://doaj.org/article/155a4ff4159741ce9f07b911d6e0af13
Autor:
Elisabeth G. Foerster, Derek K.L. Tsang, Shawn Goyal, Susan J. Robertson, Lukian M. Robert, Heather Maughan, Catherine J. Streutker, Stephen E. Girardin, Dana J. Philpott
Publikováno v:
Mucosal Immunology. 16:135-152
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::315f6e63d72436e9f078caf8a8a95d9e
https://doi.org/10.1016/j.mucimm.2023.02.001
https://doi.org/10.1016/j.mucimm.2023.02.001