Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Dana Grebeňová"'
Publikováno v:
HemaSphere, Vol 7, p e60469b2 (2023)
Externí odkaz:
https://doaj.org/article/3b403be69c13441e99db7f13bfb40276
Autor:
Markéta Šašinková, Petr Heřman, Aleš Holoubek, Dita Strachotová, Petra Otevřelová, Dana Grebeňová, Kateřina Kuželová, Barbora Brodská
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Nucleophosmin (NPM) mutations causing its export from the nucleoli to the cytoplasm are frequent in acute myeloid leukemia (AML). Due to heterooligomerization of wild type NPM with the AML-related mutant, the wild-type becomes misplaced from
Externí odkaz:
https://doaj.org/article/1b474fa87d0546bcb278d14120b4631c
Autor:
Kateřina Kuželová, Adam Obr, Pavla Röselová, Dana Grebeňová, Petra Otevřelová, Barbora Brodská, Aleš Holoubek
Publikováno v:
Cell Adhesion & Migration, Vol 15, Iss 1, Pp 18-36 (2021)
P21-activated kinases (PAK) regulate processes associated with cytoskeleton dynamics. PAK expression in leukemia cells was measured on protein and mRNA levels. In functional assays, we analyzed the effect of PAK inhibitors IPA-3 and FRAX597 on cell a
Externí odkaz:
https://doaj.org/article/6f33218842564496b968fccacc0c857b
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92560 (2014)
P21-activated kinases (PAKs) are involved in the regulation of multiple processes including cell proliferation, adhesion and migration. However, the current knowledge about their function is mainly based on results obtained in adherent cell types. We
Externí odkaz:
https://doaj.org/article/578b53d0109642888ce488b2fb2ad241
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107367 (2014)
Attachment of stem leukemic cells to the bone marrow extracellular matrix increases their resistance to chemotherapy and contributes to the disease persistence. In chronic myelogenous leukemia (CML), the activity of the fusion BCR-ABL kinase affects
Externí odkaz:
https://doaj.org/article/4504acd233fb4bcd802538c2c934dcc7
P21-activated kinases (PAKs) regulate processes associated with cytoskeletal rearrangements, such as cell division, adhesion, and migration. The possible regulatory role of PAKs in cell metabolism has not been well explored, but increasing evidence s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d055de2831d865e7044b5ad64b517a
https://doi.org/10.1101/2021.05.18.444625
https://doi.org/10.1101/2021.05.18.444625
Publikováno v:
Cell Adhesion & Migration. 7:275-282
Real-time cell analysis (RTCA) system based on measurement of electrical microimpedance has been introduced to monitor adherent cell cultures. We describe its use for real-time analysis of hematopoietic cell adhesion to bone marrow stroma proteins. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90c8fdf8a1552b1a957c0b0b1310995f
https://doi.org/10.4161/cam.24531
https://doi.org/10.4161/cam.24531
Interaction of leukemia blasts with the bone marrow extracellular matrix often results in protection of leukemia cells from chemotherapy and in persistence of the residual disease which is on the basis of subsequent relapses. The adhesion signaling p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f8e7e59f187258a524de2f91dbf8b5
Autor:
Michaela Pluskalová, K. Pavlásková, Dana Grebeňová, Kateřina Kuželová, Zbyněk Hrkal, Petr Halada
Publikováno v:
Journal of Cellular Biochemistry. 111:1413-1425
The fusion protein Bcr–Abl, which is the molecular cause of chronic myelogenous leukemia (CML) interacts in multiple points with signaling pathways regulating the cellular adhesivity and cytoskeleton architecture and dynamics. We explored the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d75b8f7243d464e00148ae7d3d7bab
https://doi.org/10.1002/jcb.22868
https://doi.org/10.1002/jcb.22868
Autor:
Kateřina Kuželová, Zbyněk Hrkal, Barbora Brodská, Michaela Pluskalová, Dana Grebeňová, Klára Elknerová, Petra Otevřelová
Publikováno v:
Journal of Cellular Biochemistry. 109:184-195
Suberoylanilide hydroxamic acid (SAHA) is an inhibitor of histone deacetylases (HDACs) which is being introduced into clinic for the treatment of hematological diseases. We studied the effect of this compound on six human hematopoietic cell lines (JU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5811671143af4ce5f6f8bfe9c7c547bf
https://doi.org/10.1002/jcb.22397
https://doi.org/10.1002/jcb.22397