Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Dana Gášková"'
Publikováno v:
BioTechniques, Vol 50, Iss 1, Pp 58-63 (2011)
New antifungal agents are needed to treat life-threatening fungal infections, particularly with the development of resistance. Surface-active antifungals have the advantages of minimizing host toxicity and the emergence of drug resistance. We have de
Externí odkaz:
https://doaj.org/article/a95dcce452194102939b5644b4caca76
Publikováno v:
Microbial Drug Resistance. 25:805-812
Aim: This work studied the impact of the quorum-sensing molecule, farnesol (FAR), on fluconazole (FLC)-resistant Candida albicans isolate CY 1123 compared with the susceptible standard strain C. al...
Publikováno v:
Microbial drug resistance (Larchmont, N.Y.). 25(6)
Autor:
Marcela Morvová, Alexandra Bencova, Yvetta Gbelska, Nora Toth Hervay, Iva Jančíková, Dana Gášková, Alexandra Konecna, L. Šikurová
Publikováno v:
FEMS Microbiology Letters. 365
We investigated the effect of Kluyveromyces lactis ERG6 gene deletion on plasma membrane function and showed increased susceptibility of mutant cells to salt stress, cationic drugs and weak organic acids. Contrary to Saccharomyces cerevisiae, Klerg6
Publikováno v:
Analytical Chemistry. 87:9600-9604
Since its introduction in 1998, genetically encoded pH-sensitive sensor ratiometric pHluorin proved to be a valuable tool for cell physiology studies. Here, we show how the sensitivity of pHluorin-based monitoring of intracellular pH changes performe
Autor:
Dana Gášková, Marcela Morvová, Yvetta Gbelska, Peter Griac, Iva Jančíková, Nora Toth Hervay, Zuzana Šimová, Eduard Goffa, Alexandra Svrbicka, L. Šikurová
Publikováno v:
Canadian Journal of Microbiology. 61:273-279
The plasma membrane is the first line of cell defense against changes in external environment, thus its integrity and functionality are of utmost importance. The plasma membrane properties depend on both its protein and lipid composition. The PDR16 g
Publikováno v:
FEMS Yeast Research. 17
Multidrug transporters are often responsible for failure of medical treatment, since they expel a variety of structurally and functionally unrelated drugs out of the cell. We found that the fluorescent probe diS-C3(3) is a substrate of not only Pdr5p
Autor:
Stanislava Dižová, Iva Jančíková, Zuzana Ježíková, Barbora Pfeiferová, Helena Bujdáková, Dana Gášková, Tomáš Pagáč, Petra Olejníková
Publikováno v:
Antonie van Leeuwenhoek. 110(9)
With emerging fungal infections and developing resistance, there is a need for understanding the mechanisms of resistance as well as its clinical impact while planning the treatment strategies. Several approaches could be taken to overcome the proble
Autor:
Karel Sigler, Andrea Svenkrtova, Otakar Hlaváček, Dana Gášková, Tomáš Hendrych, Iva Jančíková, Jakub Zahumenský, Jaromír Plášek, Andrea Drietomská
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1859(10)
Tok1p is a highly specific yeast plasma membrane potassium channel with strong outward directionality. Its opening is induced by membrane depolarization. Although the biophysical properties of Tok1p are well-described, its potentially important physi
Publikováno v:
Journal of bioenergetics and biomembranes. 49(3)
Yeast cells exhibit a negative surface potential due to negative charges at the cell membrane surface. Consequently, local concentrations of cations at the periplasmic membrane surface may be significantly increased compared to their bulk environment