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Akademický článek

Identification of small molecule activators of BMP signaling.

Autor: Karen Vrijens, Wenwei Lin, Jimmy Cui, Dana Farmer, Jonathan Low, Elodie Pronier, Fu-Yue Zeng, Anang A Shelat, Kiplin Guy, Michael R Taylor, Taosheng Chen, Martine F Roussel

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e59045 (2013)

Bone Morphogenetic Proteins (BMPs) are morphogens that play a major role in regulating development and homeostasis. Although BMPs are used for the treatment of bone and kidney disorders, their clinical use is limited due to the supra-physiological do

Externí odkaz: https://doaj.org/article/2a0ffbcf0f434c0b907c4a00a3cd6a60

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OMIC-03. TRANSLATIONAL CONTROL IN MYC AND MYCN MEDULLOBLASTOMA

Autor: Christin Schmidt, Bjoern Schwer, William A. Weiss, Dana Farmer, Martine F. Roussel, Albertas Navickas, Frederique Zindy, Hani Goodarzi, Davide Ruggero

Publikováno v: Neuro-Oncology

Medulloblastoma has been extensively characterized at the genomic and transcriptional levels, but little is known about how alterations in translational control underlie tumor development. Myc and Mycn are often deregulated in medulloblastoma and pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d0ce8b55f8b61a30bf3d2a7f0a5435
http://europepmc.org/articles/PMC8168149

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Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway

Autor: David B. Finkelstein, Karen Vrijens, Taosheng Chen, Jose Grenet, Jaeki Min, Wilson K. Clements, R. Kiplin Guy, Anang A. Shelat, Wenwei Lin, Martine F. Roussel, Dana Farmer, Jamie R. Genthe

Publikováno v: ACS Chemical Biology. 12:2436-2447

Here we describe three new small-molecule activators of BMP signaling found by high throughput screening of a library of ~600,000 small molecules. Using a cell-based luciferase assay in the BMP4-responsive human cervical carcinoma clonal cell line, C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed17e46933d04c11e1617f89be76eae
https://doi.org/10.1021/acschembio.7b00527

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CNS penetration and pharmacodynamics of the CHK1 inhibitor prexasertib in a mouse Group 3 medulloblastoma model

Autor: Dana Farmer, Bo Zhong, Jennifer L. Stripay, Clinton F. Stewart, Martine F. Roussel, Abigail D. Davis, Olivia Campagne, Anil R. Maharaj

Publikováno v: Eur J Pharm Sci

Prexasertib (LY2606368) is a potent and selective small molecule inhibitor of cell-cycle checkpoint CHK1 and CHK2 protein kinases and is currently under clinical evaluation for treatment of pediatric malignancies. As a candidate therapy for pediatric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b448d09b6bb589e9618383c45d88b1df
https://pubmed.ncbi.nlm.nih.gov/31669383

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A possible bichromatid mutation in a male gamete giving rise to a female mosaic for two different mutations in the X-linked gene WAS

Autor: A. K. Dobbs, Mary Ellen Conley, T Yang, Vanessa Howard, Dana Farmer

Publikováno v: Clinical Genetics. 71:171-176

In genetic disorders caused by point mutations or small frameshift mutations, affected members of the same family are expected to have the same mutation in the causative gene. We have recently evaluated a family in which this was not the case. Matern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2952fc7ac4fb95eab6c1083617092b3a
https://doi.org/10.1111/j.1399-0004.2007.00748.x

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Identification of small molecule activators of BMP signaling

Autor: Kiplin R. Guy, Taosheng Chen, Jonathan Low, Jimmy Cui, Wenwei Lin, Karen Vrijens, Anang A. Shelat, Fu-Yue Zeng, Dana Farmer, Martine F. Roussel, Michael R. Taylor, Elodie Pronier

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e59045 (2013)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a522328616884667aa159e582b8dded
http://europepmc.org/articles/PMC3602516?pdf=render

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Primary B cell immunodeficiencies: comparisons and contrasts

Autor: Mary Ellen Conley, Kenneth Paris, Vanessa Howard, Elaine Coustan-Smith, Sofia Grigoriadou, Dana Farmer, A. Kerry Dobbs, Dario Campana, Sebnem Kilic

Publikováno v: Annual review of immunology. 27

Sophisticated genetic tools have made possible the identification of the genes responsible for most well-described immunodeficiencies in the past 15 years. Mutations in Btk, components of the pre-B cell and B cell receptor (λ5, Igα, Igβ), or the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c8be132a502876665c5101b5822157
https://pubmed.ncbi.nlm.nih.gov/19302039

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A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease

Autor: Vanessa Howard, Yuichi Aiba, Tomohiro Kurosaki, Mary Ellen Conley, A. K. Dobbs, Sheila A. Shurtleff, Dana Farmer

SummaryReduced B cell numbers and a mutation in Btk are considered sufficient to make the diagnosis of X-linked agammaglobulinaemia. In the process of conducting family studies, we identified a 58-year-old healthy man with an amino acid substitution,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fabd086ed80661982b02871c569c31d
https://europepmc.org/articles/PMC2384053/

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Cutting edge: a hypomorphic mutation in Igbeta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development

Autor: Ornella Parolini, Leo Kager, Mary Ellen Conley, A. Kerry Dobbs, Tianyu Yang, Dana Farmer

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 179(4)

Although null mutations in Igα have been identified in patients with defects in B cell development, no mutations in Igβ have been reported. We recently identified a patient with a homozygous amino acid substitution in Igβ, a glycine to serine at c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a10ebae8c6c145b9565e4574d5d1ed7
https://pubmed.ncbi.nlm.nih.gov/17675462

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Akademický článek

The Role of Positron Emission Tomography and Computed Tomographic (PET/CT) Imaging for Radiation Therapy Planning: A Literature Review.

Autor: Mallum A; Department of Radiotherapy and Oncology, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.; Department of Radiotherapy and Oncology, Inkosi Albert Luthuli Central Hospital, Durban 4091, South Africa.; University of Maiduguri Teaching Hospital, Maiduguri 600104, Nigeria., Mkhize T; Department of Nuclear Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.; Department of Nuclear Medicine, Inkosi Albert Central Hospital, Durban 4091, South Africa., Akudugu JM; Division of Radiobiology, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa., Ngwa W; School of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.; Brigham and Women's Hospital, Dana-Farmer Cancer Institute, Harvard Medical School, Boston, MA 02115, USA., Vorster M; Department of Nuclear Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.; Department of Nuclear Medicine, Inkosi Albert Central Hospital, Durban 4091, South Africa.

Publikováno v: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2022 Dec 24; Vol. 13 (1). Date of Electronic Publication: 2022 Dec 24.

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