Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm

Autor: Yuchao Jiang, Cheng Luo, Jijun Wang, Lena Palaniyappan, Xiao Chang, Shitong Xiang, Jie Zhang, Mingjun Duan, Huan Huang, Christian Gaser, Kiyotaka Nemoto, Kenichiro Miura, Ryota Hashimoto, Lars T. Westlye, Genevieve Richard, Sara Fernandez-Cabello, Nadine Parker, Ole A. Andreassen, Tilo Kircher, Igor Nenadić, Frederike Stein, Florian Thomas-Odenthal, Lea Teutenberg, Paula Usemann, Udo Dannlowski, Tim Hahn, Dominik Grotegerd, Susanne Meinert, Rebekka Lencer, Yingying Tang, Tianhong Zhang, Chunbo Li, Weihua Yue, Yuyanan Zhang, Xin Yu, Enpeng Zhou, Ching-Po Lin, Shih-Jen Tsai, Amanda L. Rodrigue, David Glahn, Godfrey Pearlson, John Blangero, Andriana Karuk, Edith Pomarol-Clotet, Raymond Salvador, Paola Fuentes-Claramonte, María Ángeles Garcia-León, Gianfranco Spalletta, Fabrizio Piras, Daniela Vecchio, Nerisa Banaj, Jingliang Cheng, Zhening Liu, Jie Yang, Ali Saffet Gonul, Ozgul Uslu, Birce Begum Burhanoglu, Aslihan Uyar Demir, Kelly Rootes-Murdy, Vince D. Calhoun, Kang Sim, Melissa Green, Yann Quidé, Young Chul Chung, Woo-Sung Kim, Scott R. Sponheim, Caroline Demro, Ian S. Ramsay, Felice Iasevoli, Andrea de Bartolomeis, Annarita Barone, Mariateresa Ciccarelli, Arturo Brunetti, Sirio Cocozza, Giuseppe Pontillo, Mario Tranfa, Min Tae M. Park, Matthias Kirschner, Foivos Georgiadis, Stefan Kaiser, Tamsyn E. Van Rheenen, Susan L. Rossell, Matthew Hughes, William Woods, Sean P. Carruthers, Philip Sumner, Elysha Ringin, Filip Spaniel, Antonin Skoch, David Tomecek, Philipp Homan, Stephanie Homan, Wolfgang Omlor, Giacomo Cecere, Dana D. Nguyen, Adrian Preda, Sophia I. Thomopoulos, Neda Jahanshad, Long-Biao Cui, Dezhong Yao, Paul M. Thompson, Jessica A. Turner, Theo G. M. van Erp, Wei Cheng, ENIGMA Schizophrenia Consortium, Jianfeng Feng, ZIB Consortium

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy su

Externí odkaz: https://doaj.org/article/76bdd81832814fb8a0f1d01e09c35de4

D2receptor occupancy following lurasidone treatment in patients with schizophrenia or schizoaffective disorder

Autor: David Keator, Marilyn L Kesler-West, Jogeshwar Mukherjee, Nikunj Shah, Steven G. Potkin, Adrian Preda, Theo G.M. van Erp, Dana D Nguyen

Publikováno v: CNS Spectrums. 19:176-181

Objective/IntroductionLurasidone is an atypical antipsychotic medication approved for the treatment of schizophrenia over a dose range of 40–160 mg/day. This study examined D2receptor occupancy and its association with clinical improvement and side

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6424e9c05d0fd1423cdf027080ae6b90
https://doi.org/10.1017/s109285291300059x

Waist circumference does not predict insulin resistance in African American schizophrenia patients

Autor: David C. Henderson, Bernice B. Rumala, Sharon Forstbauer, Leah B. Namey Briggs, Kate Miley, Christina P.C. Borba, Dana D. Nguyen, Bikash Sharma, Xiaoduo Fan

Publikováno v: International Journal of Culture and Mental Health. 1:93-104

The objective of the study was to determine whether race plays a role in the relationship between waist circumference and insulin resistance in an African American and white sample of subjects with schizophrenia. A cross-sectional comparison was cond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33bb65fcf2034ed0ad330b5ac7022f37
https://doi.org/10.1080/17542860802201117

Higher Fasting Serum Insulin Is Associated with Increased Resting Energy Expenditure in Nondiabetic Schizophrenia Patients

Autor: Donald C. Goff, Xiaoduo Fan, David C. Henderson, Christina P.C. Borba, Paul M. Copeland, Oliver Freudenreich, Ellen J. Anderson, Dana D. Nguyen

Publikováno v: Biological Psychiatry. 60:1372-1377

Background Insulin has emerged as an important determinant of food intake, energy expenditure, and weight control. This study examined the relationship between fasting serum insulin level and resting energy expenditure (REE) in a cross-sectional samp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cf8b2afdd320a69f893615208a30fb
https://doi.org/10.1016/j.biopsych.2006.05.006

A double-blind, placebo-controlled trial of sibutramine for clozapine-associated weight gain

Autor: Haiyue Zhang, Tara B. Daley, Xiaoduo Fan, David C. Henderson, A. E. Evins, Oliver Freudenreich, Dana D. Nguyen, Christina P.C. Borba, Doug Hayden, Paul M. Copeland, Corinne Cather, Donald C. Goff

Publikováno v: Acta psychiatrica Scandinavica. 115(2)

Objective: Weight gain is commonly observed with olanzapine treatment and can increase the risk for obesity, cardiovascular disease, hypertension, and diabetes mellitus. This study examined the effectiveness of sibutramine, an approved weight loss ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82bd8e9b73a7625a5117961eae20b46b
https://pubmed.ncbi.nlm.nih.gov/17244173