Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Dana Brantley‐Sieders"'
Autor:
Verra Ngwa, Dominique Parker, Xiaoyong Wang, Deanna Edwards, Dana Brantley-Sieders, Julie Rhoades, Jin Chen
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100588- (2024)
Externí odkaz:
https://doaj.org/article/4638e8781bbc4ec2a220adac0f21dfc7
Autor:
David B Vaught, Alyssa R Merkel, Conor C Lynch, James Edwards, Mohammed Noor Tantawy, Timothy Hilliard, Shan Wang, Todd Peterson, Rachelle W Johnson, Julie A Sterling, Dana Brantley‐Sieders
Publikováno v:
JBMR Plus, Vol 5, Iss 4, Pp n/a-n/a (2021)
ABSTRACT EphA2 receptor tyrosine kinase (RTK) is highly expressed in breast tumor cells across multiple molecular subtypes and correlates with poor patient prognosis. In this study, the potential role of EphA2 in this clinically relevant phenomenon i
Externí odkaz:
https://doaj.org/article/e50828c08fb84f00868df19ee24dc038
Autor:
Meghan Morrison Joly, Michelle M. Williams, Donna J. Hicks, Bayley Jones, Violeta Sanchez, Christian D. Young, Dos D. Sarbassov, William J. Muller, Dana Brantley-Sieders, Rebecca S. Cook
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-15 (2017)
Abstract Background The importance of the mTOR complex 2 (mTORC2) signaling complex in tumor progression is becoming increasingly recognized. HER2-amplified breast cancers use Rictor/mTORC2 signaling to drive tumor formation, tumor cell survival and
Externí odkaz:
https://doaj.org/article/398ec463dfb44d96a8fde76022898ffd
Autor:
Meghana Rao, Wenqiang Song, Aixiang Jiang, Yu Shyr, Sima Lev, David Greenstein, Dana Brantley-Sieders, Jin Chen
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46281 (2012)
VAPB (VAMP- associated protein B) is an ER protein that regulates multiple biological functions. Although aberrant expression of VAPB is associated with breast cancer, its function in tumor cells is poorly understood. In this report, we provide evide
Externí odkaz:
https://doaj.org/article/c456849875e644b7b54b3b484434ae20
Autor:
Rebecca S. Cook, Dana Brantley-Sieders, William J. Muller, Dos D. Sarbassov, Brent N. Rexer, Michelle Williams, Christian Young, Monica Valeria Estrada, Violeta Sanchez, Bayley Jones, Donna J. Hicks, Meghan Morrison Joly
HER2 overexpression drives Akt signaling and cell survival and HER2-enriched breast tumors have a poor outcome when Akt is upregulated. Akt is activated by phosphorylation at T308 via PI3K and S473 via mTORC2. The importance of PI3K-activated Akt sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab951660734178401918fe34c45e10e
https://doi.org/10.1158/0008-5472.c.6507966.v1
https://doi.org/10.1158/0008-5472.c.6507966.v1
Autor:
Rebecca S. Cook, Dana Brantley-Sieders, William J. Muller, Dos D. Sarbassov, Brent N. Rexer, Michelle Williams, Christian Young, Monica Valeria Estrada, Violeta Sanchez, Bayley Jones, Donna J. Hicks, Meghan Morrison Joly
Supplemental Figure Legends and Supplemental tables (Table 1 and table 2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad4196337a29495117d406fd151d65c
https://doi.org/10.1158/0008-5472.22410321
https://doi.org/10.1158/0008-5472.22410321
Autor:
Rebecca S. Cook, Dana Brantley-Sieders, William J. Muller, Dos D. Sarbassov, Brent N. Rexer, Michelle Williams, Christian Young, Monica Valeria Estrada, Violeta Sanchez, Bayley Jones, Donna J. Hicks, Meghan Morrison Joly
Supplemental Figure S1. Kaplan meier analysis and oncoprint mapping of Luminal A/B (A) and Basal-like (B) TCGA-curated breast cancers, showing the tumors in each set with upregulation of Akt1/2/3 mRNA (red boxes) or phospho-S473 (black arrows), and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f52d4e20d7a1729d62607c0c89b332
https://doi.org/10.1158/0008-5472.22410318.v1
https://doi.org/10.1158/0008-5472.22410318.v1
PDF file - 612K, Knockdown of EPHA2 inhibits cell viability and tumor cell migration in NSCLC cells (S1); Effects of EPHA2 on JNK and c-JUN expression and activities in NSCLCs (S2); SP600125 inhibits phosphorylation of JNK and c-JUN and cell viabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256941c468e5ac5d09a1382b3060d8a7
https://doi.org/10.1158/0008-5472.22401158.v1
https://doi.org/10.1158/0008-5472.22401158.v1
Recent genome-wide analyses in human lung cancer revealed that EPHA2 receptor tyrosine kinase is overexpressed in non–small cell lung cancer (NSCLC), and high levels of EPHA2 correlate with poor clinical outcome. However, the mechanistic basis for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a7e2b4294a14e5a4e4322127bd6dfd4
https://doi.org/10.1158/0008-5472.c.6505778
https://doi.org/10.1158/0008-5472.c.6505778