Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Dan Y. Gui"'
Autor:
Mark R Sullivan, Laura V Danai, Caroline A Lewis, Sze Ham Chan, Dan Y Gui, Tenzin Kunchok, Emily A Dennstedt, Matthew G Vander Heiden, Alexander Muir
Publikováno v:
eLife, Vol 8 (2019)
Cancer cell metabolism is heavily influenced by microenvironmental factors, including nutrient availability. Therefore, knowledge of microenvironmental nutrient levels is essential to understand tumor metabolism. To measure the extracellular nutrient
Externí odkaz:
https://doaj.org/article/9527455619a74344a76fc049642a495d
Autor:
Alexander Muir, Laura V Danai, Dan Y Gui, Chiara Y Waingarten, Caroline A Lewis, Matthew G Vander Heiden
Publikováno v:
eLife, Vol 6 (2017)
Many mammalian cancer cell lines depend on glutamine as a major tri-carboxylic acid (TCA) cycle anaplerotic substrate to support proliferation. However, some cell lines that depend on glutamine anaplerosis in culture rely less on glutamine catabolism
Externí odkaz:
https://doaj.org/article/8a1514f9938a468fae8183d82087eadd
Autor:
Mark R. Sullivan, Caroline A. Lewis, Dan Y. Gui, Sze Ham Chan, Matthew G. Vander Heiden, Tenzin Kunchok, Alexander Muir, Emily A Dennstedt, Laura V. Danai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaaaeea0817b2fcb22abaf6d69327952
https://doi.org/10.7554/elife.44235.047
https://doi.org/10.7554/elife.44235.047
Autor:
Adi Naamati, Craig J. Thomas, Dan Y. Gui, Maria Zagorulya, Lucas B. Sullivan, Alba Luengo, Stefani Spranger, Nicholas J Matheson, Matthew G. Vander Heiden, Ahmed Ali, Raphael Ferreira, Caroline A. Lewis, Zhaoqi Li, Brian T. Do
Publikováno v:
Mol Cell
Elsevier
Elsevier
Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is a hallmark of proliferative metabolism that is observed across many organisms and conditions. To better understand why aerobic glycol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87fae0ba74cac70692921971c77fca4
https://doi.org/10.1016/j.molcel.2020.12.012
https://doi.org/10.1016/j.molcel.2020.12.012
Autor:
Kerry A. Pierce, Gregory Stephanopolous, Dan Y. Gui, Lakshmipriya Subbaraj, Mark A. Keibler, Tyler Jacks, Thales Papagiannakopoulos, Bryan T. Mott, Lucas B. Sullivan, Clary B. Clish, Thomas M. Wasylenko, Matthew G. Vander Heiden, Matthew R. Bauer, Alba Luengo, James P. O’Brien, Abhishek K. Jha, Shawn M. Davidson, Benjamin A. Olenchock, Christopher R. Chin, Julia E. Heyman
Publikováno v:
PMC
Cultured cells convert glucose to lactate, and glutamine is the major source of tricarboxylic acid (TCA)-cycle carbon, but whether the same metabolic phenotype is found in tumors is less studied. We infused mice with lung cancers with isotope-labeled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de6a0e1b2ca0fee202deb10989c8a59
Publikováno v:
PMC
The role of pyruvate kinase M2 (PKM2) in cell proliferation is controversial. A unique function of PKM2 proposed to be important for the proliferation of some cancer cells involves the direct activity of this enzyme as a protein kinase; however, a de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7d16bddfcefd5711cf117363e1f3ce
https://doi.org/10.1016/j.molcel.2015.07.013
https://doi.org/10.1016/j.molcel.2015.07.013
Autor:
Aaron M. Hosios, Dan Y. Gui, Matthew G. Vander Heiden, Lauren N. Bush, Lucas B. Sullivan, Elizaveta Freinkman
Publikováno v:
Cell. 162:552-563
SummaryMitochondrial respiration is important for cell proliferation; however, the specific metabolic requirements fulfilled by respiration to support proliferation have not been defined. Here, we show that a major role of respiration in proliferatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a96f1a6a9c72ef2e0fe77258ac565ef
https://doi.org/10.1016/j.cell.2015.07.017
https://doi.org/10.1016/j.cell.2015.07.017
Autor:
Dan Y. Gui, Chiara Y Waingarten, Caroline A. Lewis, Matthew G. Vander Heiden, Alexander Muir, Laura V. Danai
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Many mammalian cancer cell lines depend on glutamine as a major tri-carboxylic acid (TCA) cycle anaplerotic substrate to support proliferation. However, some cell lines that depend on glutamine anaplerosis in culture rely less on glutamine catabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca467259a1ef1f5dc2cec4f14509dac
http://europepmc.org/articles/PMC5589418
http://europepmc.org/articles/PMC5589418
Publikováno v:
Cell chemical biology. 24(9)
Metabolic reprogramming contributes to tumor development and introduces metabolic liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have been effective cancer treatments for decades, and the success of these thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1e3cf6845d85928f31f7f1a8139f06
https://pubmed.ncbi.nlm.nih.gov/28938091
https://pubmed.ncbi.nlm.nih.gov/28938091