Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Dan Waid"'
Autor:
Gisela Vaitaitis, Tracy Webb, Craig Webb, Christina Sharkey, Steve Sharkey, Dan Waid, David H. Wagner
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionCanine diabetes mellitus (CDM) is a relatively common endocrine disease in dogs. Many CDM clinical features resemble human type 1 diabetes mellitus (T1DM), but lack of autoimmune biomarkers makes calling the disease autoimmune controversi
Externí odkaz:
https://doaj.org/article/3a8c6eaa48734fe78d1fd4f3e9f3ff95
Autor:
Christian Curran, Gisela Vaitaitis, Dan Waid, Timothy Volmer, Enrique Alverez, David H. Wagner
Publikováno v:
Journal of Neuroimmunology. 374:578008
Treating MS has been difficult. One successful drug is Ocrelizumab (anti-CD20), used for the chronic relapsing MS (RMS) and the progressive MS (PMS) forms. TH40 cells are pathogenic effector T cells that increase in percentage and numbers during chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16cd634d3ebd7e0ee1152a67d282e2f
https://doi.org/10.1016/j.jneuroim.2022.578008
https://doi.org/10.1016/j.jneuroim.2022.578008
Publikováno v:
Journal of the Endocrine Society. 6:A296-A296
Canine Diabetes (CD) is identical to human T1DM. Helper T cells expressing the CD40 receptor (TH40) are prominent in human T1DM. TH40 cell expansions occur regardless of HLA haplotype or auto-antibody status and remain elevated throughout disease. TH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30a24340146fe9378100e933172e3e24
https://doi.org/10.1210/jendso/bvac150.611
https://doi.org/10.1210/jendso/bvac150.611
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Sustained inflammation is a crucial pathologic component in atherosclerosis and type 2 diabetes (T2D). A common molecular player driving auto-inflammation in both diseases is the CD40/CD154 inflammatory dyad. By normalizing the aberrant contact depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89b1585593a84c16d73083bdac729c40
https://doi.org/10.1161/atvb.38.suppl_1.189
https://doi.org/10.1161/atvb.38.suppl_1.189
Publikováno v:
The Journal of Immunology. 202:115.4-115.4
The incidence of Type 1 Diabetes (T1D) is on the rise. Quests to understand T1D etiology as well as how to predict onset are ongoing and, in many ways, those goals intertwine. CD4+CD40+ T cell (Th40) percentages are expanded in T1D subjects compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bb9609d104fe0e8768053a9b82076fb
https://doi.org/10.4049/jimmunol.202.supp.115.4
https://doi.org/10.4049/jimmunol.202.supp.115.4
Publikováno v:
The Journal of Immunology. 194:184.5-184.5
The CD40-CD154 dyad is critically involved in autoimmune diseases including Multiple Sclerosis (MS) and Type 1 Diabetes (T1D). CD4+CD40+ T cells, Th40, are necessary and sufficient to establish T1D in the mouse model. In the Experimental Autoimmune E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b2baadb6c5b76ee1f407986a70f5d8f
https://doi.org/10.4049/jimmunol.194.supp.184.5
https://doi.org/10.4049/jimmunol.194.supp.184.5
Publikováno v:
The Journal of Immunology. 194:121.25-121.25
Multiple Sclerosis is a neurodegenerative disease with autoimmune components. Diagnosis is invasive and time consuming. The etiology is unclear as are clues for disease progression. The autoimmune components have largely been defined in the EAE mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffa5fe8426f11b2b38e6e268f6b7cebf
https://doi.org/10.4049/jimmunol.194.supp.121.25
https://doi.org/10.4049/jimmunol.194.supp.121.25
Publikováno v:
The Journal of Immunology. 192:200.17-200.17
CD40-CD154 interaction is decisive in directing autoimmune inflammation; therefore, controlling this interaction and hence destructive inflammation is a major goal in a number of autoimmune diseases including Type 1 Diabetes (T1D). Initial attempts t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39cb978756ec7525740033a2ab7a51fe
https://doi.org/10.4049/jimmunol.192.supp.200.17
https://doi.org/10.4049/jimmunol.192.supp.200.17
Publikováno v:
The Journal of Immunology. 190:43.22-43.22
Multiple sclerosis (MS) is a neurodegenerative disease with established autoimmune components. We described a unique T cell subset expressing CD40, Th40 cells that achieve effector status in autoimmune diseases. Furthermore we discovered that Th40 ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feb041f0aff7bb4ec02ba4c01f8d504a
https://doi.org/10.4049/jimmunol.190.supp.43.22
https://doi.org/10.4049/jimmunol.190.supp.43.22
Publikováno v:
The Journal of Immunology. 188:171.38-171.38
Multiple sclerosis is a neurodegenerative disease with strong evidence for autoimmune components. Auto-aggressive T cells are implicated in the pathogenesis and maintenance of the disease in both mouse models and human disease. We described a T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1c57365bcb12a7b38054d8361bea6c0
https://doi.org/10.4049/jimmunol.188.supp.171.38
https://doi.org/10.4049/jimmunol.188.supp.171.38