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pro vyhledávání: '"Dan W. Harmer"'
5-HT2B receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro
Autor:
R. L. G. Sheldrick, R.A. Coleman, E.S. Ellis, Dan W. Harmer, J. Carey, Baxter Gordon Smith, N. Day, Nick Tilford, R. A. Borman
Publikováno v:
British Journal of Pharmacology. 135:1144-1151
5-Hydroxytryptamine (5-HT) is known to produce a number of different effects in the gastrointestinal tract of various species, and has been proposed to play a key role in a number of intestinal disorders in man, including irritable bowel syndrome (IB
Publikováno v:
Physiological genomics. 21(3)
Quantitative gene expression data are often normalized to the expression levels of control or so-called “housekeeping” genes. An inherent assumption in the use of housekeeping genes is that expression of the genes remains constant in the cells or
Autor:
Keith John Page, Dan W. Harmer, Robert A. Coleman, Sandra J. Williams, Kenneth Lyle Clark, Peter W. Munday, Richard Jon Davis, Thomas J. Evans, Joanna Picot, Gabriela J. Dos Santos Cruz, Robert L G Sheldrick
Publikováno v:
American journal of respiratory cell and molecular biology. 31(3)
The physiological role of the duodenal peptide secretin is as a potent stimulant of electrolyte and water movement in pancreatic and biliary epithelium, via activation of G protein-coupled secretin receptors (hSCTR). However, the distribution and pot
Publikováno v:
FEBS Letters. (1-2):107-110
ACE 2, a novel homologue of angiotensin converting enzyme, has recently been identified. This study used QRT-PCR to quantitatively map the transcriptional expression profile of ACE 2 (and the two isoforms of ACE) in 72 human tissues. While confirming