Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Dan Todd"'
Autor:
Maria Suprun, Daniel P. Dickstein, Xiangyu Peng, Kunal Malik, Benjamin Ungar, Emma Guttman-Yassky, Tord Labuda, Dan Todd, Mayte Suárez-Fariñas, Margeaux Oliva, Yeriel Estrada, Robert Bissonnette, Hui Xu
Publikováno v:
Journal of Allergy and Clinical Immunology.
Atopic dermatitis (AD) presents a large unmet need for treatments with better safety and efficacy. To facilitate development of topical therapeutics, we need an efficient model for assessing different formulations and concentrations. The "plaque mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21938ad9decf05cf140ec6399ce9967
Autor:
Harrison, Dan Todd
With the continuing rise of globalization, organizations face a variety of unique and complex challenges which require significant changes. One of the greatest challenges is the need to develop leaders with higher levels of global competence. Despite
Externí odkaz:
http://pqdtopen.proquest.com/#viewpdf?dispub=10134348
Autor:
Pat Wheelan, Dan Todd, Rob Ferris, Matt Tallant, Zhiping Xiong, Jung Ho Jun, Wieslaw M. Kazmierski, Maosheng Duan, Mark P. Edelstein
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6381-6385
A novel series of cyclic urea-based CCR5 antagonists was designed aiming to resolve instability issue in the fasted simulated intestinal fluid (FSIF) associated with the acyclic urea moiety in 1. This class of CCR5 compounds demonstrated high antivir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fa2166cbea9163ef4d6cea60e23b80
https://doi.org/10.1016/j.bmcl.2011.08.096
https://doi.org/10.1016/j.bmcl.2011.08.096
Autor:
Harry B. Marr, Kevin P. Madauss, Jonathan Y. Bass, Shawn P. Williams, Dan Todd, Paul Kenneth Spearing, Adwoa Akwabi-Ameyaw, Lihong Chen, Robert B. McFadyen, Justin A. Caravella, Derek J. Parks, Frank Navas, David N. Deaton, Katrina L. Creech, G. Bruce Wisely, Richard Dana Caldwell, Aaron B. Miller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4733-4739
Two series of conformationally constrained analogs of the FXR agonist GW 4064 1 were prepared. Replacement of the metabolically labile stilbene with either benzothiophene or naphthalene rings led to the identification of potent full agonists 2a and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537fc0c9b0822e4038f1ffd07428e5e6
https://doi.org/10.1016/j.bmcl.2009.06.062
https://doi.org/10.1016/j.bmcl.2009.06.062
Autor:
Justin A. Caravella, David N. Deaton, Katrina L. Creech, G. Bruce Wisely, Jonathan Y. Bass, Lihong Chen, Harry B. Marr, Robert B. McFadyen, Shawn P. Williams, Richard Dana Caldwell, Kevin P. Madauss, Aaron B. Miller, Derek J. Parks, Dan Todd
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2969-2973
Starting from the known FXR agonist GW 4064 1a, a series of alternately 3,5-substituted isoxazoles was prepared. Several of these analogs were potent full FXR agonists. A subset of this series, with a tether between the isoxazole ring and the 3-posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecaaf14e70189436e51664e2f641b1ca
https://doi.org/10.1016/j.bmcl.2009.04.047
https://doi.org/10.1016/j.bmcl.2009.04.047
Autor:
Lihong Chen, Jonathan Y. Bass, David N. Deaton, Aaron B. Miller, Justin A. Caravella, Istvan Kaldor, Robert B. McFadyen, Stacey A. Jones, Dan Todd, Paul Kenneth Spearing, Kevin P. Madauss, Adwoa Akwabi-Ameyaw, Derek J. Parks, Richard Dana Caldwell, Frank Navas, Yaping Liu, Katrina L. Creech, G. Bruce Wisely, Harry B. Marr, Shawn P. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4339-4343
Starting from the known FXR agonist GW 4064 1a, a series of stilbene replacements were prepared. The 6-substituted 1-naphthoic acid 1b was an equipotent FXR agonist with improved developability parameters relative to 1a. Analog 1b also reduced the se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519480e527d445babf5d509d5d05a857
https://doi.org/10.1016/j.bmcl.2008.06.073
https://doi.org/10.1016/j.bmcl.2008.06.073
Autor:
John W. Seal, Dan Todd, Banka Anna L, Luz H. Carballo, Zhiping Xiong, Lisa L. Stroup, Amanda Mathis, Zhi Hong, Jeffery J. Pouliot, Pek Yoke Chong, Michael Youngman, Robert Hamatake, Daniel J. Price, Jing Fang, Katrina L. Creech, Andrew Spaltenstein, John G. Catalano, Christopher Don Roberts, J. Brad Shotwell, Andrew J. Peat, Vincent W.-F. Tai, John F. Miller, Sylvia Furst, Huichang Zhang
Publikováno v:
Journal of medicinal chemistry. 57(5)
We describe the preclinical development and in vivo efficacy of a novel chemical series that inhibits hepatitis C virus replication via direct interaction with the viral nonstructural protein 4B (NS4B). Significant potency improvements were realized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285906aed0c97040c403cf0f0f1d3664
https://pubmed.ncbi.nlm.nih.gov/23544424
https://pubmed.ncbi.nlm.nih.gov/23544424
Autor:
Dan Todd, Benjamin Ungar, M. Suprun, Margeaux Oliva, Emma Guttman-Yassky, Tord Labuda, Robert Bissonnette, M. Suarez-Farinas
Publikováno v:
Journal of Investigative Dermatology. 136:S96
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edbeb91866ca64e9a119ee507afdc53d
https://doi.org/10.1016/j.jid.2016.02.582
https://doi.org/10.1016/j.jid.2016.02.582
Autor:
Mark P. Edelstein, Pat Wheelan, Rob Ferris, Matt Tallant, Jung Ho Jun, Maosheng Duan, Wieslaw M. Kazmierski, Zhiping Xiong, Dan Todd
Publikováno v:
ChemInform. 43
Design and practical syntheses of a novel class of cyclic urea-based CCR5-antagonists demonstrating high antiviral activities against HIV-1 infection in both HOS and PBL assays are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f9a0fb57b02781762ddefca6a5c8e28
https://doi.org/10.1002/chin.201209148
https://doi.org/10.1002/chin.201209148
Autor:
Aaron B. Miller, Harry B. Marr, Katrina L. Creech, G. Bruce Wisely, Shawn P. Williams, Adwoa Akwabi-Ameyaw, Lihong Chen, David N. Deaton, Justin A. Caravella, Paul Kenneth Spearing, Kevin P. Madauss, Derek J. Parks, Frank Navas, Dan Todd
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(20)
To further explore the optimum placement of the acid moiety in conformationally constrained analogs of GW 4064 1a, a series of stilbene replacements were prepared. The benzothiophene 1f and the indole 1g display the optimal orientation of the carboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f939259f5c374490a071b94fee47ab3
https://pubmed.ncbi.nlm.nih.gov/21890356
https://pubmed.ncbi.nlm.nih.gov/21890356