Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Dan Spiegelman"'
Autor:
Eric Yu, Lynne Krohn, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Zalak Shah, Ruth Chia, Isabelle Arnulf, Michele T. M. Hu, Jacques Y. Montplaisir, Jean‐François Gagnon, Alex Desautels, Yves Dauvilliers, Gian Luigi Gigli, Mariarosaria Valente, Francesco Janes, Andrea Bernardini, Birgit Högl, Ambra Stefani, Abubaker Ibrahim, Anna Heidbreder, Karel Sonka, Petr Dusek, David Kemlink, Wolfgang Oertel, Annette Janzen, Giuseppe Plazzi, Elena Antelmi, Michela Figorilli, Monica Puligheddu, Brit Mollenhauer, Claudia Trenkwalder, Friederike Sixel‐Döring, Valérie Cochen De Cock, Luigi Ferini‐Strambi, Femke Dijkstra, Mineke Viaene, Beatriz Abril, Bradley F. Boeve, Guy A. Rouleau, Ronald B. Postuma, The International LBD Genomics Consortium, Sonja W. Scholz, Ziv Gan‐Or
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 9, Pp 1682-1687 (2023)
Abstract Synucleinopathies‐related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HL
Externí odkaz:
https://doaj.org/article/07b906c4b8104604a171951f2e8d5b33
Autor:
Paria Alipour, Konstantin Senkevich, Jay P. Ross, Dan Spiegelman, Despoina Manousaki, Patrick A. Dion, Guy A. Rouleau
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-7 (2022)
Abstract Background Epidemiological studies have reported an association between amyotrophic lateral sclerosis (ALS) and different autoimmune disorders. This study aims to explore the causal relationship between autoimmune disorders and ALS using Men
Externí odkaz:
https://doaj.org/article/b1f43af7833e4a98946c077590106e80
Autor:
Wejdan M. Alenezi, Caitlin T. Fierheller, Corinne Serruya, Timothée Revil, Kathleen K. Oros, Deepak N. Subramanian, Jeffrey Bruce, Dan Spiegelman, Trevor Pugh, Ian G. Campbell, Anne-Marie Mes-Masson, Diane Provencher, William D. Foulkes, Zaki El Haffaf, Guy Rouleau, Luigi Bouchard, Celia M. T. Greenwood, Jiannis Ragoussis, Patricia N. Tonin
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Not all familial ovarian cancer (OC) cases are explained by pathogenic germline variants in known risk genes. A candidate gene approach involving DNA repair pathway genes was applied to identify rare recurring pathogenic variants in familial OC cases
Externí odkaz:
https://doaj.org/article/05d239ab593d4e42b75d51380a913fb1
Autor:
Eric Yu, Aditya Ambati, Maren Stolp Andersen, Lynne Krohn, Mehrdad A. Estiar, Prabhjyot Saini, Konstantin Senkevich, Yuri L. Sosero, Ashwin Ashok Kumar Sreelatha, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Mathias Toft, Marte K. Viken, Manu Sharma, Cornelis Blauwendraat, Lasse Pihlstrøm, Emmanuel Mignot, Ziv Gan-Or
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
Abstract We fine mapped the leukocyte antigen (HLA) region in 13,770 Parkinson’s disease (PD) patients, 20,214 proxy-cases, and 490,861 controls of European origin. Four HLA types were associated with PD after correction for multiple comparisons, H
Externí odkaz:
https://doaj.org/article/f4f24fcd8c2b4d28bc704742820e3662
Autor:
Paul Sondel, Alexander Rakhmilevich, Anna Hoefges, Mildred Felder, Zachary Morris, Amy Erbe, Arika Feils, Luke Zangl, Ravi Patel, Jacquelyn Hank, Dan Spiegelman, Alexander Pieper, Sritha Moram
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/ba7ea0b6a9b349449d5ef3b343985367
Autor:
Calwing Liao, Alexandre D. Laporte, Dan Spiegelman, Fulya Akçimen, Ridha Joober, Patrick A. Dion, Guy A. Rouleau
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
A recent GWAS reported 12 genetic loci for attention deficit/hyperactivity disorder (ADHD). Here, Liao et al. perform transcriptomic imputation using these data and 12 brain-relevant tissues from GTEx and CMC to identify 9 genes associated with ADHD
Externí odkaz:
https://doaj.org/article/98989c48e5614c72b3a29f0f4c4ddced
Autor:
Wejdan M. Alenezi, Larissa Milano, Caitlin T. Fierheller, Corinne Serruya, Timothée Revil, Kathleen K. Oros, Supriya Behl, Suzanna L. Arcand, Porangana Nayar, Dan Spiegelman, Simon Gravel, Anne-Marie Mes-Masson, Diane Provencher, William D. Foulkes, Zaki El Haffaf, Guy Rouleau, Luigi Bouchard, Celia M. T. Greenwood, Jean-Yves Masson, Jiannis Ragoussis, Patricia N. Tonin
Publikováno v:
Cancers, Vol 14, Iss 9, p 2251 (2022)
To identify candidate variants in RAD51C and RAD51D ovarian cancer (OC) predisposing genes by investigating French Canadians (FC) exhibiting unique genetic architecture. Candidates were identified by whole exome sequencing analysis of 17 OC families
Externí odkaz:
https://doaj.org/article/9185e22183a449558ad9f56120c65ec5
Autor:
Calwing Liao, Faezeh Sarayloo, Veikko Vuokila, Daniel Rochefort, Fulya Akçimen, Simone Diamond, Gabrielle Houle, Alexandre D. Laporte, Dan Spiegelman, Qin He, Hélène Catoire, Patrick A. Dion, Guy A. Rouleau
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Objective: Essential tremor (ET) is a common movement disorder that has a high heritability. A number of genetic studies have associated different genes and loci with ET, but few have investigated the biology of any of these genes. STK32B was signifi
Externí odkaz:
https://doaj.org/article/1b7dca9c79064eee9686d420cea20d75
Autor:
Mehrdad A. Estiar, Etienne Leveille, Dan Spiegelman, Nicolas Dupre, Jean-François Trempe, Guy A. Rouleau, Ziv Gan‐Or
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 3, Pp n/a-n/a (2020)
Abstract Background Hereditary spastic paraplegias (HSP) are neurodegenerative disorders characterized by lower limb spasticity and weakness, with or without additional symptoms. Mutations in ATP13A2, known to cause Kufor–Rakeb syndrome (KRS), have
Externí odkaz:
https://doaj.org/article/11cf0d4baf34423992a35dc993d9af9a
Autor:
Jaber Lyahyai, Bouchra Ouled Amar Bencheikh, Siham C. Elalaoui, Maria Mansouri, Lamia Boualla, Alexandre DIonne-Laporte, Dan Spiegelman, Patrick A. Dion, Patrick Cossette, Guy A. Rouleau, Abdelaziz Sefiani
Publikováno v:
BMC Pediatrics, Vol 18, Iss 1, Pp 1-4 (2018)
Abstract Background Epilepsy regroups a common and diverse set of chronic neurological disorders that are characterized by spontaneous, unprovoked, and recurrent epileptic seizures. Epilepsies have a highly heterogeneous background with a strong gene
Externí odkaz:
https://doaj.org/article/f733086834174ca782859d8ca61c842e