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Abstract 1131: Uncovering oncogenic KRAS allele specific phenotypes using an isogenic MEF cell line system

Autor: Leslie Garvey, Matthew Holderfield, Andrew Waters, Nicole Fer, Brian J. Smith, Xiaolin Wu, Kanika Sharma, William E. Burgan, Dwight V. Nissley, Katie Powell, Rachel Bagni, Robert L. Stephens, Dan Soppet

Publikováno v: Cancer Research. 76:1131-1131

The RAS Initiative at the Frederick National Laboratory has generated an isogenic mouse embryonic fibroblast (MEFs) cell line panel containing single transgene alleles using the RAS-less MEF system developed by Matthias Drosten and Mariano Barbacid (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::203c462e8e0b6e91c2762865184d3f88
https://doi.org/10.1158/1538-7445.am2016-1131

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The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells

Autor: Dan Soppet, Arnon Rosenthal, José Luis Mendoza-Ramirez, Lino Tessarollo, Enrique Escandon, Pantelis Tsoulfas, Luis F. Parada, Karoly Nikolics

Publikováno v: Neuron. 10:975-990

Members of the Trk tyrosine kinase family have recently been identified as functional receptors of the NGF family of neurotrophins. Here we show the rat trkC locus to be complex, encoding at least four distinct polypeptides. Three of the encoded poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a904a4b3f612503b1cb85d7ca9e16c48
https://doi.org/10.1016/0896-6273(93)90212-a

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Transcriptional and apoptotic responses of THP-1 cells to challenge with toxigenic, and non-toxigenic Bacillus anthracis

Autor: Dan Soppet, Karen Schlauch, Anna Popova, Taissia G. Popova, Qin Zong, Derong Liu, Serguei G. Popov, Myung Chul Chung, Christopher E. Bradburne, Charles L. Bailey

Publikováno v: BMC Immunology, Vol 9, Iss 1, p 67 (2008)
BMC Immunology

Background Bacillus anthracis secretes several virulence factors targeting different host organs and cell types during inhalational anthrax infection. The bacterial expression of a key virulence factor, lethal toxin (LeTx) is closely tied to another

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f5643eec0c4c6239d3cd40590d0d6e
http://www.biomedcentral.com/1471-2172/9/67

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Genomic-based high throughput screening identifies small molecules that differentially inhibit the antiviral and immunomodulatory effects of IFN-alpha

Autor: Chad Morris, Ricardo Cibotti, Ronald Herbst, Bo Chen, Anna Glodek, Anthony J. Coyle, Laurent P. Audoly, Juana Castaneda, Gary P. Sims, Stephen Horrigan, Derong Liu, Peter A. Kiener, Dan Soppet, Qin Zong, Brian Naiman

Publikováno v: Molecular medicine (Cambridge, Mass.). 14(7-8)

Multiple lines of evidence suggest that inhibition of Type I Interferons, including IFN-alpha, may provide a therapeutic benefit for autoimmune diseases. Using a chemical genomics approach integrated with cellular and in vivo assays, we screened a sm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a35aafe0c8bc55d11f81365bfadd5e
https://pubmed.ncbi.nlm.nih.gov/18475307

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Disrupted cortical map and absence of cortical barrels in growth-associated protein (GAP)-43 knockout mice

Autor: Donna L. Maier, Lino Tessarollo, Karina F. Meiri, James S. McCasland, Stacy L. Donovan, Dan Soppet, Shyamala Mani

There is strong evidence that growth-associated protein (GAP-43), a protein found only in the nervous system, regulates the response of neurons to axonal guidance signals. However, its role in complex spatial patterning in cerebral cortex has not bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683d4f2cca0845f479d954ad623ccb8f
https://europepmc.org/articles/PMC17794/

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Regulation of neurotrophin receptor expression during embryonic and postnatal development

Autor: Enrique Escandon, Luis F. Parada, José Luis Mendoza-Ramirez, Arnon Rosenthal, Christopher E. Henderson, Dan Soppet, Louis E. Burton, Karoly Nikolics, Eva Szonyi

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 14(4)

Members of the NGF family of proteins act as neurotrophic agents for defined populations of peripheral and central neurons during embryonic and postnatal development. We have studied the presence of receptors for brain-derived neurotrophic factor (BD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1b811ee8d18c3e2b3867034ac483a1
https://pubmed.ncbi.nlm.nih.gov/8158256

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Distribution of trkB tyrosine kinase immunoreactivity in the rat central nervous system

Autor: Robert A. Rush, Xin-Fu Zhou, Dan Soppet, Luis F. Parada

Publikováno v: Brain research. 622(1-2)

Recent evidence suggests that trkB tyrosine kinase is a high affinity receptor for brain-derived neurotrophic factor (BDNF). BDNF can act as a survival factor for several neuronal subgroups and its mRNA is distributed widely throughout the central ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e34ac6b2d5d48b7d579e2742e5b756d
https://pubmed.ncbi.nlm.nih.gov/8242385

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The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

Autor: Brian R. Stanton, Louis E. Burton, Tony Hunter, Dan Soppet, Enrique Escandon, Luis F. Parade, Karoly Nikolics, Janet Blair, Johnne Maragos, David S. Middlemas, David R. Kaplan, Susan W. Raid

Publikováno v: Cell. 65(5)

Neurotrophic factors are essential for neuronal survival and function. Recent data have demonstrated that the product of the tyrosine kinase trk proto-oncogene binds NGF and is a component of the high affinity NGF receptor. Analysis of the trkB gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9906a3c303fa7afb79fbf64040a6bd
https://pubmed.ncbi.nlm.nih.gov/1645620

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Genomic-based high throughput screening and identification of small molecule inhibitors targeting IFN α signaling pathways (131.17)

Autor: Bo Chen, Ricardo Cibotti, Qin Zong, Chad Morris, Juana Castaneda, Brian Naiman, Derong Liu, Anna Glodek, Dan Soppet, Steve Horrigan, Peter Kiener, Anthony Coyle, Laurent Audoly

Publikováno v: The Journal of Immunology. 178:S240-S240

Multiple lines of evidence suggest that inhibition of Type I Interferons (IFNs), including IFN(, may provide a therapeutic benefit in treating a number of autoimmune diseases such as Systemic Lupus Erythematosus (SLE). Herein, we describe the generat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5713c829a0f56ac6bcb0682cd0014e56
https://doi.org/10.4049/jimmunol.178.supp.131.17

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