Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Dan S. Luciani"'
Autor:
Alex Z. Kadhim, Ben Vanderkruk, Samantha Mar, Meixia Dan, Katarina Zosel, Eric E. Xu, Rachel J. Spencer, Shugo Sasaki, Xuanjin Cheng, Shannon L. J. Sproul, Thilo Speckmann, Cuilan Nian, Robyn Cullen, Rocky Shi, Dan S. Luciani, Bradford G. Hoffman, Stefan Taubert, Francis C. Lynn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mediator, a co-regulator complex required for RNA Polymerase II activity, interacts with tissue-specific transcription factors to regulate development and maintain homeostasis. We observe reduced Mediator subunit MED15 expression in endocrin
Externí odkaz:
https://doaj.org/article/a99eab33e6ef46a1bcc1575a5001e336
Autor:
Shugo Sasaki, Cuilan Nian, Eric E. Xu, Daniel J. Pasula, Helena Winata, Sanya Grover, Dan S. Luciani, Francis C. Lynn
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107311- (2023)
Summary: Restoring functional β cell mass is a potential therapy for those with diabetes. However, the pathways regulating β cell mass are not fully understood. Previously, we demonstrated that Sox4 is required for β cell proliferation during pred
Externí odkaz:
https://doaj.org/article/4b4e9944c9d2462ca5dbfa7c24f73e0c
Autor:
Søs Skovsø, Evgeniy Panzhinskiy, Jelena Kolic, Haoning Howard Cen, Derek A. Dionne, Xiao-Qing Dai, Rohit B. Sharma, Lynda Elghazi, Cara E. Ellis, Katharine Faulkner, Stephanie A. M. Marcil, Peter Overby, Nilou Noursadeghi, Daria Hutchinson, Xiaoke Hu, Hong Li, Honey Modi, Jennifer S. Wildi, J. Diego Botezelli, Hye Lim Noh, Sujin Suk, Brian Gablaski, Austin Bautista, Ryekjang Kim, Corentin Cras-Méneur, Stephane Flibotte, Sunita Sinha, Dan S. Luciani, Corey Nislow, Elizabeth J. Rideout, Eric N. Cytrynbaum, Jason K. Kim, Ernesto Bernal-Mizrachi, Laura C. Alonso, Patrick E. MacDonald, James D. Johnson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Insulin receptor protein is present in pancreatic β-cells, but the consequences of β-cell insulin resistance are incompletely understood. Here the authors use a combination of mouse studies and mathematical modelling to show that loss of beta-cell
Externí odkaz:
https://doaj.org/article/34fcff15f65143fa8ca0bab84b4cd93e
Autor:
Bernard Kan, Christina Michalski, Helen Fu, Hilda H. T. Au, Kelsey Lee, Elizabeth A. Marchant, Maye F. Cheng, Emily Anderson-Baucum, Michal Aharoni-Simon, Peter Tilley, Raghavendra G. Mirmira, Colin J. Ross, Dan S. Luciani, Eric Jan, Pascal M. Lavoie
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Little is known about developmental set points of immune responses, especially in humans. Here the authors show that the metabolic state of monocytes isolated from prematurely born infants underlies attenuated responsiveness to fungal infection via s
Externí odkaz:
https://doaj.org/article/08e85291ad4f44b1ab3852a20f070f42
Autor:
Aline Daniel, Cassandra L. McDonald, Brad G. Hoffman, Nina Maeshima, Dan S. Luciani, Ben Vanderkruk, Daniel J. Pasula, Meilin An, Priya Suresh
Publikováno v:
Diabetologia. 66:1097-1115
Aims/hypothesis Beta cells control glucose homeostasis via regulated production and secretion of insulin. This function arises from a highly specialised gene expression programme that is established during development and then sustained, with limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a743a6f3475ec9f8172e2c49f228f996
https://doi.org/10.1007/s00125-023-05896-6
https://doi.org/10.1007/s00125-023-05896-6
Autor:
Shugo Sasaki, Cuilan Nian, Eric E. Xu, Daniel J. Pasula, Helena Winata, Sanya Grover, Dan S. Luciani, Francis C. Lynn
ObjectiveDiabetes onset is accompanied with β-cell deficiency, and thus restoring functional β-cell mass is a promising therapy for those with diabetes. However, the regulatory mechanisms controlling β-cell mass are not fully understood. Previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb725225f32dfb659cbd0f108cd8ac6
https://doi.org/10.1101/2022.12.23.521810
https://doi.org/10.1101/2022.12.23.521810
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
ER stress and apoptosis contribute to the loss of pancreatic β-cells under pro-diabetic conditions of glucolipotoxicity. Although activation of canonical intrinsic apoptosis is known to require pro-apoptotic Bcl-2 family proteins Bax and Bak, their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0f868b10d1c2f18ac989ba9551baff
http://link.springer.com/article/10.1038/s41598-020-67755-3
http://link.springer.com/article/10.1038/s41598-020-67755-3
Publikováno v:
Am J Physiol Endocrinol Metab
Mitochondrial network morphology and dynamics are inextricably linked to cellular metabolism and health, and live-cell imaging of mitochondria can therefore provide vital insights into both physiology and pathophysiology. As a notable example, mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3ef37afc17dac03adc1bee8199bb82
https://doi.org/10.1152/ajpendo.00457.2019
https://doi.org/10.1152/ajpendo.00457.2019
Autor:
Daniel J. Pasula, Ahsen Chaudhry, Rocky Shi, Yuanjie Zou, Dan S. Luciani, Alexis Z.L. Shih, Ben Vanderkruk, Brad Hoffman
In the progression of diabetes, pancreatic islet β-cells respond to increased metabolic demand with functional compensation, followed by pathogenic decompensation of mitochondria-dependent insulin secretion. It is not clear what mechanisms drive, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58daa21e10dd2c046b87e514db5e3a00
https://doi.org/10.1101/2021.10.25.465491
https://doi.org/10.1101/2021.10.25.465491
Publikováno v:
Diabetes. 70
Proinsulin (PI) is processed to mature insulin by prohormone convertases 1/3 (Pcsk1) and 2 (Pcsk2). In individuals with T1D and T2D, there is an increase in the circulating PI:insulin ratio. We hypothesized that β-cell Pcsk1 and Pcsk2 deletion would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2ee22ad257209ac90a11fe6e642166b
https://doi.org/10.2337/db21-123-or
https://doi.org/10.2337/db21-123-or