Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Dan S, Tawfik"'
Autor:
Kaitlyn Tsai, Vanja Stojković, Lianet Noda-Garcia, Iris D Young, Alexander G Myasnikov, Jordan Kleinman, Ali Palla, Stephen N Floor, Adam Frost, James S Fraser, Dan S Tawfik, Danica Galonić Fujimori
Publikováno v:
eLife, Vol 11 (2022)
Alteration of antibiotic binding sites through modification of ribosomal RNA (rRNA) is a common form of resistance to ribosome-targeting antibiotics. The rRNA-modifying enzyme Cfr methylates an adenosine nucleotide within the peptidyl transferase cen
Externí odkaz:
https://doaj.org/article/24316c8437014466b4b990837558a00d
Autor:
Liam M Longo, Jagoda Jabłońska, Pratik Vyas, Manil Kanade, Rachel Kolodny, Nir Ben-Tal, Dan S Tawfik
Publikováno v:
eLife, Vol 9 (2020)
This article is dedicated to the memory of Michael G. Rossmann. Dating back to the last universal common ancestor, P-loop NTPases and Rossmanns comprise the most ubiquitous and diverse enzyme lineages. Despite similarities in their overall architectu
Externí odkaz:
https://doaj.org/article/78e631a8267442aaa3cc5e6804dd8ea3
Autor:
Saurav Mallik, Dan S Tawfik
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1008145 (2020)
Oligomeric proteins are central to life. Duplication and divergence of their genes is a key evolutionary driver, also because duplications can yield very different outcomes. Given a homomeric ancestor, duplication can yield two paralogs that form two
Externí odkaz:
https://doaj.org/article/2d1a29cf232347b5bb8475b9200f56c6
Autor:
Renee Otten, Lin Liu, Lillian R. Kenner, Michael W. Clarkson, David Mavor, Dan S. Tawfik, Dorothee Kern, James S. Fraser
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
A key challenge in the field of protein design and evolution is to understand the mechanisms by which directed evolution is improving enzymes. Here the authors combine different biophysical methods and give mechanistic insights into how directed evol
Externí odkaz:
https://doaj.org/article/92e5d2150eec485a8a3eef20778b77f0
Publikováno v:
Journal of the American Chemical Society.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3fffaf84d5cf8c59f14ad2964c2b27b
https://doi.org/10.1021/jacs.2c08636
https://doi.org/10.1021/jacs.2c08636
Autor:
Daniella Schatz, Ron Rotkopf, Flora Vincent, Adva Shemi, Viviana Farstey, Assaf Vardi, Shifra Ben-Dor, Uria Alcolombri, Dan S. Tawfik, Miguel J. Frada
Publikováno v:
Nature Microbiology. 6:1357-1366
Phytoplankton are key components of the oceanic carbon and sulfur cycles1. During bloom events, some species can emit large amounts of the organosulfur volatile dimethyl sulfide (DMS) into the ocean and consequently the atmosphere, where it can modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969e65eececcef44521224a4132918e0
https://doi.org/10.1038/s41564-021-00971-3
https://doi.org/10.1038/s41564-021-00971-3
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 57:1-15
Among the enzyme lineages that undoubtedly emerged prior to the last universal common ancestor is the so-called HUP, which includes Class I aminoacyl tRNA synthetases (AARSs) as well as enzymes mediating NAD, FAD, and CoA biosynthesis. Here, we provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c062f0d2fea4e5ae0adb05369aa94ff
https://doi.org/10.1080/10409238.2021.1957764
https://doi.org/10.1080/10409238.2021.1957764
Publikováno v:
Protein Science. 31
Superoxide dismutases (SODs) are critical metalloenzymes mitigating the damages of the modern oxygenated world. However, the emergence of one family of SODs, the Fe/Mn SOD, has been recurrently proposed to predate the great oxygenation event (GOE). T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f80f6ddeac31eaabf1ee36669e428e
https://doi.org/10.1002/pro.4423
https://doi.org/10.1002/pro.4423
Autor:
Dragana Despotović, Einav Aharon, Olena Trofimyuk, Artem Dubovetskyi, Kesava Phaneendra Cherukuri, Yacov Ashani, Or Eliason, Martin Sperfeld, Haim Leader, Andrea Castelli, Laura Fumagalli, Alon Savidor, Yishai Levin, Liam M. Longo, Einat Segev, Dan S. Tawfik
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Anthropogenic organophosphorus compounds (AOPCs), such as phosphotriesters, are used extensively as plasticizers, flame retardants, nerve agents, and pesticides. To date, only a handful of soil bacteria bearing a phosphotriesterase (PTE), the key enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dea64629062f425106cb4a391722fe3
https://doi.org/10.1073/pnas.2203604119
https://doi.org/10.1073/pnas.2203604119
Autor:
Elad Noor, Avi I. Flamholz, Vijay Jayaraman, Brian L. Ross, Yair Cohen, Wayne M. Patrick, Ita Gruic‐Sovulj, Dan S. Tawfik
Enzymes are well known for their catalytic abilities, some even reaching "catalytic perfection" in the sense that the reaction they catalyze has reached the physical bound of the diffusion rate. However, our growing understanding of enzyme superfamil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144152ffc84fed9bff9f8ec00129e5a2
https://resolver.caltech.edu/CaltechAUTHORS:20220714-369203000
https://resolver.caltech.edu/CaltechAUTHORS:20220714-369203000
