Trafficking, localization and degradation of the Na+,HCO3 − co-transporter NBCn1 in kidney and breast epithelial cells

Autor: Christina Wilkens Olesen, Jens Vogensen, Ida Axholm, Marc Severin, Julie Schnipper, Isabella Skandorff Pedersen, Jakob Hjorth von Stemann, Jacob Morville Schrøder, Dan Ploug Christensen, Stine Falsig Pedersen

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)

Abstract The Na+;HCO3− co-transporter NBCn1 (SLC4A7) is a major regulator of intracellular pH yet its trafficking and turnover are essentially unstudied. Here, we used MDCK-II and MCF-7 cells to investigate these processes in epithelial cells. GFP-

Externí odkaz: https://doaj.org/article/88514809b5334da8bc2989f2186a830f

6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice

Autor: Kassem Makki, Harald Brolin, Natalia Petersen, Marcus Henricsson, Dan Ploug Christensen, Muhammad Tanweer Khan, Annika Wahlström, Per-Olof Bergh, Valentina Tremaroli, Kristina Schoonjans, Hanns-Ulrich Marschall, Fredrik Bäckhed

Publikováno v: Gut, 72 (2)
Makki, K, Brolin, H, Petersen, N, Henricsson, M, Christensen, D P, Khan, M T, Wahlström, A, Bergh, P-O, Tremaroli, V, Schoonjans, K, Marschall, H-U & Bäckhed, F 2023, ' 6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice ', Gut, vol. 72, pp. 314-324 . https://doi.org/10.1136/gutjnl-2021-326541

Objective Dietary fibres are essential for maintaining microbial diversity and the gut microbiota can modulate host physiology by metabolising the fibres. Here, we investigated whether the soluble dietary fibre oligofructose improves host metabolism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0bf96e61639223e36cacfb3ff99cc01
https://hdl.handle.net/20.500.11850/553802

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Autor: Seth McGonigle, Susanne Mandrup, Olivia Sveidahl Johansen, Laia Reverte-Salisa, Rudolf Zechner, Lasse K. Markussen, Thomas Nielsen, Eline N. Kuipers, Andreas Kjaer, Maria Razzoli, Alexander Pfeifer, Jakob Bondo Hansen, Cheryl Cero, Alessandro Bartolomucci, James G. Granneman, Brice Emanuelli, Raymond E. Soccio, Morten Lundh, Thue Walter Schwartz, Søren Nielsen, Wenfei Sun, Dan Ploug Christensen, Hua Dong, Christa Broholm, Thorsten Gnad, Nienke Willemsen, Camilla Scheele, William Orchard, Oksana Dmytriyeva, Iuliia Karavaeva, Patrick C.N. Rensen, Marie S. Isidor, Sander Kooijman, Niels Grarup, Mikkel Frost, Cecilie Mørch Hallgren, Davide Calebiro, Tao Ma, Naja Z. Jespersen, M. Madan Babu, Mikael Rydén, Shannon L. O'Brien, Carsten H. Nielsen, Renate Schreiber, Zachary Gerhart-Hines, Jacob B. Hansen, Jonas T. Treebak, Yachen Shen, Torben Hansen, Oluf Pedersen, Elahu G. Sustarsic

Publikováno v: Sveidahl Johansen, O, Ma, T, Hansen, J B, Markussen, L K, Schreiber, R, Reverte-Salisa, L, Dong, H, Christensen, D P, Sun, W, Gnad, T, Karavaeva, I, Nielsen, T S, Kooijman, S, Cero, C, Dmytriyeva, O, Shen, Y, Razzoli, M, O'Brien, S L, Kuipers, E N, Nielsen, C H, Orchard, W, Willemsen, N, Jespersen, N Z, Lundh, M, Sustarsic, E G, Hallgren, C M, Frost, M, McGonigle, S, Isidor, M S, Broholm, C, Pedersen, O, Hansen, J B, Grarup, N, Hansen, T, Kjær, A, Granneman, J G, Babu, M M, Calebiro, D, Nielsen, S, Rydén, M, Soccio, R, Rensen, P C N, Treebak, J T, Schwartz, T W, Emanuelli, B, Bartolomucci, A, Pfeifer, A, Zechner, R, Scheele, C, Mandrup, S & Gerhart-Hines, Z 2021, ' Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis ', Cell, vol. 184, no. 13, pp. 3502-3518 . https://doi.org/10.1016/j.cell.2021.04.037
Cell
Sveidahl Johansen, O, Ma, T, Hansen, J B, Markussen, L K, Schreiber, R, Reverte-Salisa, L, Dong, H, Christensen, D P, Sun, W, Gnad, T, Karavaeva, I, Nielsen, T S, Kooijman, S, Cero, C, Dmytriyeva, O, Shen, Y, Razzoli, M, O'Brien, S L, Kuipers, E N, Nielsen, C H, Orchard, W, Willemsen, N, Jespersen, N Z, Lundh, M, Sustarsic, E G, Hallgren, C M, Frost, M, McGonigle, S, Isidor, M S, Broholm, C, Pedersen, O, Hansen, J B, Grarup, N, Hansen, T, Kjær, A, Granneman, J G, Babu, M M, Calebiro, D, Nielsen, S, Rydén, M, Soccio, R, Rensen, P C N, Treebak, J T, Schwartz, T W, Emanuelli, B, Bartolomucci, A, Pfeifer, A, Zechner, R, Scheele, C, Mandrup, S & Gerhart-Hines, Z 2021, ' Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis ', Cell, vol. 184, no. 13, pp. 3502-3518 + . https://doi.org/10.1016/j.cell.2021.04.037
Cell, 184 (13)
Cell, 184(13), 3502-3518.e33. CELL PRESS
Nat Rev Endocrinol

Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity, which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein-coupled receptors (GPCRs). Here, we uncover an alternate paradigm of GP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fad4327df6593d39587aa7ce062641
https://findresearcher.sdu.dk:8443/ws/files/184106202/PIIS0092867421005729.pdf

The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets

Autor: Dan Ploug Christensen, Jakob Bondo Hansen, Thomas Mandrup-Poulsen, Seyed Mojtaba Ghiasi, Björn Tyrberg

Publikováno v: International Journal of Molecular Sciences
Ghiasi, S M, Hansen, J B, Christensen, D P, Tyrberg, B & Mandrup-Poulsen, T 2020, ' The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets ', International journal of molecular sciences, vol. 21, no. 12 . https://doi.org/10.3390/ijms21124311
International Journal of Molecular Sciences, Vol 21, Iss 4311, p 4311 (2020)
Ghiasi, S M, Hansen, J B, Christensen, D P, Tyrberg, B & Mandrup-Poulsen, T 2020, ' The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets ', International Journal of Molecular Sciences (Online), vol. 21, no. 12, 4311 . https://doi.org/10.3390/ijms21124311
Volume 21
Issue 12

Background: Intercellular communication mediated by cationic fluxes through the Connexin family of gap junctions regulates glucose-stimulated insulin secretion and beta cell defense against inflammatory stress. Rotigaptide (RG, ZP123) is a peptide an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6abcd30245c0405a97103ff0148386
http://europepmc.org/articles/PMC7352593

An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection

Autor: Florence F. Wagner, Deepika Walpita, Jennifer P. Gale, Noel G. Morgan, Bennett C. Meier, Shrikanta Chattopadhyay, Thomas Mandrup-Poulsen, Tamara J. Gilbert, Amedeo Vetere, Jacob M. Hooker, Taner Kaya, Mélanie Leroy, Sarah J. Richardson, Edward B. Holson, Yan-Ling Zhang, Morten Lundh, Stewart L. Fisher, Thomas Galbo, Patrick McCarren, Bridget K. Wagner, Dan Ploug Christensen

Publikováno v: ACS Chemical Biology. 11:363-374

Modulation of histone deacetylase (HDAC) activity has been implicated as a potential therapeutic strategy for multiple diseases. However, it has been difficult to dissect the role of individual HDACs due to a lack of selective small-molecule inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97aaaae955cd40727b4ef2db2db7d02
https://doi.org/10.1021/acschembio.5b00640