Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Dan Peer"'
Autor:
Han Gao, Sen Li, Zhengyi Lan, Da Pan, Gonna Somu Naidu, Dan Peer, Chenyi Ye, Hangrong Chen, Ming Ma, Zehua Liu, Hélder A. Santos
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Ionotropic gelation is widely used to fabricate targeting nanoparticles (NPs) with polysaccharides, leveraging their recognition by specific lectins. Despite the fabrication scheme simply involves self-assembly of differently charged compone
Externí odkaz:
https://doaj.org/article/db240f5ad56e431390053d2dae765e10
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102224- (2024)
Locked nucleic acids (LNAs) are a subtype of antisense oligonucleotides (ASOs) that are characterized by a bridge within the sugar moiety. LNAs owe their robustness to this chemical modification, which as the name suggests, locks it in one conformati
Externí odkaz:
https://doaj.org/article/b1eb482cd3314782a524ed9039825d9b
Autor:
Dor Breier, Dan Peer
Publikováno v:
Bioactive Materials, Vol 21, Iss , Pp 394-402 (2023)
Ever since its mechanism was discovered back in 2012, the CRISPR/Cas9 system have revolutionized the field of genome editing. While at first it was seen as a therapeutic tool mostly relevant for curing genetic diseases, it has been recently shown to
Externí odkaz:
https://doaj.org/article/65ca1e1eb8454a92919279e366a5d69e
Autor:
Yuval Bin Kanner, Qiu-Xu Teng, Assaf Ganoth, Dan Peer, Jing-Quan Wang, Zhe-Sheng Chen, Yossi Tsfadia
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Cancer is one of the leading causes of death worldwide, and the development of resistance to chemotherapy drugs is a major challenge in treating malignancies. In recent years, researchers have focused on understanding the mechanisms of multidrug resi
Externí odkaz:
https://doaj.org/article/40ab2f3d41d3461eaff5df8f603a74e4
Publikováno v:
HemaSphere, Vol 7, p e72049bc (2023)
Externí odkaz:
https://doaj.org/article/d6c0f02e73dd478d8285737d48ffe0c3
Autor:
Dana Tarab‐Ravski, Inbal Hazan‐Halevy, Meir Goldsmith, Lior Stotsky‐Oterin, Dor Breier, Gonna Somu Naidu, Anjaiah Aitha, Yael Diesendruck, Brandon D. Ng, Hagit Barsheshet, Tamar Berger, Iuliana Vaxman, Pia Raanani, Dan Peer
Publikováno v:
Advanced Science, Vol 10, Iss 21, Pp n/a-n/a (2023)
Abstract Multiple myeloma (MM) is a cancer of differentiated plasma cells that occurs in the bone marrow (BM). Despite the recent advancements in drug development, most patients with MM eventually relapse and the disease remains incurable. RNA therap
Externí odkaz:
https://doaj.org/article/dc700ea7385f4fe49077cd9f580bac40
Autor:
Gonna Somu Naidu, Seok‐Beom Yong, Srinivas Ramishetti, Riccardo Rampado, Preeti Sharma, Assaf Ezra, Meir Goldsmith, Inbal Hazan‐Halevy, Sushmita Chatterjee, Anjaiah Aitha, Dan Peer
Publikováno v:
Advanced Science, Vol 10, Iss 19, Pp n/a-n/a (2023)
Abstract Ionizable lipid‐based nanoparticles (LNPs) are the most advanced non‐viral drug delivery systems for RNA therapeutics and vaccines. However, cell type‐specific, extrahepatic mRNA delivery is still a major hurdle, hampering the developm
Externí odkaz:
https://doaj.org/article/8f0b4086caf74fd7a771aab230a4d877
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 12872 (2022)
Early detection of tumor cells by identifying universal Tumor Associated Antigens (TAA) can drastically change our diagnostic, theranostic and therapeutic possibilities to cure cancer. Human Telomerase Reverse Transcriptase (hTERT), a hallmark of can
Externí odkaz:
https://doaj.org/article/1a793b9c3c54453486ebd56d341cdded
Autor:
Michele Schlich, Roberto Palomba, Gabriella Costabile, Shoshy Mizrahy, Martina Pannuzzo, Dan Peer, Paolo Decuzzi
Publikováno v:
Bioengineering & Translational Medicine, Vol 6, Iss 2, Pp n/a-n/a (2021)
Abstract Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nano‐delivery system for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with increased in vivo potency brought LNPs from the labo
Externí odkaz:
https://doaj.org/article/59727285d9c041cfa4813bef3b0fc601
Autor:
Nuphar Veiga, Meir Goldsmith, Yasmin Granot, Daniel Rosenblum, Niels Dammes, Ranit Kedmi, Srinivas Ramishetti, Dan Peer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Therapeutic alteration of protein expression using modified mRNA is limited by immunogenicity and instability in vivo. Here the authors use antibody-coated lipid nanoparticles to deliver mRNA to leukocytes and drive expression of anti-inflammatory cy
Externí odkaz:
https://doaj.org/article/9f873ddd64ac44b1bc45f41c3236a99a