Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Dan P Felsenfeld"'
Autor:
Melody M H Li, Zerlina Lau, Pamela Cheung, Eduardo G Aguilar, William M Schneider, Leonia Bozzacco, Henrik Molina, Eugen Buehler, Akinori Takaoka, Charles M Rice, Dan P Felsenfeld, Margaret R MacDonald
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006145 (2017)
The host factor and interferon (IFN)-stimulated gene (ISG) product, zinc-finger antiviral protein (ZAP), inhibits a number of diverse viruses by usurping and intersecting with multiple cellular pathways. To elucidate its antiviral mechanism, we perfo
Externí odkaz:
https://doaj.org/article/a8efea74f386440099de31c0b39f4517
Autor:
Maura Galimberti, Maria R. Nucera, Vittoria D. Bocchi, Paola Conforti, Elena Vezzoli, Matteo Cereda, Camilla Maffezzini, Raffaele Iennaco, Andrea Scolz, Andrea Falqui, Chiara Cordiglieri, Martina Cremona, Ira Espuny-Camacho, Andrea Faedo, Dan P. Felsenfeld, Thomas F. Vogt, Valeria Ranzani, Chiara Zuccato, Dario Besusso, Elena Cattaneo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Huntington’s disease (HD) causes selective degeneration of striatal and cortical neurons, resulting in cell mosaicism of coexisting still functional and dysfunctional cells. The impact of non-cell autonomous mechanisms between these cellul
Externí odkaz:
https://doaj.org/article/f886204e00154c1a8e03cf3cdc9d56ff
Publikováno v:
Frontiers in Endocrinology, Vol 7 (2016)
Background: To identify novel small molecules against the TSH receptor, we developed a sensitive transcription-based luciferase high-throughput screening (HTS) system named the TSHR-Glo Assay (TSHR-Glo). Methods: This assay uses double-transfected CH
Externí odkaz:
https://doaj.org/article/bef0b0a1bb3045818facfbe2afbd2220
Autor:
Jung-Hoon Lee, Maren Thomsen, Herwin Daub, Stefan C. Steinbacher, Agnieszka Sztyler, Gabriel Thieulin-Pardo, Tobias Neudegger, Nikolay V. Plotnikov, Ravi R. Iyer, Hilary A. Wilkinson, Edith Monteagudo, Dan P. Felsenfeld, Tasir S. Haque, Michael Finley, Celia Dominguez, Thomas F. Vogt, Brinda C. Prasad
Huntington’s disease (HD) is fatal neurodegenerative disorder caused by the expansion of a CAG-repeat tract in the huntingtin (HTT) gene. Human and mouse genetics studies have demonstrated a role for DNA mismatch repair (MMR) proteins which control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183b5ff9f85869d81d144088519fcbbf
https://doi.org/10.1101/2023.05.08.539930
https://doi.org/10.1101/2023.05.08.539930
Autor:
Dan P. Felsenfeld, Benjamin K. Chen, Talia H. Swartz, Christopher F. Basler, Anthony M. Esposito, Pam Cheung, Natasha D. Durham, Tshidi Tsibane, Hongru Li
Publikováno v:
Virology. 490:6-16
Enveloped virus entry occurs when viral and cellular membranes fuse releasing particle contents into the target cell. Human immunodeficiency virus (HIV) entry occurs by cell-free virus or virus transferred between infected and uninfected cells throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6197435fafaf5aca001e26cd29e099b6
https://doi.org/10.1016/j.virol.2015.10.013
https://doi.org/10.1016/j.virol.2015.10.013
Autor:
Juan-Carlos Alvarez-Perez, Aaron Bender, Sharmila Sivendran, Andrew F. Stewart, Adolfo Garcia-Ocaña, Peng Wang, Donald K. Scott, Roberto Sanchez, Dan P. Felsenfeld, Anil Kumar, Hongtao Liu
Publikováno v:
Nature Medicine. 21:383-388
Types 1 and 2 diabetes affect some 380 million people worldwide. Both ultimately result from a deficiency of functional pancreatic insulin-producing beta cells. Beta cells proliferate in humans during a brief temporal window beginning around the time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc285a296772196107afb4469c2e6f35
https://doi.org/10.1038/nm.3820
https://doi.org/10.1038/nm.3820
Autor:
Melody M. H. Li, William M. Schneider, Leonia Bozzacco, Henrik Molina, Pam Cheung, Zerlina Lau, Dan P. Felsenfeld, Charles M. Rice, Eugen Buehler, Margaret R. MacDonald, Akinori Takaoka, Eduardo G. Aguilar
Publikováno v:
PLoS pathogens, vol 13, iss 1
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 1, p e1006145 (2017)
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 1, p e1006145 (2017)
The host factor and interferon (IFN)-stimulated gene (ISG) product, zinc-finger antiviral protein (ZAP), inhibits a number of diverse viruses by usurping and intersecting with multiple cellular pathways. To elucidate its antiviral mechanism, we perfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0606d52c74cc11d90f1729088f684d8
https://escholarship.org/uc/item/6rc5w259
https://escholarship.org/uc/item/6rc5w259
Autor:
Zerlina Lau, Veronika Redmann, Thomas J. Gardner, Keita Morohashi, Dan P. Felsenfeld, Domenico Tortorella
Publikováno v:
Toxins, Vol 6, Iss 1, Pp 33-53 (2013)
Toxins
Volume 6
Issue 1
Pages: 33-53
Toxins
Volume 6
Issue 1
Pages: 33-53
Ricin toxin, an A-B toxin from Ricinus communis, induces cell death through the inhibition of protein synthesis. The toxin binds to the cell surface via its B chain (RTB) followed by its retrograde trafficking through intracellular compartments to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fa29a5e6b0d4784ed3fad389ea7e82
http://www.mdpi.com/2072-6651/6/1/33
http://www.mdpi.com/2072-6651/6/1/33
Autor:
Jin Bai, Kenneth Wu, Inger Tappin, Zhen-Qiang Pan, Ning Zheng, Junnian Zheng, Jerard Hurwitz, Donald E. Spratt, Kevin Ching, Chan Lee, Haibin Miao, Robert A. Chong, Dan P. Felsenfeld, Yi Sun, Qing Yu, Gary S. Shaw, Roberto Sanchez
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Cullin-RING E3 ubiquitin ligases (CRL) control a myriad of biological processes by directing numerous protein substrates for proteasomal degradation. Key to CRL activity is the recruitment of the E2 ubiquitin-conjugating enzyme Cdc34 through electros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a314e314b9a427363ac4f06dbfcb678a
https://doi.org/10.1073/pnas.1601089113
https://doi.org/10.1073/pnas.1601089113
Publikováno v:
Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 7 (2016)
Frontiers in Endocrinology, Vol 7 (2016)
Background To identify novel small molecules against the TSH receptor, we developed a sensitive transcription-based luciferase high-throughput screening (HTS) system named the TSHR-Glo Assay (TSHR-Glo). Methods This assay uses double-transfected Chin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4b2998063cf3d93bf03aa685a9b161
http://europepmc.org/articles/PMC4729884
http://europepmc.org/articles/PMC4729884