Výsledky vyhledávání - "Dan O. Debrah"

Effects of relaxin on systemic arterial hemodynamics and mechanical properties in conscious rats: sex dependency and dose response

Autor: Dan O. Debrah, Kirk P. Conrad, Lee A. Danielson, Sanjeev G. Shroff

Publikováno v: Journal of Applied Physiology. 98:1013-1020

We previously showed that chronic administration of recombinant human relaxin (rhRLX; 4 microg/h) to conscious female, nonpregnant rats to reach serum levels corresponding to early to midgestation (approximately 20 ng/ml) increases cardiac output (CO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb2cd1781521a2424bdad7576630750
https://doi.org/10.1152/japplphysiol.01083.2004

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Relaxin Modifies Systemic Arterial Resistance and Compliance in Conscious, Nonpregnant Rats

Autor: Sanjeev G. Shroff, Kirk P. Conrad, Dan O. Debrah, Lee A. Danielson, Jackie Novak

Publikováno v: Endocrinology. 145:3289-3296

Relaxin emanates from the corpus luteum of the ovary and circulates during pregnancy. Because the hormone is a potent renal vasodilator and mediates the renal vasodilation and hyperfiltration of pregnancy in conscious rats, we reasoned that it might

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7a9eddadb6144b9d9402158a28b305
https://doi.org/10.1210/en.2003-1612

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Relaxin regulates vascular wall remodeling and passive mechanical properties in mice

Autor: Kirk P. Conrad, Jonathan T. McGuane, Michael S. Sacks, Sanjeev G. Shroff, Jamie Haney, Dan O. Debrah, Julianna E. Debrah

Publikováno v: Journal of applied physiology (Bethesda, Md. : 1985). 111(1)

Administration of recombinant human relaxin (rhRLX) to conscious rats increases global arterial compliance, and small renal arteries (SRA) isolated from these rats demonstrate increased passive compliance. Here we characterize relaxin-induced vascula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cacaedd635afc1fa6361e7fe10dacbdd
https://pubmed.ncbi.nlm.nih.gov/21551018

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Role of relaxin in maternal systemic and renal vascular adaptations during gestation

Autor: Julianna E. Debrah, Dan O. Debrah, Kirk P. Conrad, Sanjeev G. Shroff, J. Peter Rubin, Jonathan T. McGuane, Mark S. Segal

Publikováno v: Annals of the New York Academy of Sciences. 1160

In this paper, the hemodynamic changes of normal pregnancy are reviewed and the underlying hormonal and molecular mechanisms are discussed. Among other findings related to these phenomena, our previous work has demonstrated the importance of relaxin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323bfe3bf49c239baab336cdf3bee61a
https://pubmed.ncbi.nlm.nih.gov/19416209

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Evidence for local relaxin ligand-receptor expression and function in arteries

Autor: Sanjeev G. Shroff, Karen Hanley-Yanez, Kirk P. Conrad, Kimberly Indovina, Dan O. Debrah, Laura J. Parry, Jacqueline Novak, Laurie J. Kerchner, Julianna Matthews, Ketah D. Doty

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20(13)

Relaxin is a 6 kDa protein hormone produced by the corpus luteum and secreted into the blood during pregnancy in rodents and humans. Growing evidence indicates that circulating relaxin causes vasodilatation and increases in arterial compliance, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239f7ac760e27baa78846deaf40bef95
https://pubmed.ncbi.nlm.nih.gov/17077312

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Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats

Autor: Julianna Matthews, Jackie Novak, Dan O. Debrah, Rolando J. Ramirez, Sanjeev G. Shroff, Kirk P. Conrad

Publikováno v: Endocrinology. 147(11)

During early pregnancy, there are marked increases in cardiac output (CO) and global arterial compliance (AC), as well as decreases in systemic vascular resistance (SVR). We recently reported that administration of recombinant human relaxin to nonpre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae43ca6c31e9dc078058685ea1b6451
https://pubmed.ncbi.nlm.nih.gov/16873529

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Relaxin increases cardiac output and reduces systemic arterial load in hypertensive rats

Autor: Sanjeev G. Shroff, Lee A. Danielson, Kirk P. Conrad, Arundhathi Jeyabalan, Dan O. Debrah

Publikováno v: Hypertension (Dallas, Tex. : 1979). 46(4)

Chronic administration of recombinant human relaxin (rhRLX) to conscious, normotensive rats (male and female) increases cardiac output (CO) and global arterial compliance (AC g ) and reduces systemic vascular resistance (SVR) with no change in mean a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e88f3d724aad30ff5f401cf9246b12
https://pubmed.ncbi.nlm.nih.gov/16172427

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Troponin I protein kinase C phosphorylation sites and ventricular function

Autor: Dan O. Debrah, Sanjeev G. Shroff, Steven J. Mullet, Tom C.-C. Hu, Caroline Evans, Guy A. MacGowan, Hsiao-Huei Chen, Alan P. Koretsky, Alexandre F.R. Stewart, Charles F. McTiernan

Publikováno v: Cardiovascular research. 63(2)

Objective: Cardiac Troponin I (cTnI) phosphorylation by protein kinase C (PKC) results in a reduction of maximal actomyosin ATPase activity, an effect that is more marked at higher levels of calcium (Ca 2+ ) and is likely to reduce active force devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2226f5be6b89c3630cac16b25d6c80c2
https://pubmed.ncbi.nlm.nih.gov/15249182

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