Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Dan Mishmar"'
Autor:
Noam Shtolz, Dan Mishmar
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
The analysis of mitochondrial DNA from over 8000 metazoans shows gene content conservation, association between preference for mtDNA-encoded tRNAs and codon usage, selective constraint for mtDNA rearrangements and their impact on mtDNA transcription.
Externí odkaz:
https://doaj.org/article/e14a897ded064cf4ba7eaba961119086
Autor:
Lana Meshnik, Dan Bar-Yaacov, Dana Kasztan, Tali Neiger, Tal Cohen, Mor Kishner, Itay Valenci, Sara Dadon, Christopher J. Klein, Jeffery M. Vance, Yoram Nevo, Stephan Züchner, Ofer Ovadia, Dan Mishmar, Anat Ben-Zvi
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background Mitochondrial DNA (mtDNA) is present at high copy numbers in animal cells, and though characterized by a single haplotype in each individual due to maternal germline inheritance, deleterious mutations and intact mtDNA molecules fr
Externí odkaz:
https://doaj.org/article/b201b8a14eb44511992dfb57115e956e
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103471- (2021)
Summary: Mitochondria are pivotal for bioenergetics, as well as in cellular response to viral infections. Nevertheless, their role in COVID-19 was largely overlooked. Here, we analyzed available bulk RNA-seq datasets from COVID-19 patients and corres
Externí odkaz:
https://doaj.org/article/54cb9f499310415dae8304ed758a5b28
Publikováno v:
iScience, Vol 12, Iss , Pp 141-151 (2019)
Summary: Unlike the nuclear genome, the mammalian mitochondrial genome (mtDNA) is thought to be coated solely by mitochondrial transcription factor A (TFAM), whose binding sequence preferences are debated. Therefore, higher-order mtDNA organization i
Externí odkaz:
https://doaj.org/article/e1b38cb96e8e43ea8a9dc352fd6e12cd
Autor:
Tom Levy, Tomer Ventura, Giulio De Leo, Nufar Grinshpan, Faiza Amterat Abu Abayed, Rivka Manor, Amit Savaya, Menachem Y. Sklarz, Vered Chalifa-Caspi, Dan Mishmar, Amir Sagi
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101652- (2020)
Summary: In the Australian redclaw crayfish, Cherax quadricarinatus (WZ/ZZ system), intersexuals, although exhibiting both male and female gonopores, are functional males bearing a female genotype (WZ males). Therefore, the occurrence of the unusual
Externí odkaz:
https://doaj.org/article/28f987e1ddf34176ac895d2956f81fea
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
The higher order organization of eukaryotic and prokaryotic genomes is pivotal in the regulation of gene expression. Specifically, chromatin accessibility in eukaryotes and nucleoid accessibility in bacteria are regulated by a cohort of proteins to a
Externí odkaz:
https://doaj.org/article/430f30d2ce0c45039fa991357e0f1dd4
Autor:
Noam Shtolz, Dan Mishmar
Publikováno v:
Frontiers in Ecology and Evolution, Vol 7 (2019)
Natural selection acts on the phenotype. Therefore, many mistakenly expect to observe its signatures only in the organism, while overlooking its impact on tissues, cells and subcellular compartments. This is particularly crucial in the case of the mi
Externí odkaz:
https://doaj.org/article/ff6b0898e1a64ef7b55ea664fb3b6bca
Autor:
Dan Bar-Yaacov, Idan Frumkin, Yuka Yashiro, Takeshi Chujo, Yuma Ishigami, Yonatan Chemla, Amit Blumberg, Orr Schlesinger, Philipp Bieri, Basil Greber, Nenad Ban, Raz Zarivach, Lital Alfonta, Yitzhak Pilpel, Tsutomu Suzuki, Dan Mishmar
Publikováno v:
PLoS Biology, Vol 15, Iss 1, p e1002594 (2017)
[This corrects the article DOI: 10.1371/journal.pbio.1002557.].
Externí odkaz:
https://doaj.org/article/d68ebf9c64a34bf3b0db2f6d2a1e4ea8
Publikováno v:
PLoS Genetics, Vol 12, Iss 11, p e1006407 (2016)
Mitochondrial DNA (mtDNA) variants have been traditionally used as markers to trace ancient population migrations. Although experiments relying on model organisms and cytoplasmic hybrids, as well as disease association studies, have served to underli
Externí odkaz:
https://doaj.org/article/62f838d5b3e14a4da2a9c73b9bdf7605
Autor:
Dan Bar-Yaacov, Idan Frumkin, Yuka Yashiro, Takeshi Chujo, Yuma Ishigami, Yonatan Chemla, Amit Blumberg, Orr Schlesinger, Philipp Bieri, Basil Greber, Nenad Ban, Raz Zarivach, Lital Alfonta, Yitzhak Pilpel, Tsutomu Suzuki, Dan Mishmar
Publikováno v:
PLoS Biology, Vol 14, Iss 9, p e1002557 (2016)
The mitochondrial ribosome, which translates all mitochondrial DNA (mtDNA)-encoded proteins, should be tightly regulated pre- and post-transcriptionally. Recently, we found RNA-DNA differences (RDDs) at human mitochondrial 16S (large) rRNA position 9
Externí odkaz:
https://doaj.org/article/b0b5d25bb08e4ce4a5914113f537bc16