Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Dan M, Granoff"'
Autor:
Deirdre Nolfi-Donegan, Monica Konar, Vianca Vianzon, Jessica MacNeil, James Cooper, Perrianne Lurie, Judi Sedivy, Xin Wang, Dan M. Granoff, Lucy McNamara
Publikováno v:
Emerging Infectious Diseases, Vol 24, Iss 8, Pp 1561-1564 (2018)
Patients receiving eculizumab have an increased risk for meningococcal disease, but most reported cases are attributable to encapsulated meningococcal strains. We describe a case in which a nongroupable meningococcal strain, which rarely causes disea
Externí odkaz:
https://doaj.org/article/41a58f4f56f648ff9aee5cb31d2af7d6
Publikováno v:
Haematologica, Vol 104, Iss 8 (2019)
Externí odkaz:
https://doaj.org/article/28e6320dfc7b4682b73531bd1a9ec817
Autor:
Kelsey Sharkey, Peter T. Beernink, Joanne M. Langley, Soren Gantt, Caroline Quach, Christina Dold, Qin Liu, Manuel Galvan, Dan M. Granoff
Publikováno v:
mSphere, Vol 4, Iss 4 (2019)
ABSTRACT Meningococcal serogroup B (MenB) vaccines contain recombinant factor H binding protein (FHbp), which can complex with complement factor H (CFH) and thereby risk eliciting anti-FH autoantibodies. While anti-FH antibodies can be present in ser
Externí odkaz:
https://doaj.org/article/9530d107fca64058aee7613a681cc7e6
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT MenB-4C (Bexsero; GlaxoSmithKline Biologicals) is a licensed meningococcal vaccine for capsular B strains. The vaccine contains detergent-extracted outer membrane vesicles (dOMV) and three recombinant proteins, of which one is factor H bindi
Externí odkaz:
https://doaj.org/article/58660d846af844aab10e3e33c323b3b9
Publikováno v:
mBio, Vol 6, Iss 3 (2015)
ABSTRACT Two licensed serogroup B meningococcal vaccines contain factor H binding protein (FHbp). The antigen specifically binds human FH, which downregulates complement. In wild-type mice whose mouse FH does not bind to FHbp vaccines, the serum anti
Externí odkaz:
https://doaj.org/article/5ab94d1bfd9a40c8ad446477965f1842
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135996 (2015)
Two meningococcal serogroup B vaccines contain Factor H binding protein (FHbp). Binding of Factor H (FH) to FHbp was thought to be specific for human or chimpanzee FH. However, in a previous study an amino acid polymorphism in rhesus macaque FH domai
Externí odkaz:
https://doaj.org/article/78ab1bb2778a47949601542e4696f370
Publikováno v:
Haematologica. 104:e340-e344
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6c5d298679b4d6911aa303a7226157
https://doi.org/10.3324/haematol.2018.209692
https://doi.org/10.3324/haematol.2018.209692
Publikováno v:
mBio, Vol 5, Iss 5 (2014)
ABSTRACT The meningococcal 4CMenB vaccine (Bexsero; Novartis) contains four antigens that can elicit serum bactericidal activity, one of which is factor H (FH)-binding protein (FHbp). FHbp specifically binds human complement FH. When humans are immun
Externí odkaz:
https://doaj.org/article/f4b001426ffd418f8855483e05502b28
Autor:
Lisa A. Lewis, David M. Vu, Shreekant Vasudhev, Jutamas Shaughnessy, Dan M. Granoff, Sanjay Ram
Publikováno v:
mBio, Vol 4, Iss 5 (2013)
ABSTRACT The identification of “factor H binding protein (fHbp)-null” invasive meningococcal isolates and the realization that widespread use of fHbp-based vaccines could herald selection of such strains prompted us to characterize novel mechanis
Externí odkaz:
https://doaj.org/article/63c632cf777e49d4ba46e0a003471244
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66536 (2013)
The meningococcal serogroup A (MenA) polysaccharide conjugate vaccine used in Sub-Saharan Africa does not prevent disease caused by MenW or MenX strains, which also cause epidemics in the region. We investigated the vaccine-potential of native outer
Externí odkaz:
https://doaj.org/article/eddc3239346a448abc1ebc1396eec366