Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dan L. Czilli"'
Autor:
David M. Holtzman, Tomasz Kowalewski, Bruce D. Gitter, Dan L. Czilli, Justin Legleiter, Ronald B. DeMattos
Publikováno v:
Journal of Molecular Biology. 335:997-1006
Extensive data suggest that the conversion of the amyloid-beta (Abeta) peptide from soluble to insoluble forms is a key factor in the pathogenesis of Alzheimer's disease (AD). In recent years, atomic force microscopy (AFM) has provided useful insight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1577403f17e90b03d8aa41b9d3d6769
https://doi.org/10.1016/j.jmb.2003.11.019
https://doi.org/10.1016/j.jmb.2003.11.019
Autor:
Dan L. Czilli, J.P Butler, John E. Hale, Sheila P. Little, Mcclure Don B, Weiying Li, L.K Simmons
Publikováno v:
Neuroscience. 95:1-4
Secreted isoforms of the beta-amyloid precursor protein potently enhance neuronal survival in cell cultures exposed to toxic amyloid beta peptide. Lowering of intracellular calcium levels to offset the increases in intraneuronal calcium caused by amy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be6014c11cd38c6d2dc3727d08ef4af
https://doi.org/10.1016/s0306-4522(99)00479-0
https://doi.org/10.1016/s0306-4522(99)00479-0
Publikováno v:
Brain Research. 682:207-211
Whole-cell voltage-clamp recording and circular dichroism (CD) spectroscopy were used to assess the importance of amyloid beta peptide (A beta) conformation for eliciting homeostatically disruptive membrane conductances in embryonic rat hippocampal n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440fb343ddc4f24990fd00ab0fac3e68
https://doi.org/10.1016/0006-8993(95)00264-q
https://doi.org/10.1016/0006-8993(95)00264-q
Autor:
Claire V. Cella, Jenna Hanmer, Michael Hutton, David O. Calligaro, Aaron Simmons, Annalisa Cavallini, Peter Davies, Hugh Nuthall, Laura J. Bloem, Philip G. Szekeres, Michael J. O'Neill, Suchira Bose, Mark A Ward, Helen Sims, Jeff W. Cramer, Tracey K. Murray, Elizabeth Eberle, Lisa Baschirotto, Dan L. Czilli, Ana I. Mateo, Michel Goedert, Sandra Sossick
Publikováno v:
Alzheimer's & Dementia. 8
Background: Neurofibrillary tangles (NFT), one of the hallmarks of Alzheimer’s disease (AD), are composed of paired helical filaments (PHF) of abnormally hyperphosphorylated tau. The accumulation of these proteinaceous aggregates in AD correlates w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dd9969eb4a5cb1687792eeaf6cea0ba
https://doi.org/10.1016/j.jalz.2012.05.1243
https://doi.org/10.1016/j.jalz.2012.05.1243
Publikováno v:
Annals of the New York Academy of Sciences. 917
Neurodegenerative processes in Alzheimer's disease (AD) are thought to be driven, in part, by the deposition of amyloid beta (A beta), a 39-43-aminoacid peptide product resulting from an alternative cleavage of amyloid precursor protein (APP). In add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65299d11cf0350f2df3114803c2564f8
https://pubmed.ncbi.nlm.nih.gov/11268339
https://pubmed.ncbi.nlm.nih.gov/11268339
Publikováno v:
Neurobiology of aging. 21(5)
Amyloid precursor protein (APP) is cleaved to neurotoxic/proinflammatory amyloid beta protein (Abeta) or to the neuroprotective secreted alpha-APPs. A balance in APP metabolism may influence the outcome between toxicity and protection to central nerv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d00bd12d42cfa37d9e44453434b440
https://pubmed.ncbi.nlm.nih.gov/11016545
https://pubmed.ncbi.nlm.nih.gov/11016545
Autor:
Linda K. Simmons, Steven M. Paul, Kelly R. Bales, Binhui Ni, Jeffrey W. Horn, Elizabeth Hamilton-Byrd, Yansheng Du, Dan L. Czilli, Richard C. Dodel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 94(21)
Neurotoxicity induced by overstimulation of N -methyl- d -aspartate (NMDA) receptors is due, in part, to a sustained rise in intracellular Ca 2+ ; however, little is known about the ensuing intracellular events that ultimately result in cell death. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be13e8e37fb52cf21bb14ab67b53063
https://pubmed.ncbi.nlm.nih.gov/9326666
https://pubmed.ncbi.nlm.nih.gov/9326666
Autor:
Patrick J. C. May, Bruce D. Gitter, Tinggui Yin, Thomas Edward Mabry, Paul A. Hyslop, Mark H. Bender, Donna K. Dieckman, James E. Audia, Nissen Jeffrey S, Weiying Li, Dan L. Czilli, Mcclure Don B, Leonard N. Boggs, Edward M. Johnstone, Sheila P. Little
Publikováno v:
Neurobiology of Aging. 25:S571
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b984b8aa0622894a79080f7b45987199
https://doi.org/10.1016/s0197-4580(04)81897-9
https://doi.org/10.1016/s0197-4580(04)81897-9
Autor:
Tomasz Kowalewski, Justin Legleiter, Dave M. Holtzman, Dan L. Czilli, Bruce D. Gitter, Ronald Demattos
Publikováno v:
Neurobiology of Aging. 25:S164
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6436f679a42715f85bbfed97c3aa0410
https://doi.org/10.1016/s0197-4580(04)80553-0
https://doi.org/10.1016/s0197-4580(04)80553-0