Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dan Kiel"'
Autor:
Lars Ynddal, Ulla G. Sidelmann, Christian K. Sams, Peter Madsen, Carsten Behrens, Lotte Bjerre Knudsen, Behrend F. Lundt, Jesper Lau, Shengua Shi, Christian L. Brand, Anthony Lai Ling, Lone Pridal, Plewe Michael Bruno, Dan Kiel
Publikováno v:
Journal of Medicinal Chemistry. 50:113-128
A weak human glucagon receptor antagonist with an IC50 of 7 microM was initially found by screening of libraries originally targeted to mimic the binding of the glucagon-like peptide (GLP-1) hormone to its receptor. Optimization of this hit for bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176d2edc234cfc1c2fe14f45862ddf39
https://doi.org/10.1021/jm058026u
https://doi.org/10.1021/jm058026u
Autor:
Jesper Lau, James Lakis, Shenghua Shi, Javier Gonzalez, Teston Kimberly Ann, Lotte Bjerre Knudsen, Yufeng Hong, John M. May, Douglas E. Murphy, Atsuo Kuki, Dan Kiel, Anthony Lai Ling, Kenna Anderes, Alex Polinsky, Vlad E. Gregor, John B. Porter
Publikováno v:
Journal of Medicinal Chemistry. 44:3141-3149
High throughput screening of our small molecule combinatorial library identified a class of benzoylnaphthalenehydrazones with modest affinity for the human glucagon receptor. Optimization of this initial hit through a series of targeted libraries and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e26b8f7a7796258392d71a65a8ad93
https://doi.org/10.1021/jm000547o
https://doi.org/10.1021/jm000547o
Publikováno v:
American Journal of Physiology-Cell Physiology. 270:C885-C891
Beta-adrenergic receptor kinase is a member of the G protein-linked receptor kinase (GRK1) family that elicits receptor desensitization. We have cloned GRK2 from S49 mouse lymphoma cells. The nucleotide sequences of rat GRK2 and GRK3 were aligned and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fca804938fd0acbb338903be854aff2
https://doi.org/10.1152/ajpcell.1996.270.3.c885
https://doi.org/10.1152/ajpcell.1996.270.3.c885
Publikováno v:
Journal of Clinical Investigation. 95:1271-1280
To determine whether beta-adrenergic receptor agonist activation influences guanosine 5'-triphosphate-binding protein (G-protein) expression and beta-adrenergic receptor kinase activity in the heart, we examined the effects of chronic beta 1-adrenerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003b4923e1167ca517b2fb04b87e2222
https://doi.org/10.1172/jci117777
https://doi.org/10.1172/jci117777
Autor:
Shachi Dilip Zaveri, Dan Kiel
Publikováno v:
The FASEB Journal. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06613003ff1c318e4fb8483ee09817c6
https://doi.org/10.1096/fasebj.23.1_supplement.578.5
https://doi.org/10.1096/fasebj.23.1_supplement.578.5
Autor:
Johnson Michael David, Plewe Michael Bruno, Dan Kiel, Kimberly Ann Teston, Ulla G. Sidelmann, Douglas E. Murphy, Min Teng, Atsuo Kuki, Shenghua Shi, Christian K. Sams, James Lakis, Kenna Anderes, Larry Kenneth Truesdale, Jun Feng, Birgitte Andersen, Lars Ynddal, Peter Madsen, John M. May, Jesper Lau, Lotte Bjerre Knudsen, Anthony Lai Ling, Vlad E. Gregor, Christian L. Brand
Publikováno v:
Journal of medicinal chemistry. 45(26)
Highly potent human glucagon receptor (hGluR) antagonists have been prepared employing both medicinal chemistry and targeted libraries based on modification of the core (proximal) dimethoxyphenyl group, the benzyl ether linkage, as well as the (dista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f8de2ec1aa4425ee9bc81ce1098b95
https://pubmed.ncbi.nlm.nih.gov/12477359
https://pubmed.ncbi.nlm.nih.gov/12477359
Autor:
Christian K. Sams, Lotte Bjerre Knudsen, Teston Kimberly Ann, Eugenia A. Iatsimirskaia, Anthony Lai Ling, Atsuo Kuki, Peter Madsen, Dan Kiel, Doug Murphy, Vlad E. Gregor, Jesper Lau, Javier Gonzalez, Christian L. Brand, Plewe Michael Bruno, John M. May, James Lakis, Shenghua Shi, Larry Kenneth Truesdale, Ulla G. Sidelmann, Alex Polinsky, Kenna Anderes
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(4)
A series of alkylidene hydrazide derivatives containing an alkoxyaryl moiety was optimized. The resulting hydrazide-ethers were competitive antagonists at the human glucagon receptor. Pharmacokinetic experiments showed fast clearance of most of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1394aba7e4083e65bb5700d91b4cd2dc
https://pubmed.ncbi.nlm.nih.gov/11844695
https://pubmed.ncbi.nlm.nih.gov/11844695
Autor:
Jesper Lau, Carsten Behrens, Ulla G. Sidelmann, Lotte B. Knudsen, Behrend Lundt, Christian Sams, Lars Ynddal, Christian L. Brand, Lone Pridal, Anthony Ling, Dan Kiel, Michael Plewe, Shengua Shi, Peter Madsen
Publikováno v:
Journal of Medicinal Chemistry; Jan2007, Vol. 50 Issue 1, p113-128, 16p
Autor:
Peter Madsen, Tim Kercher, Jarek Kostrowicki, Michael D. L. Johnson, Larry Kenneth Truesdale, Shelley A. Aytes, John M. May, Johannes Cornelis De Jong, Preben H. Olesen, Lotte Bjerre Knudsen, Min Teng, Ingrid Pettersson, János Tibor Kodra, Christine Thomas, Dilip Bhumralkar, Jesper Lau, Ulla Sidelman, Carsten Behrens, Dan Kiel, James Lakis, Anker Steen Jorgensen, Jens J. Holst
Publikováno v:
CIÊNCIAVITAE
University of Copenhagen
University of Copenhagen
Following our previous publication describing the biological profiles, we herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc1ddaf454c10f0439b6442091310c5
https://curis.ku.dk/portal/en/publications/small-molecule-agoallosteric-modulators-of-the-human-glucagonlike-peptide1-hglp1-receptor(59701030-20ec-11dd-bc23-000ea68e967b).html
https://curis.ku.dk/portal/en/publications/small-molecule-agoallosteric-modulators-of-the-human-glucagonlike-peptide1-hglp1-receptor(59701030-20ec-11dd-bc23-000ea68e967b).html
