Abstract 5478: Targeting kynurenine pathway for the treatment of cisplatin-resistant lung cancer

Autor: Niramol Savaraj, Medhi Wangpaichitr, Dan Jm Nguyen, Lynn G. Feun, Chunjing Wu, Ying-Ying Li

Publikováno v: Cancer Research. 78:5478-5478

We have found that increasing ROS (reactive oxygen species) level is a specific and yet common feature found in cisplatin resistant (CR) lung cancer cells. We also showed that manipulation of ROS levels can selectively killed CR cells. Here, we have

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https://doi.org/10.1158/1538-7445.am2018-5478

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Targets and cross-reactivity of human T cell recognition of common cold coronaviruses.

Autor: Tarke A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA; Department of Experimental Medicine and Center of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, Italy., Zhang Y; J. Craig Venter Institute, La Jolla, CA 92037, USA., Methot N; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA., Narowski TM; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7290, USA., Phillips E; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA 6150, Australia., Mallal S; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA 6150, Australia., Frazier A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA., Filaci G; Center of Excellence for Biomedical Research, Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy; Biotherapy Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA., Dan JM; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA., Premkumar L; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7290, USA., Scheuermann RH; J. Craig Venter Institute, La Jolla, CA 92037, USA; Department of Pathology, University of California, San Diego (UCSD), La Jolla, CA 92037, USA. Electronic address: rscheuermann@jcvi.org., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA. Electronic address: alex@lji.org., Grifoni A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA. Electronic address: agrifoni@lji.org.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2023 Jun 20; Vol. 4 (6), pp. 101088. Date of Electronic Publication: 2023 May 29.

Development of Host Immune Response to Bacteriophage in a Lung Transplant Recipient on Adjunctive Phage Therapy for a Multidrug-Resistant Pneumonia.

Autor: Dan JM; Center for Infectious Diseases and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, California, USA., Lehman SM; AmpliPhi Biosciences, San Diego, California, USA., Al-Kolla R; Center for Infectious Diseases and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA., Penziner S; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, California, USA., Afshar K; Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, California, USA., Yung G; Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, California, USA., Golts E; Department of Surgery. Division of Cardiovascular and Thoracic Surgery, University of California, San Diego, La Jolla, California, USA., Law N; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, California, USA., Logan C; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, California, USA., Kovach Z; AmpliPhi Australia, Sydney, Australia., Mearns G; AmpliPhi Australia, Sydney, Australia., Schooley RT; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, California, USA., Aslam S; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, California, USA., Crotty S; Center for Infectious Diseases and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, California, USA.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2023 Feb 01; Vol. 227 (3), pp. 311-316.

SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines.

Autor: Bowen JE; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Park YJ; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA., Stewart C; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Brown JT; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Sharkey WK; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Walls AC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA., Joshi A; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Sprouse KR; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., McCallum M; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Tortorici MA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Franko NM; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA., Logue JK; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA., Mazzitelli IG; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Facultad de Medicina, Buenos Aires C1121ABG, Argentina., Nguyen AW; McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA., Silva RP; McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA., Huang Y; McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA., Low JS; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Jerak J; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Tiles SW; Center for Emerging and Re-emerging Infectious Diseases, Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA., Ahmed K; Departments of Paediatrics and Child Health and Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan., Shariq A; Departments of Paediatrics and Child Health and Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan., Dan JM; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA., Zhang Z; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA., Snell G; Vir Biotechnology, San Francisco, CA 94158, USA., Posavad CM; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Iqbal NT; Departments of Paediatrics and Child Health and Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan., Geffner J; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Facultad de Medicina, Buenos Aires C1121ABG, Argentina., Bandera A; Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy., Gori A; Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy., Sallusto F; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Maynard JA; McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA., Crotty S; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA., Van Voorhis WC; Center for Emerging and Re-emerging Infectious Diseases, Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA., Simmerling C; Department of Chemistry, Stony Brook University, Stony Brook, NY 11794, USA.; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794, USA., Grifantini R; INGM, Istituto Nazionale Genetica Molecolare 'Romeo ed Enrica Invernizzi,' 20122 Milan, Italy., Chu HY; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA., Corti D; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

Publikováno v: Science immunology [Sci Immunol] 2022 Dec 23; Vol. 7 (78), pp. eadf1421. Date of Electronic Publication: 2022 Dec 23.