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of 3
pro vyhledávání: '"Dan J. Sillence"'
Autor:
Simon Wheeler, Per Haberkant, Meenakshi Bhardwaj, Paige Tongue, Maria J. Ferraz, David Halter, Hein Sprong, Ralf Schmid, Johannes M.F.G. Aerts, Nikol Sullo, Dan J. Sillence
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 242-252 (2019)
Niemann-Pick type C disease (NPCD) is a neurodegenerative disease associated with increases in cellular cholesterol and glycolipids and most commonly caused by defective NPC1, a late endosomal protein. Using ratiometric probes we find that NPCD cells
Externí odkaz:
https://doaj.org/article/6fb5ca776cce47189af2095afd786cce
Autor:
Dan J. Sillence, Vishwajeet Puri, David L. Marks, Terry D. Butters, Raymond A. Dwek, Richard E. Pagano, Frances M. Platt
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 11, Pp 1837-1845 (2002)
Glycosphingolipids are endocytosed and targeted to the Golgi apparatus, but are mistargeted to lysosomes in numerous sphingolipidoses. Substrate reduction therapy utilizes imino sugars to inhibit glucosylceramide synthase and potentially abrogate the
Externí odkaz:
https://doaj.org/article/93f0bec6ded34f598cd343de4d31939f
Autor:
Dan J, Sillence
Publikováno v:
International review of cytology. 262
Glycosphingolipids are key components of eukaryotic cellular membranes. Through their propensity to form lipid rafts, they are important in membrane transport and signaling. At the cell surface, they are required for caveolar-mediated endocytosis, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3aab174795504fd8d759ac75efabaa7
https://pubmed.ncbi.nlm.nih.gov/17631188
https://pubmed.ncbi.nlm.nih.gov/17631188