Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dan Grander"'
Autor:
Iryna Kolosenko, Yasmin Yu, Sander Busker, Matheus Dyczynski, Jianping Liu, Martin Haraldsson, Caroline Palm Apergi, Thomas Helleday, Katja Pokrovskaja Tamm, Brent D G Page, Dan Grander
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178844 (2017)
Activation of Signal Transducer and Activator of Transcription 3 (STAT3) has been linked to several processes that are critical for oncogenic transformation, cancer progression, cancer cell proliferation, survival, drug resistance and metastasis. Inh
Externí odkaz:
https://doaj.org/article/3c35e110683a4648b5aa13008599cdad
Autor:
Charles Spruck, Olle Sangfelt, Martin Widschwendter, Steven I. Reed, Dan Grander, Hans Nordgren, Per Sangfelt, Fredrik Petersson, Susanne Egyhazi, Johan Hansson, Mohammad Reza Zali, Babak Noori Nayer, Sepideh Zabihi Nejad, Markus Dagnell, Martin Corcoran, Elisabeth Mueller-Holzner, Christian Marth, Dimitra Dofou, Heidi Fiegl, Diana Cepeda, Alena Maljukova, Kathleen Klotz, Sophia Apostolidou, Natalie von der Lehr, Dahui Sun, Shahab Akhoondi
The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family of proteins, which are substrate recognition components of the multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f23907af830a4be9a61f44daaab6df85
https://doi.org/10.1158/0008-5472.c.6496770
https://doi.org/10.1158/0008-5472.c.6496770
Autor:
Shahab, Akhoondi, Dahui, Sun, Natalie, von der Lehr, Sophia, Apostolidou, Kathleen, Klotz, Alena, Maljukova, Diana, Cepeda, Heidi, Fiegl, Dimitra, Dafou, Dimitra, Dofou, Christian, Marth, Elisabeth, Mueller-Holzner, Martin, Corcoran, Markus, Dagnell, Sepideh Zabihi, Nejad, Babak Noori, Nayer, Mohammad Reza, Zali, Johan, Hansson, Susanne, Egyhazi, Fredrik, Petersson, Per, Sangfelt, Hans, Nordgren, Dan, Grander, Steven I, Reed, Martin, Widschwendter, Olle, Sangfelt, Charles, Spruck
Publikováno v:
Cancer Research. 67:9006-9012
The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family of proteins, which are substrate recognition components of the multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82487509808a607b1856338430f0422d
https://doi.org/10.1158/0008-5472.can-07-1320
https://doi.org/10.1158/0008-5472.can-07-1320
Autor:
Linda Vidarsdottir, Alireza Azimi, Ishani Das, Ingibjorg Sigvaldadottir, Aldwin Suryo Rahmanto, Andreas Petri, Sakari Kauppinen, Christian Ingvar, Göran Jönsson, Håkan Olsson, Marianne Frostvik Stolt, Rainer Tuominen, Olle Sangfelt, Katja Pokrovskaja Tamm, Johan Hansson, Dan Grandér, Suzanne Egyházi Brage, Per Johnsson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract BRAF inhibitors (BRAFi) selectively target oncogenic BRAFV600E/K and are effective in 80% of advanced cutaneous malignant melanoma cases carrying the V600 mutation. However, the development of drug resistance limits their clinical efficacy.
Externí odkaz:
https://doaj.org/article/f88ae22862f24b9684552bdca23e8edf
Autor:
Sean G Rudd, Nikolaos Tsesmetzis, Kumar Sanjiv, Cynthia BJ Paulin, Lakshmi Sandhow, Juliane Kutzner, Ida Hed Myrberg, Sarah S Bunten, Hanna Axelsson, Si Min Zhang, Azita Rasti, Petri Mäkelä, Si'Ana A Coggins, Sijia Tao, Sharda Suman, Rui M Branca, Georgios Mermelekas, Elisée Wiita, Sun Lee, Julian Walfridsson, Raymond F Schinazi, Baek Kim, Janne Lehtiö, Georgios Z Rassidakis, Katja Pokrovskaja Tamm, Ulrika Warpman‐Berglund, Mats Heyman, Dan Grandér, Sören Lehmann, Thomas Lundbäck, Hong Qian, Jan‐Inge Henter, Torsten Schaller, Thomas Helleday, Nikolas Herold
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp 1-20 (2020)
Abstract The deoxycytidine analogue cytarabine (ara‐C) remains the backbone treatment of acute myeloid leukaemia (AML) as well as other haematological and lymphoid malignancies, but must be combined with other chemotherapeutics to achieve cure. Yet
Externí odkaz:
https://doaj.org/article/ee94cd1a0d794c99b66c9335300d2f1e
Autor:
Niclas Jareborg, Marianne Hammarsund, T. Dan Grander, Olga Vorontsova, Eugene R. Zabarovsky, N. K. Yankovsky, Olle Sangfelt, Ancha Baranova, Mats Merup, Stefan Einhorn, Kapanadze Bi, Monika Jansson, Martin Corcoran, N. V. Makeeva, David Oscier, Gösta Gahrton
Publikováno v:
Genomics. 70(3)
Previous studies have indicated the presence of a putative tumor suppressor gene on human chromosome 13q14, commonly deleted in patients with B-cell chronic lymphocytic leukemia (B-CLL). We have recently identified a minimally deleted region encompas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeeeef488388e3dd76295a16b10f1cd0
https://pubmed.ncbi.nlm.nih.gov/11161783
https://pubmed.ncbi.nlm.nih.gov/11161783
Autor:
Diana Cepeda, Hwee‐Fang Ng, Hamid Reza Sharifi, Salah Mahmoudi, Vanessa Soto Cerrato, Erik Fredlund, Kristina Magnusson, Helén Nilsson, Alena Malyukova, Juha Rantala, Daniel Klevebring, Francesc Viñals, Nimesh Bhaskaran, Siti Mariam Zakaria, Aldwin Suryo Rahmanto, Stefan Grotegut, Michael Lund Nielsen, Cristina Al‐Khalili Szigyarto, Dahui Sun, Mikael Lerner, Sanjay Navani, Martin Widschwendter, Mathias Uhlén, Karin Jirström, Fredrik Pontén, James Wohlschlegel, Dan Grandér, Charles Spruck, Lars‐Gunnar Larsson, Olle Sangfelt
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 7, Pp 1067-1086 (2013)
Abstract SCF (Skp1/Cul1/F‐box) ubiquitin ligases act as master regulators of cellular homeostasis by targeting key proteins for ubiquitylation. Here, we identified a hitherto uncharacterized F‐box protein, FBXO28 that controls MYC‐dependent tra
Externí odkaz:
https://doaj.org/article/5062dd7638fb498c83728c328d552d33
Autor:
Li-Di Xu, Susanne Muller, Srinivasan R Thoppe, Fredrik Hellborg, Lena Kanter, Mikael Lerner, Biying Zheng, Svetlana Bajalica Lagercrantz, Dan Grandér, Keng Ling Wallin, Klas G Wiman, Catharina Larsson, Sonia Andersson
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111125 (2014)
The p53 target gene WIG-1 (ZMAT3) is located in chromosomal region 3q26, that is frequently amplified in human tumors, including cervical cancer. We have examined the status of WIG-1 and the encoded Wig-1 protein in cervical carcinoma cell lines and
Externí odkaz:
https://doaj.org/article/1f54762391aa457bab09cefad0d5a8ab
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36490 (2012)
The pro-apoptotic p53 target Noxa is a BH3-only protein that antagonizes the function of selected anti-apoptotic Bcl-2 family members. While much is known regarding the transcriptional regulation of Noxa, its posttranscriptional regulation remains re
Externí odkaz:
https://doaj.org/article/4dfc994a34b447d2a6d93e85cad02658
Autor:
Edward Laane, Theocharis Panaretakis, Katja Pokrovskaja, Eva Buentke, Martin Corcoran, Stefan Söderhäll, Mats Heyman, Joanna Mazur, Boris Zhivotovsky, Anna Porwit, Dan Grandér
Publikováno v:
Haematologica, Vol 92, Iss 11 (2007)
Background and Objectives The mechanism of glucocorticoid -induced apoptosis is not fully understood and early predictive assays based on apoptotic markers for clinical outcome in acute lymphoblastic leukemia (ALL) are scarce. The aim of this study w
Externí odkaz:
https://doaj.org/article/3c5d216699f740b69695278a3c2ac883