Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Dan Fishlock"'
Autor:
Dan Fishlock, Ralph Diodone, Stefan Hildbrand, Bernd Kuhn, Christian Mössner, Carsten Peters, Pankaj D. Rege, Gösta Rimmler, Markus Schantz.
Publikováno v:
CHIMIA, Vol 72, Iss 7-8 (2018)
A concise asymmetric synthesis has been developed to prepare idasanutlin, a small molecule MDM2 antagonist. Idasanutlin is currently being investigated as a potential treatment for various solid tumors and hematologic malignancies. The highly congest
Externí odkaz:
https://doaj.org/article/e526a718912a47f69ee8cfdabf81f54c
Publikováno v:
Organic Letters. 24:48-52
We show that alkylidene dihydropyridines, readily prepared from 4-alkylpyridines, behave as soft nucleophiles toward a range of α,β-unsaturated ketones under the influence of silyl Lewis acids to give the products of conjugate addition. In contrast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ec3f6b91b05beea980d2b89745641a
https://doi.org/10.1021/acs.orglett.1c03615
https://doi.org/10.1021/acs.orglett.1c03615
Development and Optimization of the Manufacturing Process for RNA-Splicing Modifier Risdiplam RG7916
Autor:
Christian Moessner, Fabienne Hoffmann-Emery, Jean-Michel Adam, Serena Fantasia, Dan Fishlock, Roland Meier, Georg Wuitschik, Hasane Ratni
Publikováno v:
ACS Symposium Series ISBN: 9780841297333
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57dab2446985237000eeb07648e81769
https://doi.org/10.1021/bk-2022-1423.ch008
https://doi.org/10.1021/bk-2022-1423.ch008
Publikováno v:
ACS Catalysis. 11:3251-3256
We report a mild palladium-catalyzed selective dehydrogenation of 4-alkylpyridines that exploits their soft enolization to alkylidene dihydropyridines using allyl chloroformate under metal-free con...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a30547b3b32f054489bf11c56203d6f
https://doi.org/10.1021/acscatal.0c05209
https://doi.org/10.1021/acscatal.0c05209
Autor:
Brian Doan, Jiaqi Shi, Dan Fishlock, Faizan Rasheed, Raphaël Robidas, Isabelle Hunter, Nour Wasfy, Arturo Orellana, Claude Y. Legault
Publikováno v:
Chemical Science. 12:1503-1512
We report a mild palladium-catalyzed method for the selective allylation of 4-alkylpyridines in which highly basic pyridylic anions behave as soft nucleophiles. This method exploits alkylidene dihydropyridines, which are semi-stable intermediates rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95deb942ad1ff954b23533145cbb0cda
https://doi.org/10.1039/d0sc03304a
https://doi.org/10.1039/d0sc03304a
Autor:
Nour, Wasfy, Faizan, Rasheed, Raphaël, Robidas, Isabelle, Hunter, Jiaqi, Shi, Brian, Doan, Claude Y, Legault, Dan, Fishlock, Arturo, Orellana
Publikováno v:
Chemical Science
We report a mild palladium-catalyzed method for the selective allylation of 4-alkylpyridines in which highly basic pyridylic anions behave as soft nucleophiles. This method exploits alkylidene dihydropyridines, which are semi-stable intermediates rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::81f640580020542a9c2f368a9164895e
https://pubmed.ncbi.nlm.nih.gov/34163914
https://pubmed.ncbi.nlm.nih.gov/34163914
Autor:
Marcello Bosco, Christian Moessner, Carsten Peters, Stefan Hildbrand, Bernd Kuhn, Gösta Rimmler, Pankaj D. Rege, Dan Fishlock, André Alker, Markus Schantz, Ralph Diodone
Publikováno v:
Organic Process Research & Development. 20:2057-2066
A concise catalytic asymmetric synthesis of idasanutlin (1) was developed in which the key pyrrolidine core, containing four contiguous stereocenters, was constructed via a Ag/MeOBIPHEP promoted [3 + 2] cycloaddition reaction. Further development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b6811c01cb3dd450dd79de4b64da146
https://doi.org/10.1021/acs.oprd.6b00319
https://doi.org/10.1021/acs.oprd.6b00319
Publikováno v:
Organic Process Research & Development. 20:2050-2056
An efficient asymmetric synthesis of MDM2 antagonist RG7388 is reported. The highly functionalized chiral pyrrolidine carboxamide was assembled via a Cu(OAc)2/(R)-BINAP catalyzed asymmetric [3 + 2] cycloaddition, which gave the exo and endo adducts i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3361f0dd9a1fce0e5fe0d92e1248bb9a
https://doi.org/10.1021/acs.oprd.6b00320
https://doi.org/10.1021/acs.oprd.6b00320
Autor:
Ralph Diodone, Carsten Peters, Bernd Kuhn, Markus Schantz, Christian Mössner, Gösta Rimmler, Stefan Hildbrand, Dan Fishlock, Pankaj D. Rege
Publikováno v:
CHIMIA, Vol 72, Iss 7-8 (2018)
A concise asymmetric synthesis has been developed to prepare idasanutlin, a small molecule MDM2 antagonist. Idasanutlin is currently being investigated as a potential treatment for various solid tumors and hematologic malignancies. The highly congest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3bcc993093bbde6dc3a7df69f196b0
https://pubmed.ncbi.nlm.nih.gov/30158012
https://pubmed.ncbi.nlm.nih.gov/30158012
Autor:
Beat Wirz, Martin Ebeling, Dennis Wetzl, Michael Müller, Hans Iding, Dan Fishlock, Marco Berrera, Nicolas Sandon, Steven P. Hanlon
Publikováno v:
ChemBioChem. 16:1749-1756
Recent investigations on imine reductases (IREDs) have enriched the toolbox of potential catalysts for accessing chiral amines, which are important building blocks for the pharmaceutical industry. Herein, we describe the characterization of 20 new IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78fe00c437e469e823e85035c8323c9
https://doi.org/10.1002/cbic.201500218
https://doi.org/10.1002/cbic.201500218