Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Dan Fabris"'
Autor:
Justin M. Waldern, Dorie Smith, Carol Lyn Piazza, E. Jake Bailey, Nicholas J. Schiraldi, Reza Nemati, Dan Fabris, Marlene Belfort, Olga Novikova
Publikováno v:
Mobile DNA, Vol 12, Iss 1, Pp 1-20 (2021)
Abstract Background Group II introns are mobile retroelements, capable of invading new sites in DNA. They are self-splicing ribozymes that complex with an intron-encoded protein to form a ribonucleoprotein that targets DNA after splicing. These molec
Externí odkaz:
https://doaj.org/article/3060b5bd7d624edc9c8156bc8e2e2450
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 582 (2022)
After a long limbo, RNA has gained its credibility as a druggable target, fully earning its deserved role in the next generation of pharmaceutical R&D. We have recently probed the trans-activation response (TAR) element, an RNA stem–bulge–loop do
Externí odkaz:
https://doaj.org/article/048df07c2e274fd6adcb5f4b27cfd1c7
Publikováno v:
Molecules, Vol 26, Iss 7, p 1874 (2021)
Specific RNA sequences regulate functions essential to life. The Trans-Activation Response element (TAR) is an RNA stem–bulge–loop structure involved in several steps of HIV-1 replication. In this work, we show how RNA targeting can inhibit HIV-1
Externí odkaz:
https://doaj.org/article/f3527f9303274e92be19f155f99a1b3b
Autor:
Shane Breznak, Yingshi Peng, Limin Deng, Noor M. Kotb, Zachary Flamholz, Ian T. Rapisarda, Elliot T. Martin, Kara A. LaBarge, Dan Fabris, Elizabeth R. Gavis, Prashanth Rangan
Stem cells in many systems, including Drosophila germline stem cells (GSCs), increase ribosome biogenesis and translation during terminal differentiation. Here, we show that pseudouridylation of ribosomal RNA (rRNA) mediated by the H/ACA box is requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::369d3850ab099b0ec9a2a1c621eb45c1
https://doi.org/10.1101/2022.07.07.499147
https://doi.org/10.1101/2022.07.07.499147
Autor:
Thomas, Kenderdine, Dan, Fabris
Publikováno v:
Mass Spectrometry Reviews.
The deceptively simple concepts of mass determination and fragment analysis are the basis for the application of mass spectrometry (MS) to a boundless range of analytes, including fundamental components and polymeric forms of nucleic acids (NAs). Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1968c5197a98a386b5316ff385884c
https://doi.org/10.1002/mas.21766
https://doi.org/10.1002/mas.21766
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 582
International Journal of Molecular Sciences, Vol 23, Iss 582, p 582 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 582, p 582 (2022)
International Journal of Molecular Sciences
After a long limbo, RNA has gained its credibility as a druggable target, fully earning its de-served role in the next-generation area of pharmaceutical R&D. We have recently probed the Trans-Activation Response element (TAR), a RNA stem–bulge–lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c87eedd5129299856f43ae4d97b95c
https://doi.org/10.20944/preprints202112.0225.v1
https://doi.org/10.20944/preprints202112.0225.v1
Autor:
Marlene Belfort, Jing Zhang, Binbin Liu, Georges Belfort, Reza Nemati, Zhong Li, Dan Fabris, Matteo Scalabrin, C. Seth Pearson, Hongmin Li
Publikováno v:
Biotechnology and Bioengineering. 116:709-721
We have engineered an intein which spontaneously and reversibly forms a thiazoline ring at the native N-terminal Lys-Cys splice junction. We identified conditions to stablize the thiazoline ring and provided the first crystallographic evidence, at 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::687fd51bb2285308d4c8f20e3584ba3c
https://doi.org/10.1002/bit.26875
https://doi.org/10.1002/bit.26875
Autor:
Marlene Belfort, Dorie Smith, Reza Nemati, Justin M. Waldern, E. Jake Bailey, Carol Lyn Piazza, Dan Fabris, Olga Novikova, Nicholas J. Schiraldi
Publikováno v:
Mobile DNA
Mobile DNA, Vol 12, Iss 1, Pp 1-20 (2021)
Mobile DNA, Vol 12, Iss 1, Pp 1-20 (2021)
Background Group II introns are mobile retroelements, capable of invading new sites in DNA. They are self-splicing ribozymes that complex with an intron-encoded protein to form a ribonucleoprotein that targets DNA after splicing. These molecules can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fb473766041900518d10cf24fab63f
http://europepmc.org/articles/PMC7938551
http://europepmc.org/articles/PMC7938551
Autor:
Ajit S. Puri, Helene Tran, Thomas Kenderdine, Robert Bowser, Dan Fabris, Huiya Yang, Catherine Douthwright, Robert M Brown, Jonathan K. Watts, Robert M. King, Alexandra Weiss, Jake Metterville, Heather L. Gray-Edwards, M Marosfoi, Michael P. Moazami, Diane McKenna-Yasek, Courtney Pinto, Minwook Shin, Craig Dooley, Nitasha Sanil, Nichols Wightman
Expansions of a G4C2 repeat in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating adult-onset neurodegenerative disorders. Proposed disease mechanisms include a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4669fa026cb2d1644bb2d30cdc512442
https://doi.org/10.21203/rs.3.rs-211236/v1
https://doi.org/10.21203/rs.3.rs-211236/v1
Autor:
Dan Fabris
Publikováno v:
Ion Mobility-Mass Spectrometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa48fdfd80eb686084359e5036849041
https://doi.org/10.1039/9781839162886-00461
https://doi.org/10.1039/9781839162886-00461