Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Dan F. Savage"'
Autor:
Gina Siddiqui, Dan F. Savage, Katherine Couturier, Alyssa B. Zupon, Matthew James, Ting‐Xu Tan, Arjun K. Venkatesh, Edward R. Melnick, Craig Rothenberg
Publikováno v:
International journal of clinical practice. 73(2)
BACKGROUND Clinical practice guidelines (CPGs) have been published by the American College of Emergency Physicians (ACEP) since 1990 to advance evidence-based emergency care. ACEP clinical policies have drawn anecdotal criticism for bias, yet the ove
Autor:
Richard E. Middleton, Valentina V. Jeliazkova-Mecheva, Damaris Diaz, Candia M. Kenific, George N. Nikov, Sanjiv J. Shah, Adam J. Schell, Bethany Hughes, Nadja Smotrov, Alexander A. Szewczak, Melanie Bouthillette, Hugh Nuthall, Deborah Walker, W. Colby Brown, Mark S. Shearman, Hua Zhou, Benito Munoz, Christian Fischer, Dan F. Savage, Joey L. Methot, Jonathan C. Cruz, Susan L. Zultanski, Nathan Bays, Dawn M. Mampreian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4083-4087
Synthesis, SAR, and evaluation of aryl triazoles as novel gamma secretase modulators (GSMs) are presented in this communication. Starting from the literature and in-house leads, we evaluated a range of five-membered heterocycles as replacements for o
Publikováno v:
FEBS Letters. 580:5198-5202
Dihydrouridine is one of the most abundant modified bases in tRNA. However, little is known concerning the biochemistry of dihydrouridine synthase (DUS) enzymes. To identify molecular determinants that are necessary for DUS activity, we have develope
Autor:
Arjun K. Venkatesh, Kenneth R. Bernard, Jeremiah D. Schuur, Benjamin J. Sandefur, Craig Rothenberg, Dan F. Savage
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 6, p e0178456 (2017)
PLoS ONE, Vol 12, Iss 6, p e0178456 (2017)
Introduction Over 25 years, emergency medicine in the United States has amassed a large evidence base that has been systematically assessed and interpreted through ACEP Clinical Policies. While not previously studied in emergency medicine, prior work
Autor:
George N. Nikov, Flobert Tanga, Chris Moxham, Ziping Yang, Chaomin Li, Richard G. Ball, Joshua Close, Richard W. Heidebrecht, Gloria Y. Kwei, Lin Xu, Laura Surdi, Xiaoliu Geng, Candia Kenefic, Sanjiv J. Shah, Dan F. Savage, Valentina V. Jeliazkova-Mecheva, Jennifer Chapnick, Julie Elizabeth Burke, Solomon Kattar, Bethany Hughes, Lily Y. Moy, Sujal V. Deshmukh, Paul Moses, Damaris Diaz, John Kevin Leach, Paul Tempest, John Hendrix, Amanda Markarewicz, Nadya Smotrov, Ilona Kariv, Michael J. McNevin, Ben Munoz, Mark S. Shearman, Thomas A. Miller
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(9)
Alzheimer’s disease is a major unmet medical need with pathology characterized by extracellular proteinaceous plaques comprised primarily of β-amyloid. γ-Secretase is a critical enzyme in the cellular pathway responsible for the formation of a ra
Publikováno v:
The BMJ
Scopus-Elsevier
Scopus-Elsevier
OBJECTIVE: To characterise the percentage of available outcome data being presented in reports of randomised clinical trials with continuous outcome measures, thereby determining the potential for incomplete reporting bias. DESIGN: Descriptive cross
Publikováno v:
Annals of Emergency Medicine. 66:S5