Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Dan Dan Shen"'
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
ObjectivesTo investigate whether glioma isocitrate dehydrogenase (IDH) 1 mutation and vascular endothelial growth factor (VEGF) expression can be estimated by histogram analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).Method
Externí odkaz:
https://doaj.org/article/056a860b571047c5a6be1b20078c230b
Autor:
Xiangyu Ma, Li-Nan Chen, Menghui Liao, Liyan Zhang, Kun Xi, Jiamin Guo, Cangsong Shen, Dan-Dan Shen, Pengjun Cai, Qingya Shen, Jieyu Qi, Huibing Zhang, Shao-Kun Zang, Ying-Jun Dong, Luwei Miao, Jiao Qin, Su-Yu Ji, Yue Li, Jianfeng Liu, Chunyou Mao, Yan Zhang, Renjie Chai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The class C orphan G-protein-coupled receptor (GPCR) GPR156, which lacks the large extracellular region, plays a pivotal role in auditory function through Gi2/3. Here, we firstly demonstrate that GPR156 with high constitutive activity is ess
Externí odkaz:
https://doaj.org/article/eda175ba92a2443a9b31648e453755f1
Autor:
Weizhu Huang, Nan Jin, Jia Guo, Cangsong Shen, Chanjuan Xu, Kun Xi, Léo Bonhomme, Robert B. Quast, Dan-Dan Shen, Jiao Qin, Yi-Ru Liu, Yuxuan Song, Yang Gao, Emmanuel Margeat, Philippe Rondard, Jean-Philippe Pin, Yan Zhang, Jianfeng Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The structural basis for the allosteric interactions within G protein-coupled receptors (GPCRs) heterodimers remains largely unknown. The metabotropic glutamate (mGlu) receptors are complex dimeric GPCRs important for the fine tuning of many
Externí odkaz:
https://doaj.org/article/2e27b6adc47142ca827758ef4b87e438
Autor:
Qingya Shen, Xinyan Tang, Xin Wen, Shizhuo Cheng, Peng Xiao, Shao‐Kun Zang, Dan‐Dan Shen, Lei Jiang, Yanrong Zheng, Huibing Zhang, Haomang Xu, Chunyou Mao, Min Zhang, Weiwei Hu, Jin‐Peng Sun, Yan Zhang, Zhong Chen
Publikováno v:
Advanced Science, Vol 11, Iss 23, Pp n/a-n/a (2024)
Abstract G‐protein‐coupled receptors (GPCRs) transmit downstream signals predominantly via G‐protein pathways. However, the conformational basis of selective coupling of primary G‐protein remains elusive. Histamine receptors H2R and H3R coupl
Externí odkaz:
https://doaj.org/article/8143a64c78c74d9eab3c2726cae8a215
Autor:
Chunyou Mao, Mengru Gao, Shao-Kun Zang, Yanqing Zhu, Dan-Dan Shen, Li-Nan Chen, Liu Yang, Zhiwei Wang, Huibing Zhang, Wei-Wei Wang, Qingya Shen, Yanhui Lu, Xin Ma, Yan Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Hydroxycarboxylic acids are crucial metabolic intermediates involved in various physiological and pathological processes, some of which are recognized by specific hydroxycarboxylic acid receptors (HCARs). HCAR2 is one such receptor, activate
Externí odkaz:
https://doaj.org/article/3d12386a7f56474cb3159fa3507635cb
Autor:
M A A Mamun, Yu Zhang, Jin-Yuan Zhao, Dan-Dan Shen, Ting Guo, Yi-Chao Zheng, Li-Juan Zhao, Hong-Min Liu
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-18 (2023)
Abstract Dysregulation of various cells in the tumor microenvironment (TME) causes immunosuppressive functions and aggressive tumor growth. In combination with immune checkpoint blockade (ICB), epigenetic modification-targeted drugs are emerging as a
Externí odkaz:
https://doaj.org/article/6534692e6a934b02adba820e03bdc48a
Autor:
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xinheng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shuyang Zhang, Yan Zhang, H. Eric Xu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Follicle stimulating hormone (FSH) is a glycoprotein hormone the functions of which are mediated by a G protein-coupled receptor, FSHR. Here, Duan et al. report cryo-EM structures of FSHR in active and inactive states, suggesting the molecular basis
Externí odkaz:
https://doaj.org/article/856683e70c7b4674b3561a58992980ab
Autor:
Su-Yu Ji, Ying-Jun Dong, Li-Nan Chen, Shao-Kun Zang, Jiawei Wang, Dan-Dan Shen, Jia Guo, Jiao Qin, Huibing Zhang, Wei-Wei Wang, Qingya Shen, Yan Zhang, Zhangfa Song, Chunyou Mao
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/a7fc1e0cc4d14a0da525d817e3d4874d
Autor:
Yu Ding, Huibing Zhang, Yu-Ying Liao, Li-Nan Chen, Su-Yu Ji, Jiao Qin, Chunyou Mao, Dan-Dan Shen, Lin Lin, Hao Wang, Yan Zhang, Xiao-Ming Li
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-16 (2022)
Abstract The intestinal hormone and neuromodulator cholecystokinin (CCK) receptors CCK1R and CCK2R act as a signaling hub in brain–gut axis, mediating digestion, emotion, and memory regulation. CCK receptors exhibit distinct preferences for ligands
Externí odkaz:
https://doaj.org/article/e285608cbc6e41eab15696ca955bdfa1
Autor:
Zhehua Shao, Yangxia Tan, Qingya Shen, Li Hou, Bingpeng Yao, Jiao Qin, Peiyu Xu, Chunyou Mao, Li-Nan Chen, Huibing Zhang, Dan-Dan Shen, Chao Zhang, Weijie Li, Xufei Du, Fei Li, Zhi-Hua Chen, Yi Jiang, H. Eric Xu, Songmin Ying, Honglei Ma, Yan Zhang, Huahao Shen
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes:
Externí odkaz:
https://doaj.org/article/ddfaf8d72624436ea3ba8d6100f0cbf8