Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Dan Cashion"'
Autor:
Dan Zhu, Xiaohui Peng, Dale Robinson, Riggs Jennifer, Kimberly E. Fultz, Julius Apuy, Tam Minh Tran, Jan Elsner, Rama K. Narla, Katerina Leftheris, Sogole Bahmanyar, Dan Cashion, Lida Tehrani, Laurie LeBrun, John F. Boylan
Publikováno v:
Journal of Medicinal Chemistry. 64:12670-12679
TTK is an essential spindle assembly checkpoint enzyme in many organisms. It plays a central role in tumor cell proliferation and is aberrantly overexpressed in a wide range of tumor types. We recently reported on a series of potent and selective TTK
Autor:
Kate Blease, Garth Ringheim, Eduardo Torres, Jeffrey Muir, Laurie LeBrun, Veronique Plantevin-Krenitsky, Ashutosh Kulkarni, Maria Celeridad, Eun Mi Hur, Hegde Sayee Gajanan, Dehua Huang, Brian E. Cathers, John Sapienza, Henry Chan, Brydon Bennett, Katerina Leftheris, Correa Matthew D, Zheng Liu, Deborah S Mortensen, Brandon Whitefield, Mercedes Delgado, Dan Cashion, Sogole Bahmanyar, Lisa Morrison, Roli Khattri, Jason Parnes, Stephen Norris, Roy Harris, Kelven Burnett, Joshua Hansen, Godrej Khambatta, Patrick Papa
Publikováno v:
Journal of Medicinal Chemistry. 64:11886-11903
The PKC-θ isoform of protein kinase C is selectively expressed in T lymphocytes and plays an important role in the T cell antigen receptor (TCR)-triggered activation of mature T cells, T cell proliferation, and the subsequent release of cytokines su
Autor:
Xiaohui Peng, Rama K. Narla, Kevin Ronald Condroski, Nagy Mark A, John F. Boylan, Jennifer Riggs, Jan Elsner, Ashutosh A. Kulkarni, Dale Robinson, Kimberly Elizabeth Fultz, Dan Zhu, Tam Tran, Dan Cashion, Lida Tehrani, Katerina Leftheris, Laurie LeBrun, Barbra Pagarigan, Sogole Bahmanyar, Gustavo Fenalti
Publikováno v:
Journal of medicinal chemistry. 62(9)
Triple negative breast cancer (TNBC) is an aggressive disease with high relapse rates and few treatment options. Outlined in previous publications, we identified a series of potent, dual TTK/CLK2 inhibitors with strong efficacy in TNBC xenograft mode