Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Dan C Wilkinson"'
Autor:
Dan C Wilkinson, Elizabeth Tallman, Mishal Ashraf, Tatiana Gelaf Romer, Jeehoon Lee, Benjamin Burnett, Pierre R Bushel
Publikováno v:
Bioinformatics and Biology Insights, Vol 18 (2024)
Single-cell RNA sequencing (scRNA-seq) allows for an unbiased assessment of cellular phenotypes by enabling the extraction of transcriptomic data. An important question in downstream analysis is how to evaluate biological similarities and differences
Externí odkaz:
https://doaj.org/article/970715216ad04d6f9b4dd42e19ea2bab
Autor:
Chandani Sen, Caroline R. Koloff, Souvik Kundu, Dan C. Wilkinson, Juliette M. Yang, David W. Shia, Luisa K. Meneses, Tammy M. Rickabaugh, Brigitte N. Gomperts
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Small-cell-lung-cancer (SCLC) has the worst prognosis of all lung cancers because of a high incidence of relapse after therapy. While lung cancer is the second most common malignancy in the US, only about 10% of cases of lung cancer are
Externí odkaz:
https://doaj.org/article/2af5fac1373f4220879f3a52faeb2175
Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule
Autor:
Preethi Vijayaraj, Aspram Minasyan, Abdo Durra, Saravanan Karumbayaram, Mehrsa Mehrabi, Cody J. Aros, Sarah D. Ahadome, David W. Shia, Katherine Chung, Jenna M. Sandlin, Kelly F. Darmawan, Kush V. Bhatt, Chase C. Manze, Manash K. Paul, Dan C. Wilkinson, Weihong Yan, Amander T. Clark, Tammy M. Rickabaugh, W. Dean Wallace, Thomas G. Graeber, Robert Damoiseaux, Brigitte N. Gomperts
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3488-3505.e9 (2019)
Summary: Progressive organ fibrosis accounts for one-third of all deaths worldwide, yet preclinical models that mimic the complex, progressive nature of the disease are lacking, and hence, there are no curative therapies. Progressive fibrosis across
Externí odkaz:
https://doaj.org/article/d90d9879ef6b4ac98aad3a2310cc1d88
Autor:
Chandani Sen, Caroline Koloff, Souvik Kundu, Dan C Wilkinson, Juliette Yang, David W Shia, Luisa K Meneses, Tammy M Rickabaugh, Brigitte N Gomperts
Publikováno v:
bioRxiv
Small-cell-lung-cancer (SCLC) has the worst prognosis of all lung cancers because of a high incidence of relapse after therapy. We developed a bioengineered 3-dimensional (3D) SCLC co-culture organoid as a phenotypic tool to study SCLC tumor kinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93bd04911c72237c844858017587947a
https://doi.org/10.1101/2023.01.03.522668
https://doi.org/10.1101/2023.01.03.522668
Autor:
Stefan Irion, Dan C. Wilkinson
Publikováno v:
Cell and Gene Therapy Insights. 5:85-96
Autor:
Preethi Vijayaraj, Bruce Dunn, Manash K. Paul, Cody J. Aros, Susan H. Guttentag, Jennifer M.S. Sucre, Brigitte N. Gomperts, Dan C. Wilkinson
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 312:L186-L195
Bronchopulmonary dysplasia (BPD) is a common complication of premature birth. The histopathology of BPD is characterized by an arrest of alveolarization with fibroblast activation. The Wnt/β-catenin signaling pathway is important in early lung devel
Autor:
Dan C, Wilkinson, Michael, Mellody, Luisa K, Meneses, Ashley C, Hope, Bruce, Dunn, Brigitte N, Gomperts
Publikováno v:
Current protocols in stem cell biology. 46(1)
This unit describes a protocol for generation of lung organoids. A lung organoid is a 3D cell/hydrogel composite that resembles the morphology and cellular composition of the human distal lung. These tissue-engineered constructs provide an in vitro m
Autor:
Chun-Han Lai, Sossina M. Haile, Dan C. Wilkinson, Michael J. Ignatowich, Danielle C. Casillas, Stephen K. Wilke, Bruce Dunn
The use of ceria-based inverse opals as a catalyst system for the thermochemical production of fuels from sunlight offers the potential of improved fuel production kinetics over materials with random porosity. Quantitative methods for characterizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ad9ff912575b451d367536707293cc
https://resolver.caltech.edu/CaltechAUTHORS:20170623-091326652
https://resolver.caltech.edu/CaltechAUTHORS:20170623-091326652
Autor:
Bruce Dunn, Jennifer M.S. Sucre, Saravanan Karumbayaram, Brigitte N. Gomperts, Dan C. Wilkinson, Jackelyn A. Alva-Ornelas, Steven J. Jonas, Preethi Vijayaraj, Abdo Durra, Wade Richardson, Manash K. Paul
Publikováno v:
Stem cells translational medicine, vol 6, iss 2
Stem Cells Translational Medicine
Wilkinson, DC; Alva-Ornelas, JA; Sucre, JMS; Vijayaraj, P; Durra, A; Richardson, W; et al.(2017). Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling.. Stem cells translational medicine, 6(2), 622-633. doi: 10.5966/sctm.2016-0192. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2pj736mr
Stem Cells Translational Medicine
Wilkinson, DC; Alva-Ornelas, JA; Sucre, JMS; Vijayaraj, P; Durra, A; Richardson, W; et al.(2017). Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling.. Stem cells translational medicine, 6(2), 622-633. doi: 10.5966/sctm.2016-0192. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2pj736mr
Stem cell technologies, especially patient-specific, induced stem cell pluripotency and directed differentiation, hold great promise for changing the landscape of medical therapies. Proper exploitation of these methods may lead to personalized organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4aa664058d7985e9f63e2699240343
https://escholarship.org/uc/item/2pj736mr
https://escholarship.org/uc/item/2pj736mr
Publikováno v:
Journal of biophotonics, vol 8, iss 7
The development of new methods for the early diagnosis of cartilage disease could offer significant improvement in patient care. Raman spectroscopy is an emerging biomedical technology with unique potential to recognize disease tissues, though diffic