Toll-like receptors and their soluble forms differ in the knee and thumb basal osteoarthritic joints

Autor: Goncalo Barreto, Jerker Sandelin, Abdelhakim Salem, Dan C Nordström, Eero Waris

Publikováno v: Acta Orthopaedica, Vol 88, Iss 3, Pp 326-333 (2017)

Background and purpose — Although the pathogenesis of osteoarthritis (OA) is not well understood, chondrocyte-mediated inflammatory responses (triggered by the activation of innate immune receptors by damage-associated molecules) are thought to be

Externí odkaz: https://doaj.org/article/8cd2c7b6ee2e4c3685cc19b7dc26fbdf

Uptake and effectiveness of newer biologic and targeted synthetic disease-modifying antirheumatic drugs in psoriatic arthritis: results from five Nordic biologics registries

Autor: Bente Glintborg, Daniela Di Giuseppe, Johan Karlsson Wallman, Dan C Nordström, Bjorn Gudbjornsson, Merete Lund Hetland, Johan Askling, Gerdur Grondal, Tuulikki Sokka, Sella A Provan, Brigitte Michelsen, Eirik Klami Kristianslund, Lene Dreyer, Thorvardur Jon Love, Ulf Lindström

Publikováno v: Glintborg, B, Di Giuseppe, D, Wallman, J K, Nordström, D C, Gudbjornsson, B, Hetland, M L, Askling, J, Grondal, G, Sokka, T, Provan, S A, Michelsen, B, Kristianslund, E K, Dreyer, L, Love, T J & Lindström, U 2023, ' Uptake and effectiveness of newer biologic and targeted synthetic disease-modifying antirheumatic drugs in psoriatic arthritis : results from five Nordic biologics registries ', Annals of the Rheumatic Diseases, vol. 82, no. 6, 223650, pp. 820-828 . https://doi.org/10.1136/ard-2022-223650

Background: We aimed to describe the uptake of newer biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in psoriatic arthritis (PsA) in the Nordic countries and to compare their retention and effectiveness.Methods: Pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8858b27ab71581cbcda850e6567b5150
https://doi.org/10.1136/ard-2022-223650

Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31 846 patients with rheumatoid arthritis in 19 registers from the 'JAK-pot' collaboration

Autor: Kim Lauper, Michele Iudici, Denis Mongin, Sytske Anne Bergstra, Denis Choquette, Catalin Codreanu, René Cordtz, Diederik De Cock, Lene Dreyer, Ori Elkayam, Ellen-Margrethe Hauge, Doreen Huschek, Kimme L Hyrich, Florenzo Iannone, Nevsun Inanc, Lianne Kearsley-Fleet, Eirik Klami Kristianslund, Tore K Kvien, Burkhard F Leeb, Galina Lukina, Dan C Nordström, Karel Pavelka, Manuel Pombo-Suarez, Ziga Rotar, Maria Jose Santos, Anja Strangfeld, Patrick Verschueren, Delphine Sophie Courvoisier, Axel Finckh

Publikováno v: Annals of the Rheumatic Diseases, 81(10). BMJ PUBLISHING GROUP
Lauper, K, Hyrich, K L, Kearsley-Fleet, L & et al. 2022, ' Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31,846 patients with rheumatoid arthritis in 19 registers from the “JAK-pot” collaboration ', Annals of the rheumatic diseases . https://doi.org/10.1136/annrheumdis-2022-222586
Lauper, K, Ludici, M, Mongin, D, Bergstra, S A, Choquette, D, Codreanu, C, Cordtz, R, De Cock, D, Dreyer, L, Elkayam, O, Hauge, E-M, Huschek, D, Hyrich, K L, Iannone, F, Inanc, N, Kearsley-Fleet, L, Kristianslund, E K, Kvien, T K, Leeb, B F, Lukina, G, Nordström, D C, Pavelka, K, Pombo-Suarez, M, Rotar, Z, Santos, M J, Strangfeld, A, Verschueren, P, Courvoisier, D S & Finckh, A 2022, ' Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31 846 patients with rheumatoid arthritis in 19 registers from the 'JAK-pot' collaboration ', Annals of the Rheumatic Diseases, vol. 81, no. 10, 222586, pp. 1358-1366 . https://doi.org/10.1136/annrheumdis-2022-222586
Lauper, K, Iudici, M, Mongin, D, Bergstra, S A, Choquette, D, Codreanu, C, Cordtz, R, De Cock, D, Dreyer, L, Elkayam, O, Hauge, E M, Huschek, D, Hyrich, K L, Iannone, F, Inanc, N, Kearsley-Fleet, L, Kristianslund, E K, Kvien, T K, Leeb, B F, Lukina, G, Nordström, D C, Pavelka, K, Pombo-Suarez, M, Rotar, Z, Santos, M J, Strangfeld, A, Verschueren, P, Courvoisier, D S & Finckh, A 2022, ' Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31 846 patients with rheumatoid arthritis in 19 registers from the 'JAK-pot' collaboration ', Annals of the Rheumatic Diseases, vol. 81, no. 10, pp. 1358-1366 . https://doi.org/10.1136/annrheumdis-2022-222586

BackgroundJAK-inhibitors (JAKi), recently approved in rheumatoid arthritis (RA), have changed the landscape of treatment choices. We aimed to compare the effectiveness of four current second-line therapies of RA with different modes of action, since

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05814942d68a76c3ecb33d7f6c01ede0
http://hdl.handle.net/10138/349608

Correlations between macrophage polarizing cytokines, inflammatory mediators, osteoclast activity, and toll-like receptors in tissues around aseptically loosened hip implants

Autor: Eemeli, Jämsen, Vesa-Petteri, Kouri, Mari, Ainola, Stuart B, Goodman, Dan C, Nordström, Kari K, Eklund, Jukka, Pajarinen

Publikováno v: Journal of biomedical materials research. Part A. 105(2)

Aseptic loosening and osteolysis of joint replacements are driven by macrophage-mediated inflammatory reactions to implant-derived wear debris, but many aspects of these events remain poorly characterized. To better understand the relationships among

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::86d92fda55e482d036b9bd66fbc76f2a
https://pubmed.ncbi.nlm.nih.gov/27669374

[Clinical picture and treatment of osteoarthritis]

Autor: Yrjö T, Konttinen, Lauri, Lindroos, Pasi, Ruuttila, Tuomas, Lähdeoja, Jan, Lassus, Dan C, Nordström, Seppo, Santavirta

Publikováno v: Duodecim; laaketieteellinen aikakauskirja. 119(16)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eba71f606e1093a2b41f9e1eee778527
https://pubmed.ncbi.nlm.nih.gov/14535026