Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Dan A. Markham"'
Autor:
R. N. Shiotsuka, Robert A. Budinsky, Dragomir I. Draganov, Dieter Beyer, Stephen Dimond, Stephanie A. Snyder, John M. Waechter, Kimberly D. Ehman, Steven G. Hentges, Dan A. Markham
Publikováno v:
Toxicology. 333:168-178
Orally administered bisphenol A (BPA) undergoes efficient first-pass metabolism to produce the inactive conjugates BPA-glucuronide (BPA-G) and BPA-sulfate (BPA-S). This study was conducted to evaluate the pharmacokinetics of BPA, BPA-G and BPA-S in n
Autor:
B. Hughes, Amy J. Clark, Jen L. Staley, Michael J. Bartels, Dan A. Markham, Tom S. Lardie, Fagen Zhang, Nicholas Ball
Publikováno v:
Toxicology Letters. 232:175-181
Diisobutyl ketone (DIBK) and diisobutyl carbinol (DIBC) are important organic solvents widely used as industrial intermediates. It was hypothesized that DIBC and DIBK have common metabolic pathways and metabolites, and as such, toxicological data on
Publikováno v:
Journal of Analytical Toxicology. 37:326-336
There is evidence that the endocrine systems of certain fish and wildlife can be affected by chemical contaminants, possibly resulting in developmental and reproductive problems. Perturbations in the hypothalamus-pituitary-thyroid (HPT) axis, in part
Autor:
Jane Chen Chuang, Paul Connolly, Martina Wimber, John M. Waechter, Stephen Dimond, Ronald N. Shiotsuka, Steven Hentges, Anne H. Chappelle, Narayana Rao, Dan A. Markham
Publikováno v:
Journal of Analytical Toxicology. 34:293-303
Bisphenol A (BPA) is an industrial chemical used to make polymers including some used in food contact applications. Virtually complete presystemic clearance of orally administered BPA occurs in humans by metabolism to BPA-glucuronide (BPA-G), but som
Autor:
James E. Hitt, Shakil A. Saghir, Brian D. Scherzer, Dan A. Markham, Gary B. Kupperblatt, Jonathan C. Evans, Edmund J. Elder
Publikováno v:
Drug Development and Industrial Pharmacy. 33:755-765
Many new molecular entities targeted for pharmaceutical applications face serious development challenges because of poor water solubility. Although particle engineering technologies such as controlled precipitation have been shown to enhance aqueous
Publikováno v:
Regulatory Toxicology and Pharmacology. 43:10-18
To determine potential nitrosation of triethanolamine (TEA) to N-nitrosodiethanolamine (NDELA) at different physiological conditions of the GI tract, in vitro NDELA formation was examined in aqueous reaction mixtures at several pHs (2-10) adjusted wi
Autor:
Lynn H. Pottenger, R. N. Shiotsuka, M. D. Dryzga, John M. Waechter, J. Y. Domoradzki, C. M. Thornton, T. L. Card, Steven C. Hansen, Dan A. Markham
Publikováno v:
Toxicological Sciences. 76:21-34
The pharmacokinetics of bisphenol A (BPA), including the quantification of the major BPA metabolite BPA-monoglucuronide conjugate (BPA-glucuronide) was studied in Sprague-Dawley rats at different stages of gestation. 14C-BPA was administered orally a
Autor:
Debra A. McNett, Charles A. Staples, Gary M. Klecka, Michael J. Bartels, Jenny H. Birk, Dan A. Markham
Publikováno v:
International Journal of Environmental Analytical Chemistry. 69:83-98
A sensitive and selective method is described for the simultaneous quantitation and confirmation of bisphenol-A (BPA) in river water to support a surface water analysis study. The method employs a cool-on-column injection, gas chromatographic separat
Autor:
Paul Lewer, Jeffrie A. Godbey, David McCaskill, Jeffrey R. Gilbert, Kathy A. Brzak, Bill Winniford, Vyacheslav N. Fishman, Olujide Akinbo, Sheher B. Mohsin, Michael J. Bartels, Dan A. Markham
Gas chromatography/mass spectrometry (GC/MS) can be applied to solve a wide range of problems in industrial research and development (R&D), ultimately contributing to the discovery, development, registration, and stewardship of new products. The abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1ba7f4fedf0cdfa2bbe8b705cdff1fc
https://doi.org/10.1016/b978-0-444-62623-3.00017-4
https://doi.org/10.1016/b978-0-444-62623-3.00017-4
Publikováno v:
Toxicology mechanisms and methods. 17(1)
Bisphenol A (BPA) (CAS Number 80-05-7; EINECS Number 201-245-8) is used in the production of plastics having food contact applications. Some biomonitoring studies have reported free BPA in blood or urine of humans. Since complete first-pass metabolis