Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Dan, Lindholm"'
Autor:
Miriana Scordino, Polina Stepanova, Vignesh Srinivasan, Dan Duc Pham, Ove Eriksson, Maciej Lalowski, Giuseppa Mudò, Valentina Di Liberto, Laura Korhonen, Merja H. Voutilainen, Dan Lindholm
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Canopy Homolog 2 (CNPY2) is an endoplasmic reticulum (ER) localized protein belonging to the CNPY gene family. We show here that CNPY2 is protective against ER stress induced by tunicamycin in neuronal cells. Overexpression of CNPY2 enhanced, while d
Externí odkaz:
https://doaj.org/article/ad182b23cb674e5c97b4ce7f571e0886
Autor:
Laura Korhonen, Elisabeth R. Paul, Karin Wåhlén, Liina Haring, Eero Vasar, Antti Vaheri, Dan Lindholm
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Immune cells and cytokines are largely recognized as significant factors in the pathophysiology of neuropsychiatric disorders. The possible role of other blood cells such as leukocytes in events of acute psychosis is in contrast only emergin
Externí odkaz:
https://doaj.org/article/946753e4940d4deb9689f2ea828bc968
Autor:
Mariliis Jaago, Annika Rähni, Nadežda Pupina, Arno Pihlak, Helle Sadam, Jürgen Tuvikene, Annela Avarlaid, Anu Planken, Margus Planken, Liina Haring, Eero Vasar, Miljana Baćević, France Lambert, Eija Kalso, Pirkko Pussinen, Pentti J. Tienari, Antti Vaheri, Dan Lindholm, Tõnis Timmusk, Amir M. Ghaemmaghami, Kaia Palm
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Immunity to previously encountered viruses can alter response to unrelated pathogens. We reasoned that similar mechanism may also involve SARS-CoV-2 and thereby affect the specificity and the quality of the immune response against the virus.
Externí odkaz:
https://doaj.org/article/616c68ebb3e24ae7b8bf2a3ef464fb1f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
USP14 is a deubiquitinating enzyme involved in protein degradation by interacting with the proteasome and removal of poly-ubiquitin chains on target proteins. USP14 can influence cellular processes such as cell survival, DNA repair, ER stress, endocy
Externí odkaz:
https://doaj.org/article/61ae4d4449044dbb829b78cf4730d8e4
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-15 (2022)
Abstract Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by gradual loss of memory and cognitive function, which constitutes a heavy burden on the healthcare system globally. Current therapeutics to interfere with
Externí odkaz:
https://doaj.org/article/cb41cb5553e6410fb7d8a0e5e0a047de
Autor:
Nadežda Pupina, Annela Avarlaid, Helle Sadam, Arno Pihlak, Mariliis Jaago, Jürgen Tuvikene, Annika Rähni, Anu Planken, Margus Planken, Eija Kalso, Pentti J. Tienari, Janne K. Nieminen, Mikko R.J. Seppänen, Antti Vaheri, Dan Lindholm, Juha Sinisalo, Pirkko Pussinen, Tõnis Timmusk, Kaia Palm
Publikováno v:
EBioMedicine, Vol 76, Iss , Pp 103835- (2022)
Summary: Background: Major cardiac events including myocardial infarction (MI) are associated with viral infections. However, how specific infections contribute to the cardiovascular insults has remained largely unclear. Methods: We employed next gen
Externí odkaz:
https://doaj.org/article/dda284cb78ec415f84eac3b3de69df35
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic with severe consequences for afflicted individuals and the society as a whole. The biology and infectivity of the virus has been intensively studied in
Externí odkaz:
https://doaj.org/article/49be7dd3bdf042158603072d15e1c678
Autor:
Taavi Vanaveski, Svetlana Molchanova, Dan Duc Pham, Annika Schäfer, Ceren Pajanoja, Jane Narvik, Vignesh Srinivasan, Mari Urb, Maria Koivisto, Eero Vasar, Tönis Timmusk, Rimante Minkeviciene, Ove Eriksson, Maciej Lalowski, Tomi Taira, Laura Korhonen, Vootele Voikar, Dan Lindholm
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a master regulator of mitochondria biogenesis and cell stress playing a role in metabolic and degenerative diseases. In the brain PGC-1α expression has been localized mainly
Externí odkaz:
https://doaj.org/article/fdada070cc85456ca0a0bfd453ceb7f0
Publikováno v:
Cells, Vol 11, Iss 10, p 1703 (2022)
LACTB is a relatively unknown mitochondrial protein structurally related to the bacterial penicillin-binding and beta-lactamase superfamily of serine proteases. LACTB has recently gained an increased interest due to its potential role in lipid metabo
Externí odkaz:
https://doaj.org/article/9c250afdace143eeb049119d50310ab6
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Neurons are polarized in structure with a cytoplasmic compartment extending into dendrites and a long axon that terminates at the synapse. The high level of compartmentalization imposes specific challenges for protein quality control in neurons makin
Externí odkaz:
https://doaj.org/article/e9bb2f88896044b78dad283a091ca49e