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Akademický článek

Circulating Galectin-3: A Prognostic Biomarker in Hepatocellular Carcinoma

Autor: Shadi Chamseddine, Betul Gok Yavuz, Yehia I. Mohamed, Sunyoung S. Lee, James C. Yao, Zishuo Ian Hu, Michael LaPelusa, Lianchun Xiao, Ryan Sun, Jeffrey S. Morris, Rikita I. Hatia, Manal Hassan, Dan G. Duda, Maria Diab, Amr Mohamed, Ahmed Nassar, Hesham M. Amin, Ahmed Omar Kaseb

Publikováno v: Journal of Immunotherapy and Precision Oncology, Vol 7, Iss 4, Pp 255-262 (2024)

Introduction: Galectin-3 plays critical roles in the adhesion, proliferation, and differentiation of tumor cells. Recent data have suggested that galectin-3 plays a role in the development of hepatocellular carcinoma (HCC); however, its prognostic va

Externí odkaz: https://doaj.org/article/c7007e3fd8d74d43a19828dfc72d4de2

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Akademický článek

Translational modeling-based evidence for enhanced efficacy of standard-of-care drugs in combination with anti-microRNA-155 in non-small-cell lung cancer

Autor: Prashant Dogra, Vrushaly Shinglot, Javier Ruiz-Ramírez, Joseph Cave, Joseph D. Butner, Carmine Schiavone, Dan G. Duda, Ahmed O. Kaseb, Caroline Chung, Eugene J. Koay, Vittorio Cristini, Bulent Ozpolat, George A. Calin, Zhihui Wang

Publikováno v: Molecular Cancer, Vol 23, Iss 1, Pp 1-19 (2024)

Abstract Background Elevated microRNA-155 (miR-155) expression in non-small-cell lung cancer (NSCLC) promotes cisplatin resistance and negatively impacts treatment outcomes. However, miR-155 can also boost anti-tumor immunity by suppressing PD-L1 exp

Externí odkaz: https://doaj.org/article/f5c916f279b74e3c88a10c02785cb0e7

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Akademický článek

Metabolic gene therapy in a canine with pulmonary hypertension secondary to degenerative mitral valve disease

Autor: Michael G. Katz, Dan G. Ohad, Philip Putter, Nataly Shtraizent, Ehud Shahar, Smadar Tal, Efrat Eliyahu

Publikováno v: Frontiers in Veterinary Science, Vol 11 (2024)

Myxomatous mitral valve disease (MMVD) stands out as the most prevalent acquired canine heart disease. Its occurrence can reach up to 40% in small breed dogs and escalates in geriatric canine populations. MMVD leads to thickening and incomplete coapt

Externí odkaz: https://doaj.org/article/cedc944a485643aeaec9e857f2e60a10

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Akademický článek

Exploring Histoplasma species seroprevalence and risk factors for seropositivity in The Gambia’s working equid population: Baseline analysis of the Tackling Histoplasmosis project dataset

Autor: Tessa Rose Cornell, Biram Laity Fye, Edrisa Nyassi, Fatou Ceesay, Mahmud Jallow, R. Frèdi Langendonk, Dan G. Wootton, Gina Pinchbeck, Claire Elizabeth Scantlebury

Publikováno v: Frontiers in Veterinary Science, Vol 11 (2024)

IntroductionExposure rates to Histoplasma species, the causative agent of equine epizootic lymphangitis (EL), are unknown amongst working equids in The Gambia. The primary aims of this study were to estimate anti-Histoplasma antibody seroprevalence i

Externí odkaz: https://doaj.org/article/05ce169f9b4745aab74299065ac031de

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Akademický článek

HAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE® FILM ARRAY® pneumonia plus panel in adults with suspected non-ventilator-associated hospital-acquired pneumonia

Autor: Bridget Young, Lance Turtle, Stephen Aston, Ashley P Jones, Alex Howard, Dan G Wootton, Stephanie Willshaw, Frances Sherratt, Natalia Shafiqa, Simon Abrams, Anica Alvarez Nishio

Publikováno v: BMJ Open, Vol 14, Iss 7 (2024)

Introduction Non-ventilator-associated hospital-acquired pneumonia (nv-HAP) is the most common healthcare-associated infection (HCAI), is associated with high mortality and morbidity and places a major burden on healthcare systems. Diagnosis currentl

Externí odkaz: https://doaj.org/article/249b963ef12f40d38d2c2c257122b294

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Akademický článek

Histoplasma seropositivity and environmental risk factors for exposure in a general population in Upper River Region, The Gambia: A cross-sectional study

Autor: Tessa Rose Cornell, Bakary Conteh, Lamin Drammeh, Foday Jeffang, Ebrima Sallah, Alkali Kijera, Mustapha Jarju, Mehrab Karim, Ebrima Khan, Pa Ousman Ceesay, Ebrima Manneh, Dan G. Wootton, Gina Pinchbeck, Claire Elizabeth Scantlebury

Publikováno v: One Health, Vol 18, Iss , Pp 100717- (2024)

Robust surveillance of Histoplasma species is warranted in endemic regions, including investigation of community-level transmission dynamics. This cross-sectional study explored anti-Histoplasma antibody seroprevalence and risk factors for exposure i

Externí odkaz: https://doaj.org/article/8ffef110334d4265b069070156a895b4

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Akademický článek

Demography, common disorders and mortality of Shih Tzu dogs under primary veterinary care in the UK

Autor: Fiona Dale, Dave C. Brodbelt, Gabriella West, David B. Church, Yan Hui Lee, Dan G. O’Neill

Publikováno v: Canine Medicine and Genetics, Vol 11, Iss 1, Pp 1-16 (2024)

Abstract Background Shih Tzus are a popular dog breed in the UK although there is relatively little reported information on their health. This study aimed to characterise the demography, common disorders and mortality of Shih Tzus under primary veter

Externí odkaz: https://doaj.org/article/657d6c33d0c3436bb75e64d9ee6250eb

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Akademický článek

English Cocker Spaniels under primary veterinary care in the UK: disorder predispositions and protections

Autor: Karolina S. Engdahl, Dave C. Brodbelt, Carla Cameron, David B. Church, Dan G. O’Neill

Publikováno v: Canine Medicine and Genetics, Vol 11, Iss 1, Pp 1-13 (2024)

Abstract Background The English Cocker Spaniel (ECS) is one of the most popular dog breeds in the UK but information on disorder predisposition and protection is limited. Using anonymised veterinary clinical data from the VetCompass™ Programme, thi

Externí odkaz: https://doaj.org/article/83bc81bba74e42f794022c1ebd9991a2

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Akademický článek

Is it now time to iron out the wrinkles? Health of Shar Pei dogs under primary veterinary care in the UK

Autor: Dan G. O’Neill, Karolina S. Engdahl, Alice Leach, Rowena M. A. Packer, David B. Church, Dave C. Brodbelt

Publikováno v: Canine Medicine and Genetics, Vol 10, Iss 1, Pp 1-14 (2023)

Abstract Background The Shar Pei is a common dog breed with a distinctive appearance caused by hyaluronosis that has been linked with several health conditions. Anonymised primary-care veterinary clinical records were explored to extract data on the

Externí odkaz: https://doaj.org/article/179e555826cb47b7ab34863594bc8204

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