Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Damon R. Asher"'
Autor:
Natalie L. Goedeker, Sachi D. Dharia, Danielle A. Griffin, Jesantha Coy, Todd Truesdale, Rajan Parikh, Kasen Whitehouse, Sourav Santra, Damon R. Asher, Craig M. Zaidman
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 16 (2023)
Background: Adeno-associated virus (AAV) vectors are a promising platform for in vivo transfer of transgenes designed to treat diseases. Pre-existing humoral immunity to these vectors can potentially impact the safety and efficacy of gene therapies.
Externí odkaz:
https://doaj.org/article/3188b9979c4a41868a6b7e86441ae1d1
Autor:
Jerry R. Mendell, Louise R. Rodino-Klapac, Navid Z. Khan, Damon R. Asher, Khampaseuth Thapa, Sachi D. Dharia, Rachael A. Potter
Publikováno v:
Expert Opinion on Biological Therapy. 20:263-274
Introduction: The development of adeno-associated virus (AAV) vectors as safe vehicles for in vivo delivery of therapeutic genes has been a major milestone in the advancement of gene therapy, enabl...
Autor:
Kwok-Shun Cheng, Senthilkumar Ramaswamy, Ushma Mehta, Franklin Chung, Damon R. Asher, Nakry Sisowath, Ganesh Iyer, Anne Leahy
Publikováno v:
Procedia in Vaccinology. 6:106-112
A two step flow-through chromatography process is proposed as an universal approach to purify viruses. A resin column with reduced surface area was developed for the first step to remove bulk of the host cell protein (HCP) from a viral feed stream wh
Publikováno v:
The Journal of Immunology. 178:3363-3367
TLR7 recognizes the genome of ssRNA viruses such as Coxsackievirus B. Because TLR7 is expressed in intracellular compartments, viral RNA must be internalized before its recognition by TLR7. In this study, we define plasmacytoid dendritic cells (pDC)
Autor:
Damon R. Asher, Michael McGlothlen
Publikováno v:
Genetic Engineering & Biotechnology News. 36:28-29
Autor:
Kwok-Shun Cheng, Ganesh Iyer, Senthilkumar Ramaswamy, Ushma Mehta, Damon R. Asher, Franklin Chung, Anne Leahy
Publikováno v:
Journal of chromatography. A. 1218(26)
A method for flow-through purification of viruses and virus like nano-particles using a combination of binding and size-exclusion chromatography was developed. This technique relies on minimizing the external surface area per unit volume available fo
Autor:
Evelyn A. Kurt-Jones, Robert W. Finberg, Anna M. Cerny, Jennifer P. Wang, Damon R. Asher, Roderick T. Bronson
Coxsackie B viruses (CVB) are enteroviruses that have been associated with a variety of human diseases, including myocarditis. In the present study, we found that MDA5 and its adaptor molecule MAVS are critical for type I interferon responses to CVB,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75db66282937966d6aef44ec14ff380
https://europepmc.org/articles/PMC2798442/
https://europepmc.org/articles/PMC2798442/
Autor:
James W. Horner, Robert W. Finberg, Roderick T. Bronson, Anna M. Cerny, Ronald A. DePinho, Damon R. Asher, Marilyn L. Keeler, Stephen N. Jones, Mychell A. Neptune, Sarah R. Weiler
Publikováno v:
Genesis (New York, N.Y. : 2000). 42(2)
The coxsackievirus and adenovirus receptor (CAR) is a transmembrane protein that is known to be a site of viral attachment and entry, but its physiologic functions are undefined. CAR expression is maximal in neonates and wanes rapidly after birth in
Autor:
Stephen N. Jones, Anna M. Cerny, Nehal Mohamed, Robert W. Finberg, Anne Nicholson-Weller, Leslie S. Casey, Steven M. Jones, Alexander Repik, Steve E. Pincus, Lloyd B. Klickstein, Damon R. Asher, George L. Spitalny, Ionita Ghiran
Publikováno v:
Clinical and experimental immunology. 140(2)
Summary Complement receptor 1 (CR1) on the surface of human erythrocytes facilitates intravascular clearance of complement-opsonized pathogens. The need for complement activation can be circumvented by directly coupling the organism to CR1 using a bi
Publikováno v:
Genetic Engineering & Biotechnology News. 33:36-37