Zobrazeno 1 - 10 of 180 pro vyhledávání: '"Damon R Reed"'
1
Akademický článek
The genomic landscape of undifferentiated embryonal sarcoma of the liver is typified by C19MC structural rearrangement and overexpression combined with TP53 mutation or loss.
Autor: Bhuvana A Setty, Goodwin G Jinesh, Michael Arnold, Fredrik Pettersson, Chia-Ho Cheng, Ling Cen, Sean J Yoder, Jamie K Teer, Elsa R Flores, Damon R Reed, Andrew S Brohl
Publikováno v: PLoS Genetics, Vol 16, Iss 4, p e1008642 (2020)
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare and aggressive malignancy. Though the molecular underpinnings of this cancer have been largely unexplored, recurrent chromosomal breakpoints affecting a noncoding region on chr19q13, wh
Externí odkaz: https://doaj.org/article/b6589845a4374b11a2aa4db4bf36bd21
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2
Akademický článek
Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines.
Autor: Darcy Welch, Elliot Kahen, Brooke Fridley, Andrew S Brohl, Christopher L Cubitt, Damon R Reed
Publikováno v: PLoS ONE, Vol 14, Iss 9, p e0222228 (2019)
Ewing Sarcoma (ES) is characterized by recurrent translocations between EWSR1 and members of the ETS family of transcription factors. The transcriptional activity of the fusion oncoprotein is dependent on interaction with the nucleosome remodeling an
Externí odkaz: https://doaj.org/article/c3bbc978931f43f881e091e9cd886658
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3
Akademický článek
Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy
Autor: Darcy L. Welch, Brooke L. Fridley, Ling Cen, Jamie K. Teer, Sean J. Yoder, Fredrik Pettersson, Liping Xu, Chia-Ho Cheng, Yonghong Zhang, Mark G. Alexandrow, Shengyan Xiang, Mark Robertson-Tessi, Joel S. Brown, Jonathan Metts, Andrew S. Brohl, Damon R. Reed
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Osteosarcoma is the most common bone sarcoma in children and young adults. While universally delivered, chemotherapy only benefits roughly half of patients with localized disease. Increasingly, intratumoral heterogeneity is recognized as a s
Externí odkaz: https://doaj.org/article/f7513fb0926f4a94b84dd06a5b81bbee
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4
Akademický článek
AI-Radiomics Can Improve Inclusion Criteria and Clinical Trial Performance
Autor: Michal R. Tomaszewski, Shuxuan Fan, Alberto Garcia, Jin Qi, Youngchul Kim, Robert A. Gatenby, Matthew B. Schabath, William D. Tap, Denise K. Reinke, Rikesh J. Makanji, Damon R. Reed, Robert J. Gillies
Publikováno v: Tomography, Vol 8, Iss 1, Pp 341-355 (2022)
Purpose: Success of clinical trials increasingly relies on effective selection of the target patient populations. We hypothesize that computational analysis of pre-accrual imaging data can be used for patient enrichment to better identify patients wh
Externí odkaz: https://doaj.org/article/b7bfcc234f824a8f824df183331d4c45
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7
Akademický článek
Higher than reported adolescent and young adult clinical trial enrollment during the 'Golden Age' of melanoma clinical trials
Autor: Radhika Sreeraman Kumar, Ram Thapa, Youngchul Kim, Nikhil I. Khushalani, Vernon K. Sondak, Damon R. Reed
Publikováno v: Cancer Medicine, Vol 7, Iss 4, Pp 991-996 (2018)
Abstract Clinical trial enrollments in adolescents and young adults (AYA) with cancer have historically been lower than those in pediatric and older adult populations. We sought to examine therapeutic trial enrollment rates at our cancer center. We p
Externí odkaz: https://doaj.org/article/8df41a25b5f9455dbc1e6fb507667feb
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9
Akademický článek
Myoepithelial carcinoma with RB1 mutation: remarkable chemosensitivity to carcinoma of unknown origin therapy
Autor: Timothy M. Hoggard, Evita Henderson-Jackson, Marilyn M. Bui, Jamie Caracciolo, Jamie K. Teer, Sean Yoder, Odion Binitie, Ricardo J. Gonzalez, Andrew S. Brohl, Damon R. Reed
Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-6 (2017)
Abstract Background Myoepithelial carcinoma of soft tissue is a rare, malignant neoplasm that is morphologically and immunophenotypically similar to its counterpart in salivary gland. It demonstrates myoepithelial differentiation, possessing both epi
Externí odkaz: https://doaj.org/article/5a6b35b18ba1432d908b9e27d7c3b994
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