Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Damon Poburko"'
Autor:
Thomas W. Claydon, Glen F. Tibbits, Eric Lin, Diana Hunter, Yen May Cheng, Damon Poburko, Raj Johal, Mandy Yip, Ravichandra Venkateshappa, Shoaib Faizi, Kyle E. Simpson
Publikováno v:
Journal of visualized experiments : JoVE. (187)
Clustered regularly interspaced short palindromic repeats (CRISPR) in animal models enable precise genetic manipulation for the study of physiological phenomena. Zebrafish have been used as an effective genetic model to study numerous questions relat
Publikováno v:
Biophysical Journal. 122:399a
Autor:
Darwin F. Yeung, Anna Lehman, Dayna-Lynn Nevay, Teresa S.M. Tsang, Damon Poburko, Michael Tsang, Dana Young, Michelle M. Mezei, Andrew D. Pauls, Vikrant Sandhu, Sandra Sirrs
Publikováno v:
Mitochondrion. 53:194-202
Animal studies suggest that decreased vascular mitochondrial DNA copy number can promote hypertension. We conducted a chart review of blood pressure and hemodynamics in patients with either mitochondrial encephalopathy, lactic acidosis, and stroke-li
Autor:
Colin H. Peters, Damon Poburko, Peter C. Ruben, Elise Brimble, Emily M. Spelbrink, Madeline Angus
Publikováno v:
Journal of Neurophysiology. 122:1975-1980
Dravet syndrome is a severe form of childhood epilepsy characterized by frequent temperature-sensitive seizures and delays in cognitive development. In the majority (80%) of cases, Dravet syndrome is caused by mutations in the SCN1A gene, encoding th
Autor:
Cynthia Gershome, BaRun Kim, Damon Poburko, Nickolas Saraev, Jagdeep Singh Walia, Somayeh Mojarad Kalkhoran, Sarah Heather Jane Chow
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 316:H89-H105
ATP and norepinephrine (NE) are coreleased from peripheral sympathetic nerve terminals. Whether they are stored in the same vesicles has been debated for decades. Preferential dependence of NE or ATP release on Ca2+ influx through specific voltage-ga
Publikováno v:
Pharmacologytherapeutics. 232
The past thirty years have seen a surge in interest in pathophysiological roles of mitochondria, and the accurate quantification of mitochondrial DNA copy number (mCN) in cells and tissue samples is a fundamental aspect of assessing changes in mitoch
Autor:
Tagore S. Bandaru, Lucie Delemotte, Mohammad-Reza Ghovanloo, Olaf S. Andersen, Karen Nelkenbrecher, Jenifer Thewalt, Koushik Choudhury, Mohamed A. Fouda, Kaveh Rayani, Peter C. Ruben, Samuel J. Goodchild, Radda Rusinova, Damon Poburko, Tejas Phaterpekar, Abeline R. Watkins
Publikováno v:
The Journal of General Physiology
Ghovanloo et al. combined in silico and in vitro approaches to determine the mechanism by which CBD inhibits the skeletal muscle Na+ channel Nav1.4. Their findings suggest that CBD acts directly, by binding inside the Nav1.4 pore, as well as indirect
Publikováno v:
Cell calcium. 96
Vascular smooth muscle cells are unusual in that differentiated, contractile cells possess the capacity to "de-differentiate" into a synthetic phenotype that is characterized by being replicative, secretory, and migratory. One aspect of this phenotyp
Autor:
Radda Rusinova, Damon Poburko, Karen Nelkenbrecher, Mohamed A. Fouda, Jenifer Thewalt, Samuel J. Goodchild, Koushik Choudhury, Olaf S. Andersen, Kaveh Rayani, Abeline R. Watkins, Tejas Phaterpekar, Mohammad-Reza Ghovanloo, Tagore S. Bandaru, Lucie Delemotte, Peter C. Ruben
Cannabis sativa contains active constituents called phytocannabinoids. Some phytocannabinoids are psychotropic and others are not. The primary non-psychotropic phytocannabinoid is cannabidiol (CBD), which is proposed to be therapeutic against many co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::492ceb9e6fa1253e1919317a38d39a16
https://doi.org/10.1101/2020.06.30.180943
https://doi.org/10.1101/2020.06.30.180943
Publikováno v:
Cell Calcium. 96:102369
Vascular smooth muscle cells are unusual in that differentiated, contractile cells possess the capacity to “de-differentiate” into a synthetic phenotype that is characterized by being replicative, secretory, and migratory. One aspect of this phen