Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Damon L. Meyer"'
Autor:
Alain Nicolas, Paula Gonçalves Cerqueira, Monique Chavez, Sophie Loeillet, Wolf Dietrich Heyer, Becky Xu Hua Fu, Damon L. Meyer
Publikováno v:
DNA Repair. 76:40-49
DNA polymerases influence genome stability through their involvement in DNA replication, response to DNA damage, and DNA repair processes. Saccharomyces cerevisiae possess four non-essential DNA polymerases, Pol λ, Pol η, Pol ζ, and Rev1, which ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f87896566924c5063c5e12e770969fa
https://doi.org/10.1016/j.dnarep.2019.02.004
https://doi.org/10.1016/j.dnarep.2019.02.004
Autor:
Wolf Dietrich Heyer, Aurèle Piazza, Becky Xu Hua Fu, Kevin Yan, Shih-Hsun Hung, Erin K. Schwartz, Damon L. Meyer
Publikováno v:
PLoS Genetics
PLoS Genetics, 2020, 16 (5), pp.e1008816. ⟨10.1371/journal.pgen.1008816⟩
PLoS Genetics, Public Library of Science, 2020, 16 (5), pp.e1008816. ⟨10.1371/journal.pgen.1008816⟩
PLoS genetics, vol 16, iss 5
PLoS Genetics, Vol 16, Iss 5, p e1008816 (2020)
PLoS Genetics, 2020, 16 (5), pp.e1008816. ⟨10.1371/journal.pgen.1008816⟩
PLoS Genetics, Public Library of Science, 2020, 16 (5), pp.e1008816. ⟨10.1371/journal.pgen.1008816⟩
PLoS genetics, vol 16, iss 5
PLoS Genetics, Vol 16, Iss 5, p e1008816 (2020)
Alternative lengthening of telomeres (ALT) in human cells is a conserved process that is often activated in telomerase-deficient human cancers. This process exploits components of the recombination machinery to extend telomere ends, thus allowing for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f909d83245fa22ed8072eaf0fa8330
https://hal.science/hal-02999779
https://hal.science/hal-02999779
Autor:
Damon L. Meyer, Mitch McVey, Wolf Dietrich Heyer, Paula Gonçalves Cerqueira, Varandt Y. Khodaverdian
Publikováno v:
Annual review of genetics, vol 50, iss 1
Homologous recombination (HR) is a central process to ensure genomic stability in somatic cells and during meiosis. HR-associated DNA synthesis determines in large part the fidelity of the process. A number of recent studies have demonstrated that DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05cafbf5edc7514602a9f6573801206
https://europepmc.org/articles/PMC5295669/
https://europepmc.org/articles/PMC5295669/
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 112, iss 50
Maintenance of genome stability is carried out by a suite of DNA repair pathways that ensure the repair of damaged DNA and faithful replication of the genome. Of particular importance are the repair pathways, which respond to DNA double-strand breaks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15d91f14a57cbf0252b4c88c0ff517a
https://escholarship.org/uc/item/2vm6z0z4
https://escholarship.org/uc/item/2vm6z0z4
Autor:
John Gooya, Sudha Swamynathan, Changshou Gao, Michael S. Kinch, Linda Xu, Margarita Camara, Damon L. Meyer, Steven Coats, Peter A. Kiener, Peter D. Senter, Ryan Fleming, Herren Wu, David A. Tice, Christine Fazenbaker, Krista Kinneer, Shenlan Mao, Dowdy Jackson
Publikováno v:
Cancer Research. 68:9367-9374
The EphA2 receptor tyrosine kinase is selectively expressed on the surface of many different human tumors. We have previously shown that tumor cells can be targeted by EphA2 monoclonal antibodies and that these antibodies function, in part, by induci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfb0e5f4892903fd25ec2c813706510
https://doi.org/10.1158/0008-5472.can-08-1933
https://doi.org/10.1158/0008-5472.can-08-1933
Autor:
Russell J. Sanderson, Scott C. Jeffrey, Peter D. Senter, Nicole M. Okeley, Stephen C. Alley, Damon L. Meyer, Dennis Benjamin
Publikováno v:
Bioconjugate Chemistry. 19:759-765
The linker component of antibody-drug conjugates (ADC) is a key feature in developing optimized therapeutic agents that are highly active at well tolerated doses. For maximal intratumoral drug delivery, linkers are required that are highly stable in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471b1d78e044ec2a9222b931cb56fda1
https://doi.org/10.1021/bc7004329
https://doi.org/10.1021/bc7004329
Autor:
Charlotte Mcdonagh, Maureen Ryan, Paul Carter, Iqbal S. Grewal, David Peckham, Michelle A. Hering, Lindsay L. Brown, Damon L. Meyer, Kristine M. Kim, Roger F. Zabinski
Publikováno v:
Molecular Cancer Therapeutics. 6:3009-3018
B-cell maturation antigen (BCMA) is expressed on normal and malignant plasma cells and represents a potential target for therapeutic intervention. BCMA binds to two ligands that promote tumor cell survival, a proliferation inducing ligand (APRIL) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ecedacfb50baa13ef47c78212e627a
https://doi.org/10.1158/1535-7163.mct-07-0464
https://doi.org/10.1158/1535-7163.mct-07-0464
Autor:
Robbert J. Kok, Grietje Molema, Kai Temming, Damon L. Meyer, Klaas Poelstra, Eli C. F. Dijkers, Roger F. Zabinski
Publikováno v:
BIOCONJUGATE CHEMISTRY, 17(6), 1385-1394. AMER CHEMICAL SOC
Induction of apoptosis in endothelial cells is considered an attractive strategy to therapeutically interfere with a solid tumor's blood supply. In the present paper, we constructed cytotoxic conjugates that specifically target angiogenic endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8029907ff91d8d65c1e3f8dbfd02c25a
https://doi.org/10.1021/bc060087z
https://doi.org/10.1021/bc060087z
Autor:
Scott C. Jeffrey, Damon L. Meyer, Minh T. Nguyen, Svetlana O. Doronina, Jamie B. Andreyka, Peter D. Senter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:358-362
Highly potent and novel derivatives of doxorubicin were linked to monoclonal antibodies (mAbs) for site-specific drug delivery. Drug linker 5 consisted of a dipeptide linker attached directly to the daunosamine nitrogen of the n-butyldiacetate doxoru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3742d2cd81bd472cc777d8d18d093d
https://doi.org/10.1016/j.bmcl.2005.09.081
https://doi.org/10.1016/j.bmcl.2005.09.081
Autor:
Brian A. Mendelsohn, and Alan F. Wahl, Ezogelin Oflazoglu, Russell J. Sanderson, Brian E. Toki, Damon L. Meyer, Charles G. Cerveny, Stephen C. Alley, Roger F. Zabinski, Svetlana O. Doronina, Peter D. Senter, Tim D. Bovee
Publikováno v:
Bioconjugate Chemistry. 17:114-124
We have previously shown that antibody-drug conjugates (ADCs) consisting of cAC10 (anti-CD30) linked to the antimitotic agent monomethylauristatin E (MMAE) lead to potent in vitro and in vivo activities against antigen positive tumor models. MMAF is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::397fcfeadaeb9ffdf49cc7ceecaceac8
https://doi.org/10.1021/bc0502917
https://doi.org/10.1021/bc0502917