Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis

Autor: Beverley E. Minter, Damon A. Lowes, Nigel R. Webster, Helen F. Galley

Publikováno v: Antioxidants, Vol 9, Iss 3, p 195 (2020)

Sepsis is a life-threatening response to infection associated with inflammation, oxidative stress and mitochondrial dysfunction. We investigated differential effects of three forms of vitamin E, which accumulate in different cellular compartments, on

Externí odkaz: https://doaj.org/article/59706ba4d2c34bc2a0b263dcac24f78c

MitoVitE, a mitochondria-targeted antioxidant, limits paclitaxel-induced oxidative stress and mitochondrial damage in vitro, and paclitaxel-induced mechanical hypersensitivity in a rat pain model

Autor: Carole Torsney, Helen F. Galley, Barry McCormick, Damon A. Lowes, Lesley Colvin

Publikováno v: Mccormick, B, Lowes, D, Colvin, L, Torsney, C & Galley, H 2016, ' MitoVitE, a mitochondria-targeted antioxidant, limits paclitaxel-induced oxidative stress and mitochondrial damage in vitro, and paclitaxel-induced mechanical hypersensitivity in a rat pain model. ', British Journal of Anaesthesia . https://doi.org/10.1093/bja/aew309

Neuropathic pain is a common side-effect of chemotherapy. Although precise mechanisms are unclear, oxidative stress and mitochondrial damage are involved. We investigated whether the mitochondria targeted antioxidant, MitoVitE, provided better protec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925b11aceb5dc485c95dc858682d1597
https://doi.org/10.1093/bja/aew309

Abstracts of the Winter Anaesthetic Research Society Meeting (ARS)

Autor: F. Koumpa, Joyce Yeung, S. Savage, T. G. Hales, Hailin Zhao, Damon A. Lowes, J. Shi, T. Jaffer, L. Hammon, D. Z. Wu, J. Cui, D. Fiszer, S. Handa, P. Sarkar, H. Galley, R. Marks, D. T. Baptista-Hon, L. Gardner, T. Elajnef, Philip M. Hopkins, C. Wang, T. Li, R. Sabbagh, D. Roiz de Sa, Marie-Anne Shaw, I.J. Wrench, C. J. Weir, Q. G. Ye, J. Sun, I. A. Maltman, B. Gray, Fang Gao, Daqing Ma, Qingquan Lian, A. Date, Ravi Mahajan, Nigel R. Webster

Publikováno v: British Journal of Anaesthesia. 114:1015-1024

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ddaebd66f6ee5556a8edc5010cc8643
https://doi.org/10.1093/bja/aeu367

Brief isoflurane anaesthesia affects differential gene expression, gene ontology and gene networks in rat brain

Autor: Helen F. Galley, Damon A. Lowes, Nigel R. Webster, Alessandro P. S. de Moura

Publikováno v: Behavioural brain research. 317

Much is still unknown about the mechanisms of effects of even brief anaesthesia on the brain and previous studies have simply compared differential expression profiles with and without anaesthesia. We hypothesised that network analysis, in addition t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b8f2abc2b042b22e72e814696e5d61
https://pubmed.ncbi.nlm.nih.gov/27659556

Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis

Autor: Damon A. Lowes, V.L. Reid, A.M. Almawash, Nigel R. Webster, Helen F. Galley

Publikováno v: British Journal of Anaesthesia. 107:193-201

Background. Development of organ dysfunction associated with sepsis is due in part to oxidative damage to mitochondria. Melatonin regulates the sleep‐wake cycle and also has potent antioxidant activity. The aim of this study was to determine the ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89fcd3fc1d3e851685f6389a1b877bfd
https://doi.org/10.1093/bja/aer149