Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Damon A. Hofman"'
1
Akademický článek
Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine
Autor: Mireia Palomar-Siles, Angelos Heldin, Meiqiongzi Zhang, Charlotte Strandgren, Viktor Yurevych, Jip T. van Dinter, Sem A. G. Engels, Damon A. Hofman, Susanne Öhlin, Birthe Meineke, Vladimir J. N. Bykov, Sebastiaan van Heesch, Klas G. Wiman
Publikováno v: Cell Death and Disease, Vol 13, Iss 11, Pp 1-17 (2022)
Abstract TP53 nonsense mutations in cancer produce truncated inactive p53 protein. We show that 5-FU metabolite 5-Fluorouridine (FUr) induces full-length p53 in human tumor cells carrying R213X nonsense mutant TP53. Ribosome profiling visualized tran
Externí odkaz: https://doaj.org/article/d20df1692ffe43d69b4b2923e7b6b3b8
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2
Akademický článek
Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch
Autor: Judith Wienke, S Nierkens, Miranda P Dierselhuis, Jan J Molenaar, Annelisa M Cornel, Ester Dunnebach, Damon A Hofman, Sanjukta Das, Satyaki Sengupta, Femke van den Ham, Josephine G M Strijker, Denise A M H van den Beemt, Anke H W Essing, Bianca Koopmans, Sem A G Engels, Vania Lo Presti, Celina S Szanto, Rani E George, Sebastiaan van Heesch
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background Immunotherapy in high-risk neuroblastoma (HR-NBL) does not live up to its full potential due to inadequate (adaptive) immune engagement caused by the extensive immunomodulatory capacity of HR-NBL. We aimed to tackle one of the most notable
Externí odkaz: https://doaj.org/article/7142ba69053342a98bcc3622acf2b968
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6
Data from Mutation Signatures of Pediatric Acute Myeloid Leukemia and Normal Blood Progenitors Associated with Differential Patient Outcomes
Autor: Ruben van Boxtel, Mirjam E. Belderbos, Joske Ubels, Freek Manders, Mark Verheul, Rurika Oka, Damon A. Hofman, Markus J. van Roosmalen, Eline J.M. Bertrums, Arianne M. Brandsma
Acquisition of oncogenic mutations with age is believed to be rate limiting for carcinogenesis. However, the incidence of leukemia in children is higher than in young adults. Here we compare somatic mutations across pediatric acute myeloid leukemia (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691d34e613ed0a121287422ff56513f1
https://doi.org/10.1158/2643-3230.c.6550159
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7
Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch
Autor: Annelisa M Cornel, Ester Dunnebach, Damon A Hofman, Sanjukta Das, Satyaki Sengupta, Femke van den Ham, Judith Wienke, Josephine G M Strijker, Denise A M H van den Beemt, Anke H W Essing, Bianca Koopmans, Sem A G Engels, Vania Lo Presti, Celina S Szanto, Rani E George, Jan J Molenaar, Sebastiaan van Heesch, Miranda P Dierselhuis, S Nierkens
Publikováno v: Journal for ImmunoTherapy of Cancer. 10:e005002
BackgroundImmunotherapy in high-risk neuroblastoma (HR-NBL) does not live up to its full potential due to inadequate (adaptive) immune engagement caused by the extensive immunomodulatory capacity of HR-NBL. We aimed to tackle one of the most notable
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523204a6719fb30ea68604533c303a61
https://doi.org/10.1136/jitc-2022-005002
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