Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Damoder Reddy Motati"'
Publikováno v:
Organic Chemistry Frontiers. 8:466-513
The azaindole chemical scaffold is represented in many biologically active natural products and synthetic derivatives. Recently, this chemical scaffold yielded several therapeutic agents for a variety of diseases. Due to the interesting biochemical a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ef1930d37496bf44c62ab236e402461
https://doi.org/10.1039/d0qo01079k
https://doi.org/10.1039/d0qo01079k
Autor:
Thota Ganesh, Avijit Banik, Asheebo Rojas, Damoder Reddy Motati, Raymond Dingledine, Shabber Mohammed, Wenyi Wang, Radhika Amaradhi, Vidyavathi Patro
Publikováno v:
J Med Chem
Activation of prostanoid EP2 receptor exacerbates neuroinflammatory and neurodegenerative pathology in central nervous system diseases such as epilepsy, Alzheimer's disease, and cerebral aneurysms. A selective and brain-permeable EP2 antagonist will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1db3d0b0dccdda8e821c69f53ae2ab
https://doi.org/10.1021/acs.jmedchem.9b01218
https://doi.org/10.1021/acs.jmedchem.9b01218
Autor:
E. Blake Watkins, Amarender Goud Burra, Dilipkumar Uredi, Damoder Reddy Motati, J. Phillip Bowen, Frank R. Fronczek, Clint R. Smith
Publikováno v:
Organic Chemistry Frontiers. 7:1095-1106
A highly efficient, site-selective, visible light-accelerated, remote C–H halogenation of unsymmetrical aromatic bisamides/amidoesters has been developed. Unprecedented selectivity was realized in this C–H functionalization reaction. The N,N′-(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da19f36b126c8dadaa4f678ea8d8c840
https://doi.org/10.1039/c9qo01508f
https://doi.org/10.1039/c9qo01508f
Publikováno v:
Current Topics in Medicinal Chemistry. 19:1650-1675
Human immunodeficiency virus type-1 (HIV-1) is the causative agent responsible for the acquired immunodeficiency syndrome (AIDS) pandemic. More than 60 million infections and 25 million deaths have occurred since AIDS was first identified in the earl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f9652030f077f65c2398892cddbe2c
https://doi.org/10.2174/1568026619666190717163959
https://doi.org/10.2174/1568026619666190717163959
Publikováno v:
Chemical Communications. 55:3270-3273
A simple and modular one-step synthesis of diversely substituted pyridines from readily available α,β-unsaturated carbonyl compounds and propargylic amines has been developed. The present protocol has a broad substrate scope and allows access to mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c43a5f4562c005c10b2b2c43507580
https://doi.org/10.1039/c9cc01097a
https://doi.org/10.1039/c9cc01097a
Publikováno v:
Bioorg Med Chem
Azaindole structural framework is an integral part of several biologically active natural and synthetic organic molecules; and several FDA approved drugs for various diseases. In the last decade, quite a number of literature reports appeared describi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ce0e32b99cbd7e502a2ae964039d6d
https://europepmc.org/articles/PMC7736151/
https://europepmc.org/articles/PMC7736151/
Metal-catalyzed, bidentate directing group-assisted, C–H activation and functionalization have expanded exponentially in the past few years and provides numerous opportunities in the synthesis of a range of substrates in a straightforward and step-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe90187b1c0a48fb6e925546dfa117d7
https://doi.org/10.1016/b978-0-12-817901-7.00004-6
https://doi.org/10.1016/b978-0-12-817901-7.00004-6
Publikováno v:
Organic letters. 20(20)
An efficient, unified approach for the synthesis of β-carbolines, γ-carbolines, and other fused azaheteroaromatics has been realized under metal-free conditions, from propargylic amines and (hetero)aromatic aldehydes. This unified strategy provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86682eccdaf31dcde11c3e01be46e502
https://pubmed.ncbi.nlm.nih.gov/30272985
https://pubmed.ncbi.nlm.nih.gov/30272985
Publikováno v:
Journal of natural products. 81(6)
Nonenolide (1) was first isolated from the entomopathogenic fungus Cordyceps militaries BCC2816 and exhibited good antimalarial activity against Plasmodium falciparum K1. Structurally, it features a decanolide with a trans-double bond attached to two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e8a42488a18bc8bd47e55102e48d99
https://pubmed.ncbi.nlm.nih.gov/29889525
https://pubmed.ncbi.nlm.nih.gov/29889525
Publikováno v:
Chemical Science
An operationally simple, metal-free protocol for regioselective halogenation of a range of 8-substituted quinolines has been established using recyclable trihaloisocyanuric acids.
An operationally simple and metal-free protocol for geometrically
An operationally simple and metal-free protocol for geometrically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c12f27a868541bd58a83e7a2569e38
https://pubmed.ncbi.nlm.nih.gov/29675222
https://pubmed.ncbi.nlm.nih.gov/29675222