Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Damir Vareslija"'
Autor:
Nicola Cosgrove, Damir Varešlija, Stephen Keelan, Ashuvinee Elangovan, Jennifer M. Atkinson, Sinéad Cocchiglia, Fiona T. Bane, Vikrant Singh, Simon Furney, Chunling Hu, Jodi M. Carter, Steven N. Hart, Siddhartha Yadav, Matthew P. Goetz, Arnold D. K. Hill, Steffi Oesterreich, Adrian V. Lee, Fergus J. Couch, Leonie S. Young
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The molecular landscape of breast cancer brain metastases (BCBM) is still understudied, especially for different breast cancer subtypes. Here, the authors characterise subtype-specific BCBMs using genomics and transcriptomics and identify homologous
Externí odkaz:
https://doaj.org/article/55e3acfd61844f0f8a60e2f4411af4cc
Autor:
Lucía Zhu, Diana Retana, Pedro García‐Gómez, Laura Álvaro‐Espinosa, Neibla Priego, Mariam Masmudi‐Martín, Natalia Yebra, Lauritz Miarka, Elena Hernández‐Encinas, Carmen Blanco‐Aparicio, Sonia Martínez, Cecilia Sobrino, Nuria Ajenjo, Maria‐Jesus Artiga, Eva Ortega‐Paino, Raúl Torres‐Ruiz, Sandra Rodríguez‐Perales, RENACER, Riccardo Soffietti, Luca Bertero, Paola Cassoni, Tobias Weiss, Javier Muñoz, Juan Manuel Sepúlveda, Pedro González‐León, Luis Jiménez‐Roldán, Luis Miguel Moreno, Olga Esteban, Ángel Pérez‐Núñez, Aurelio Hernández‐Laín, Oscar Toldos, Yolanda Ruano, Lucía Alcázar, Guillermo Blasco, José Fernández‐Alén, Eduardo Caleiras, Miguel Lafarga, Diego Megías, Osvaldo Graña‐Castro, Carolina Nör, Michael D Taylor, Leonie S Young, Damir Varešlija, Nicola Cosgrove, Fergus J Couch, Lorena Cussó, Manuel Desco, Silvana Mouron, Miguel Quintela‐Fandino, Michael Weller, Joaquín Pastor, Manuel Valiente
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 3, Pp n/a-n/a (2022)
Abstract We report a medium‐throughput drug‐screening platform (METPlatform) based on organotypic cultures that allows to evaluate inhibitors against metastases growing in situ. By applying this approach to the unmet clinical need of brain metast
Externí odkaz:
https://doaj.org/article/192ccb44b2e3449a849f6353de0e50dd
Autor:
Stefan Prekovic, Theofilos Chalkiadakis, Merel Roest, Daniel Roden, Catrin Lutz, Karianne Schuurman, Mark Opdam, Liesbeth Hoekman, Nina Abbott, Tanja Tesselaar, Maliha Wajahat, Amy R Dwyer, Isabel Mayayo‐Peralta, Gabriela Gomez, Maarten Altelaar, Roderick Beijersbergen, Balázs Győrffy, Leonie Young, Sabine Linn, Jos Jonkers, Wayne Tilley, Theresa Hickey, Damir Vareslija, Alexander Swarbrick, Wilbert Zwart
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp n/a-n/a (2023)
Abstract Glucocorticoid receptor (GR) is a transcription factor that plays a crucial role in cancer biology. In this study, we utilized an in silico‐designed GR activity signature to demonstrate that GR relates to the proliferative capacity of nume
Externí odkaz:
https://doaj.org/article/7f89e9b972df425581429cdb0b5d1a09
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 2, Pp n/a-n/a (2022)
Abstract Obesity is highly prevalent in breast cancer patients and is associated with increased recurrence and breast cancer‐specific mortality. Glucocorticoids (GC) are used as an adjuvant in cancer treatment and are associated with promoting brea
Externí odkaz:
https://doaj.org/article/1b53f09e007443ac86f70ec0a068c9c2
Autor:
Leonie S. Young, Marie McIlroy, Arnold D.K. Hill, Peadar Ó Gaora, Yuan Hao, Ronán M. Conroy, Christopher Byrne, Paul Tibbitts, Fiona Bane, Jean McBryan, Damir Vareslija, Jane O'Hara
PDF file, 320KB, Supplementary Figures 1-9 Supplementary Figure 1: Expression levels of aromatase in our cell lines and aromatase activity assay Supplementary Figure 2: Proliferation of Aro and LetR in response to treatment Supplementary Figure 3: Ka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ae4d019c3ddc9c528331d39098517c
https://doi.org/10.1158/1078-0432.22452516.v1
https://doi.org/10.1158/1078-0432.22452516.v1
Autor:
Leonie S. Young, Marie McIlroy, Arnold D.K. Hill, Peadar Ó Gaora, Yuan Hao, Ronán M. Conroy, Christopher Byrne, Paul Tibbitts, Fiona Bane, Jean McBryan, Damir Vareslija, Jane O'Hara
PDF file, 14KB, Supplementary Table 1: Demographics of patients according to AIB1 status.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7033b85867a5983bc5a3b37415f247e4
https://doi.org/10.1158/1078-0432.22452513
https://doi.org/10.1158/1078-0432.22452513
Autor:
Leonie S. Young, Marie McIlroy, Arnold D.K. Hill, Peadar Ó Gaora, Yuan Hao, Ronán M. Conroy, Christopher Byrne, Paul Tibbitts, Fiona Bane, Jean McBryan, Damir Vareslija, Jane O'Hara
Purpose: The use of aromatase inhibitors (AI) in the treatment of estrogen receptor (ER)-positive, postmenopausal breast cancer has proven efficacy. However, inappropriate activation of ER target genes has been implicated in the development of resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc4eab5b7dbbf42587e7338f1c78b3d
https://doi.org/10.1158/1078-0432.c.6522498.v1
https://doi.org/10.1158/1078-0432.c.6522498.v1
Autor:
Leonie S. Young, Marie McIlroy, Arnold D.K. Hill, Peadar Ó Gaora, Yuan Hao, Ronán M. Conroy, Christopher Byrne, Paul Tibbitts, Fiona Bane, Jean McBryan, Damir Vareslija, Jane O'Hara
PDF file, 55KB, Supplementary table 2: Rate of incidence of disease recurrence according to AIB1, HER2, tumour grade, tumour size and nodal status in breast cancer patients treated with first-line AI.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2fa66a0f00b5924029d167bd089e3b
https://doi.org/10.1158/1078-0432.22452510
https://doi.org/10.1158/1078-0432.22452510
Autor:
Leonie S. Young, Marie McIlroy, Arnold D.K. Hill, Peadar Ó Gaora, Yuan Hao, Ronán M. Conroy, Christopher Byrne, Paul Tibbitts, Fiona Bane, Jean McBryan, Damir Vareslija, Jane O'Hara
PDF file, 213KB, Supplementary Table 3b ER/AIB1 overlap genelist - partial ERE.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b8193096e5cd1f7178710d25cda900
https://doi.org/10.1158/1078-0432.22452504.v1
https://doi.org/10.1158/1078-0432.22452504.v1
Publikováno v:
Pharmacology researchperspectives. 10(2)
Obesity is highly prevalent in breast cancer patients and is associated with increased recurrence and breast cancer-specific mortality. Glucocorticoids (GC) are used as an adjuvant in cancer treatment and are associated with promoting breast cancer m