Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Damir Simic"'
Autor:
Nancy Chen, David E. Ehmann, Robert Crooker, Katayoun Derakhchan, Xiaodong Fang, Brian Felice, Elizabeth J. Galbreath, Charles Glaus, Hongbo Gu, Yan Huang, Christine Li, Xing Li, Nan Liu, Kathleen Palmieri, Damir Simic, Joseph Sypek, Susan Thompson, Christopher T. Winkelmann, Vivian W. Choi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 286-302 (2023)
Mucopolysaccharidosis II (MPS II) is a rare lysosomal storage disease characterized by deficient activity of iduronate-2-sulfatase (I2S), leading to pathological accumulation of glycosaminoglycans (GAGs) in tissues. We used iduronate-2-sulfatase knoc
Externí odkaz:
https://doaj.org/article/b33a6cf79e06450e92ea9144dc1312b7
Autor:
Nianli Sang, Damir Simic
Publikováno v:
Experimental Hematology. 72:36-46
Histone deacetylase inhibitors (HDACi) have demonstrated effectiveness against lymphomas and myelomas in clinical practice. However, common to all currently approved broad acting HDACi (panHDACi) is dose limiting thrombocytopenia, which has prevented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb0dd15d42f96d765248b2dadd876fa
https://doi.org/10.1016/j.exphem.2018.12.007
https://doi.org/10.1016/j.exphem.2018.12.007
Autor:
Geraldine A. Hamilton, Katia Karalis, Jacob P. Fraser, Monicah A. Otieno, Riccardo Barrile, Fang Teng, Mimi Zhou, Donald E. Ingber, Andries D. van der Meer, Justin Nguyen, David Conegliano, Hyoungshin Park, Damir Simic, Abhishek Jain
Publikováno v:
Clinical pharmacology & therapeutics, 104(6), 1240-1248. Wiley-Blackwell
Clinical development of Hu5c8, a monoclonal antibody against CD40L intended for treatment of autoimmune disorders, was terminated due to unexpected thrombotic complications. These life-threatening side effects were not discovered during preclinical t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae54f10c9f3efaaf70dbe17018e47b84
https://doi.org/10.1002/cpt.1054
https://doi.org/10.1002/cpt.1054
Autor:
Hollie Skaggs, Heng-Keang Lim, Damir Simic, Alessandro Pocai, Wing W. Lam, Mark R. Player, Rhys Salter, Bhanu Singh, Monicah A. Otieno, Jan Snoeys, Avi Ghosh
Publikováno v:
Toxicological Sciences. 163:374-384
TAK-875, a GPR40 agonist, was withdrawn from Phase III clinical trials due to drug-induced liver injury (DILI). Mechanistic studies were conducted to identify potential DILI hazards (covalent binding burden (CVB), hepatic transporter inhibition, mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c8dabc0d28e07f9ae32807bc3b23e3
https://doi.org/10.1093/toxsci/kfx040
https://doi.org/10.1093/toxsci/kfx040
Autor:
Erio Barale, Katia Karalis, Riccardo Barrile, Kyung-Jin Jang, Monica Singer, Abhishek Srivastava, Anna Herland, Josiah Sliz, Barry Jones, Hyoungshin Park, Janna Nawroth, Geraldine A. Hamilton, Dominic P. Williams, Wing W. Lam, Gauri Kulkarni, Jonathan E. Rubins, Suzzette Haney, Linda C. Andersson, Manisha Sonee, Konstantia Kodella, Debora B. Petropolis, Monicah A. Otieno, Heng-Keang Lim, Lorna Ewart, Bhanu Singh, Carl L. Manthey, Janey Ronxhi, Donald E. Ingber, David Conegliano, Anthony J. Streeter, Damir Simic
Nonclinical rodent and non-rodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans contributing to drug failures in the clinic. Here we applied microengineere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77153c2fec6be0820279936c4ea70992
Autor:
Amy E. Chadwick, Oisin Douglas, Dominic P. Williams, B. Kevin Park, Damir Simic, Carol E. Jolly, Laleh Kamalian, Mario Monshouwer, Jan Snoeys
Publikováno v:
Current protocols in toxicology
Using galactose instead of glucose in the culture medium of hepatoma cell lines, such as HepG2 cells, has been utilized for a decade to unmask the mitochondrial liability of chemical compounds. A modified glucose-galactose assay on HepG2 cells, reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f063e1eeaf43c7963149955df9892dd4
https://doi.org/10.1002/cptx.76
https://doi.org/10.1002/cptx.76
Autor:
Bhanu Singh, Suzzette Haney, Carl L. Manthey, Riccardo Barrile, Anna Herland, Dominic P. Williams, Manisha Sonee, Katia Karalis, Monica Singer, David Conegliano, Heng-Keang Lim, Geraldine A. Hamilton, Donald E. Ingber, Monicah A. Otieno, Anthony J. Streeter, Lorna Ewart, Erio Barale, Linda C. Andersson, Barry Jones, Wing W. Lam, Damir Simic, Konstantia Kodella, Debora B. Petropolis, Josiah Sliz, Janey Ronxhi, Janna Nawroth, Abhishek Srivastava, Kyung-Jin Jang, Gauri Kulkarni, Hyoungshin Park, Jonathan E. Rubins
Publikováno v:
Science translational medicine. 11(517)
Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans, contributing to drug failures in the clinic. Here, we applied microengineer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e12fac7c745aecb2cdd286e4f142c77
https://pubmed.ncbi.nlm.nih.gov/31776474
https://pubmed.ncbi.nlm.nih.gov/31776474
Autor:
Jan Snoeys, Laleh Kamalian, B. Kevin Park, Dominic P. Williams, Amy E. Chadwick, Carol E. Jolly, Damir Simic, Mario Monshouwer, Oisin Douglas
Publikováno v:
TOXICOLOGY IN VITRO
The importance of mitochondrial toxicity in drug-induced liver injury is well established. The bioenergetic phenotype of the HepaRG cell line was defined in order to assess their suitability as a model of mitochondrial hepatotoxicity. Bioenergetic ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c30df695ad74462d47bc4f79e7ec50
http://livrepository.liverpool.ac.uk/3025983/1/Resubmission_HepaRG_Final.docx
http://livrepository.liverpool.ac.uk/3025983/1/Resubmission_HepaRG_Final.docx
Autor:
Marc H. Davies, Megan Fuller, Jamie J. Arnold, Craig E. Cameron, Terry Van Vleet, Michael J. Graziano, Thomas P. Sanderson, Damir Simic, Chris Storck, Catherine Euler, Oliver P. Flint, Bethany R. Baumgart, Suresh D. Sharma, Faye Wang, Roderick T. Bunch, Jae Kwagh
Publikováno v:
Toxicological Sciences
BMS-986094, the prodrug of a guanosine nucleotide analogue (2'-C-methylguanosine), was withdrawn from clinical trials due to serious safety issues. Nonclinical investigative studies were conducted as a follow up to evaluate the potential for BMS-9860
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83bd630158a6ca1a75515f89888cc40
https://doi.org/10.1093/toxsci/kfw135
https://doi.org/10.1093/toxsci/kfw135
Autor:
Carol E. Jolly, Rosalind E. Jenkins, B. Kevin Park, Alison J. Beckett, Jan Snoeys, Amy E. Chadwick, Sophie L. Penman, Oisin Douglas, Laleh Kamalian, Mario Monshouwer, Dominic P. Williams, Damir Simic
Publikováno v:
Toxicology and Applied Pharmacology
During its clinical development fialuridine caused liver toxicity and the death of five patients. This case remains relevant due to the continued development of mechanistically-related compounds against a back-drop of simple in vitro models which rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc33f6f2025f2dc67b6c695ac4dfd787
https://doi.org/10.1016/j.taap.2020.115163
https://doi.org/10.1016/j.taap.2020.115163