Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat

Autor: Damir Omerbašić, Ewan St. J. Smith, Mirko Moroni, Johanna Homfeld, Ole Eigenbrod, Nigel C. Bennett, Jane Reznick, Chris G. Faulkes, Matthias Selbach, Gary R. Lewin

Publikováno v: Cell Reports, Vol 17, Iss 3, Pp 748-758 (2016)

The naked mole-rat is a subterranean rodent lacking several pain behaviors found in humans, rats, and mice. For example, nerve growth factor (NGF), an important mediator of pain sensitization, fails to produce thermal hyperalgesia in naked mole-rats.

Externí odkaz: https://doaj.org/article/5a53381f1a6e4a2e9ea0fc3b22fdab77

Water-induced finger wrinkles do not affect touch acuity or dexterity in handling wet objects.

Autor: Julia Haseleu, Damir Omerbašić, Henning Frenzel, Manfred Gross, Gary R Lewin

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e84949 (2014)

Human non-hairy (glabrous) skin of the fingers, palms and soles wrinkles after prolonged exposure to water. Wrinkling is a sympathetic nervous system-dependent process but little is known about the physiology and potential functions of water-induced

Externí odkaz: https://doaj.org/article/e373ba2ae16e40ae922fbbb4e3e9f98c

Lipidome determinants of maximal lifespan in mammals

Autor: Gary R. Lewin, Lothar Willmitzer, Nigel C. Bennett, Julia Marchal, Florian Schroeder, Zhen Liu, Fanelie Wanert, Andrei Seluanov, Vera Gorbunova, Damir Omerbašić, Jane Reznick, Philipp Khaitovich, Jorge Azpurua, Svante Pääbo, Fabien Pifferi, Patrick Giavalisco, Pierrick Regnard, Katarzyna Bozek, Peng Shi, Ekaterina Khrameeva, Fabienne Aujard

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-00037-7⟩
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-00037-7⟩

Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18259508f01876a04139351f91aaf53c
https://doaj.org/article/1d2f7257382a4f6e9f237b66319e72e4

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

Autor: Ole Eigenbrod, Wiebke Hamann, Richard D. Minshall, Tetiana Kosten, Christin Zasada, Victoria M Gavaghan, Michael Gotthardt, Stefan Kempa, Gary R. Lewin, Bethany L. Peterson, John Larson, Heike Lutermann, Nigel C. Bennett, P. Henning J. L. Kuich, Vince G. Amoroso, Thomas J. Park, Ewan St. John Smith, Daniel T. Applegate, Brigitte M. Browe, Michael H. Radke, Vidya Govind, Jane Reznick, Gregory R.C. Blass, Damir Omerbašić, Valérie Bégay

Safe anaerobic metabolism Naked mole-rats live in large colonies deep underground in hypoxic conditions. Park et al. found that these animals fuel anaerobic glycolysis with fructose by a rewired pathway that avoids tissue damage (see the Perspective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620802a7ea88d559542ab6f073fb6b24
https://www.repository.cam.ac.uk/handle/1810/264126

A stomatin dimer modulates the activity of acid-sensing ion channels

Autor: Liudmila Lapatsina, Ewan St. John Smith, Joachim Behlke, Alexey Kozlenkov, Oliver Daumke, Kate Poole, David Schwefel, Janko Brand, Gary R. Lewin, Damir Omerbašić

Publikováno v: The EMBO Journal. 31:3635-3646

Stomatin proteins oligomerize at membranes and have been implicated in ion channel regulation and membrane trafficking. To obtain mechanistic insights into their function, we determined three crystal structures of the conserved stomatin domain of mou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::968ac16108231784ea33b1bc9965f129
https://doi.org/10.1038/emboj.2012.203